Test Price
2,800 AED✅ Home Collection Available
COQ4 Gene Sequencing NGS Test for Coenzyme Q10 Deficiency Type 7 in UAE | 2,800 AED
Executive Summary & Core Metrics
Service Benchmarks
- Diagnostic Sensitivity: 99.9% via ISO 9001:2015 Accredited Next-Generation Sequencing (Cert: INT/EGQ/2509DA/3139).
- Sample Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM).
- Post-Test Support: Telephonic Clinical Guidance provided by a Consultant Medical Genetics upon result delivery.
- Insurance & Billing: Direct Billing Verification and Insurance Coverage Checks via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The COQ4 Gene Sequencing Test utilizes clinical-grade Next-Generation Sequencing (NGS) to analyze the complete coding region and exon-intron boundaries of the COQ4 gene. This advanced molecular assay is the definitive diagnostic standard for Coenzyme Q10 Deficiency Type 7, a rare autosomal recessive mitochondrial disorder. Accurate molecular confirmation is critical for initiating high-dose CoQ10 supplementation, which can significantly improve neurological and renal outcomes. This test is recommended for individuals presenting with unexplained steroid-resistant nephrotic syndrome, Leigh syndrome, or a family history of primary CoQ10 deficiency.
| Feature | DNA Labs UAE COQ4 NGS Test | Standard Targeted Variant Analysis |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) – Full gene coverage | PCR-based genotyping for known familial mutations |
| Diagnostic Yield | 99.9% (detects novel, missense, and splice-site variants) | ~85% (misses de-novo or private mutations) |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Price (AED) | 2,800 AED | ~2,000 AED |
| Clinical Utility | Confirms diagnosis, guides CoQ10 dosing, enables cascade family screening | Limited to previously identified familial mutations only |
Physician Insight & Safety Protocols
"Definitive molecular confirmation of primary CoQ10 deficiency through comprehensive NGS sequencing is a pivotal step in pediatric and adult mitochondrial diagnostics. Identifying pathogenic variants in COQ4 empowers clinicians to initiate high-dose CoQ10 therapy with confidence, potentially stabilizing or improving renal and neurological function. All results must be correlated with clinical presentation and biochemical profiles in the context of a multidisciplinary metabolic team."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory & Medication Safety
- Prescribed Therapy: Do not discontinue, initiate, or modify any prescribed medication or CoQ10 supplementation without consulting your supervising specialist.
- Diagnostic Context: A negative result on this panel does not rule out other mitochondrial or metabolic disorders. Further biochemical and genetic workup may be indicated based on clinical judgement.
Emergency Red Flags & Exclusion Criteria
- Exclusion Criteria: This test is not intended for asymptomatic individuals without a clinical indication or confirmed family history. It is not a standalone screening tool for general wellness.
- Emergency Symptoms: Seek immediate emergency medical attention if the patient experiences new-onset seizures, acute vision loss, profound muscle weakness, or signs of acute kidney injury (oliguria, hematuria). These symptoms may indicate rapid disease progression requiring urgent intervention.
Patient FAQ & Clinical Guidance
1. What is the purpose of the COQ4 gene NGS test?
This test identifies pathogenic mutations in the COQ4 gene to confirm a diagnosis of Coenzyme Q10 Deficiency Type 7. An accurate molecular diagnosis allows for targeted treatment with oral CoQ10 supplementation, which can be lifesaving and is essential for guiding family planning and genetic counseling.
2. How is the sample collected for this test?
A standard peripheral whole blood sample (or a dried blood spot on an FTA card) is collected by our DHA-licensed phlebotomy team during a scheduled home visit. The sample is transported to our CAP-accredited laboratory under ISO-certified temperature-controlled cold-chain conditions to ensure DNA integrity.
3. How long does it take to receive the results?
The complete sequencing, bioinformatics analysis, and clinical interpretation cycle requires a standard turnaround time of 3 to 4 weeks. Once finalized, a Consultant Medical Genetics will provide a telephonic consultation to explain the report and discuss recommended clinical management steps.
UAE Regulatory & Data Privacy Adherence
Your Data. Your Rights. Our Compliance.
This genetic testing service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical safety, patient consent, and medical liability protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is processed with the highest level of confidentiality and security within our ISO 9001:2015 certified infrastructure (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | COQ4 Gene Sequencing (NGS) – Coenzyme Q10 Deficiency Type 7 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS), Complete Coding Region & Splice Sites |
| ICD-10-CM Code | E88.49 (Other mitochondrial disorders), N04.9 (Nephrotic syndrome, unspecified) |
| LOINC Code | 81247-9 (DNA sequencing of gene for mutation) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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