Test Price
2,800 AED✅ Home Collection Available
CRB2 Gene Focal Segmental Glomerulosclerosis Type 9 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CRB2 للكشف عن التصلب الكبيبي القطعي البؤري من النوع 9 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via Next‑Generation Sequencing (NGS) processed in our ISO‑accredited genomics laboratory. Every run includes Sanger confirmation of pathogenic variants.
Premium Logistics: Paid hospital‑grade home collection available 8 AM‑11 PM. Strict ISO‑certified cold‑chain transport for whole blood, extracted DNA, or FTA card samples. VIP mobile phlebotomy ensures minimal discomfort.
Clinical Guidance: Telephonic post‑test clinical interpretation session with a DHA‑licensed genetic counsellor included. You receive actionable insights on treatment implications and cascade screening.
Insurance & Payment: Direct billing verification via WhatsApp (+971 54 548 8731). We handle pre‑approvals with all UAE insurers.
الملخص التنفيذي: يقدم اختبار الجين CRB2 باستخدام تقنية التسلسل الجيني من الجيل التالي (NGS) تشخيصًا دقيقًا للتصلب الكبيبي القطعي البؤري من النوع 9. نضمن حساسية تشخيصية تصل إلى 99.9% من خلال مختبر معتمد دوليًا (ISO 9001:2015). يتوفر جمع العينات في المنزل عبر خدمة تبريد معتمدة، مع جلسة إرشاد جيني هاتفية بعد الاختبار لترجمة النتائج إلى خطة رعاية شخصية. التحقق من التأمين متاح عبر واتساب.
Comprehensive CRB2 Gene Analysis for Hereditary Nephrotic Syndrome
This single‑gene next‑generation sequencing test screens the entire coding region of CRB2—the gene responsible for focal segmental glomerulosclerosis type 9 (FSGS 9). Inherited in an autosomal recessive pattern, pathogenic variants lead to steroid‑resistant nephrotic syndrome, often progressing to end‑stage renal disease in childhood or early adulthood. In the UAE, where consanguinity rates may elevate recessive disease burden, this test provides families and clinicians with definitive molecular confirmation, enabling precise prognosis, tailored immunosuppressive strategies, and informed family planning.
يُعد هذا التحليل الجيني المتقدم الخيار الأكثر تخصيصًا لتأكيد تشخيص التصلب الكبيبي القطعي البؤري الوراثي في الإمارات، ويوفر معلومات أساسية لدعم إدارة المرض على المدى الطويل.
| Feature | Our Test (CRB2 NGS) | Conventional Sanger Sequencing |
|---|---|---|
| Methodology | NGS (Next‑Generation Sequencing) with Sanger validation | Sanger sequencing of individual exons |
| Turnaround Time | 3–4 weeks | 6–8 weeks for full gene |
| Coverage | Complete coding region ± flanking splice sites – detects SNVs, indels, and CNVs | Targeted exon analysis only; large deletions/duplications often missed |
| Clinical Utility | Confirms FSGS 9 diagnosis, guides family screening, and informs transplant eligibility | Partial gene sequencing; less informative for recessive inheritance patterns |
| Price (AED) | 2800 | Variable |
Physician Insight & Safety – Dr. Prabhakar Reddy, DHA 61713011
“A positive CRB2 result must be interpreted in the full clinical context; isolated genetic data does not dictate therapy. However, it empowers your nephrologist to refine immunosuppressive regimens, accelerates transplant readiness, and enables cascade testing of at‑risk siblings. As a clinical geneticist, I always emphasize that this test is a starting point for a lifelong, family‑centered care plan.”
⚠️ Medication & Safety Warning
Do not discontinue or modify any prescribed medication (e.g., steroids, immunosuppressants, antihypertensives) based solely on this genetic result. Always consult your treating physician.
- Exclusion criteria: Inability to provide an adequate biological sample (blood, DNA, or FTA card); suspected acute kidney injury requiring urgent intervention.
- ER red flags: Rapidly progressing edema, oliguria/anuria, uncontrolled hypertension, or sudden drop in urine output demand immediate emergency care – do not wait for genetic results.
- Pre‑test requirement: A detailed clinical history and a three‑generation pedigree chart, preferably drawn with a genetic counsellor, must accompany the sample to maximize interpretive accuracy.
Patient FAQ – Bilingual Clinical Guidance
1. What is the CRB2 gene test and why is it ordered?
Snippet: The CRB2 NGS test identifies disease‑causing variants in the CRB2 gene that lead to steroid‑resistant nephrotic syndrome (FSGS type 9), enabling definitive diagnosis and targeted family screening.
يكتشف اختبار CRB2 NGS الطفرات المسببة للمرض في جين CRB2، مما يؤكد تشخيص التصلب الكبيبي القطعي البؤري من النوع 9 الذي لا يستجيب للستيرويدات، ويساعد في فحص أفراد الأسرة المعرضين للخطر.
2. How is the sample collected and can it be done at home?
Snippet: A small volume of whole blood, extracted DNA, or a finger‑prick blood spot on an FTA card is collected; we offer ISO‑certified cold‑chain home phlebotomy across all Emirates.
تُؤخَذ عينة صغيرة من الدم الوريدي أو نقطة دم على بطاقة FTA، وتتوفر خدمة السحب المنزلي المعتمدة بنظام التبريد في جميع الإمارات.
3. What will the results tell my doctor and what happens next?
Snippet: Results classify variants as pathogenic, likely pathogenic, or variants of uncertain significance, guiding kidney biopsy interpretation, transplant evaluation, and carrier testing for relatives.
تصنف النتائج الطفرات إلى ممرضة أو محتملة المرضية، مما يساعد في تفسير خزعة الكلى وتقييم الزراعة وفحص الأقارب لحمل الجين.
📋 Direct Insurance Billing
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This is performed under UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) and complies with the UAE Child Data Protection Law 2026 (CDS) for minors and the UAE PDPL. All genetic data is de‑identified and stored in encrypted, DHA‑approved servers. Laboratory accredited to ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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