Test Price
2,800 AED✅ Home Collection Available
COL2A1 Gene Legg-Calve-Perthes Disease Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Diagnostic Sensitivity: 99.9%
ISO-accredited NGS processing with full gene coverage of the COL2A1 coding region.
Premium Logistics
VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all UAE emirates.
Clinical Guidance
Post-test telephonic result interpretation by DHA-licensed genetic counsellors and consultant medical geneticist.
Insurance
Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test analyses the entire coding region of the COL2A1 gene to detect pathogenic variants causing Legg-Calve-Perthes disease, a childhood hip disorder characterised by avascular necrosis of the femoral head. The assay is performed on an Illumina platform in an ISO-accredited laboratory with DHA-compliant reporting, delivering full gene coverage and >99.9% analytical sensitivity for point mutations and small insertions or deletions.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Full gene coverage, >99.9% analytical sensitivity | Limited to known hotspots; may miss rare variants |
| Methodology | Next-Generation Sequencing (Illumina platform) | Capillary electrophoresis (Sanger) |
| Turnaround Time | 3-4 weeks | 6-8 weeks |
Physician Insight & Safety Protocols
"A positive COL2A1 result provides strong molecular evidence supporting a diagnosis of Legg-Calve-Perthes disease, yet clinical correlation with hip imaging and orthopaedic assessment remains essential. I advise every family to review the genetic findings together with a paediatric orthopaedic specialist before initiating any treatment pathway." — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
⚠️ Important Medication Notice
Do not discontinue any prescribed medication or supplement without explicit consultation with your treating physician. This genetic test does not replace ongoing clinical management or orthopaedic supervision.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Children under 13 years without legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Active systemic infection or severe coagulopathy precluding a safe blood draw.
Emergency Red Flags
- Sudden inability to bear weight on the affected limb.
- Severe hip pain accompanied by fever.
- Signs suggestive of avascular crisis or acute joint effusion — seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of the COL2A1 NGS test for Legg-Calve-Perthes disease?
This test provides 99.9% analytical sensitivity for detecting point mutations and small insertions or deletions in the COL2A1 gene, confirming a genetic predisposition in over 90% of isolated familial cases of Legg-Calve-Perthes disease.
2. Is home blood collection available across all UAE emirates for this test?
Yes, our DHA-licensed mobile phlebotomy team covers Dubai, Abu Dhabi, Sharjah, Ajman, Ras Al Khaimah, Fujairah, and Umm Al Quwain. All samples are transported under temperature-controlled cold-chain conditions to preserve nucleic acid integrity.
3. How should I prepare my child for the COL2A1 genetic test?
No fasting is required. A simple venipuncture blood draw or a painless finger-prick FTA card can be used. A pre-test genetic counselling session to document family history and obtain informed consent is mandatory before specimen collection.
4. What is the turnaround time for receiving results?
Results are typically available within 3 to 4 weeks from sample receipt. A detailed molecular report including variant classification per ACMG guidelines will be provided along with a telephonic consultation for interpretation.
UAE Regulatory & Data Privacy Adherence
🔒 Data Privacy & Compliance Framework
All genetic data generated by this test is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your results are encrypted, access-controlled, and never shared with third parties without your explicit written authorisation.
Clinical & Logistical Metadata
| Test Name | COL2A1 Gene Legg-Calve-Perthes Disease Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Peripheral whole blood |
| Methodology Used | Next-Generation Sequencing (NGS) — Illumina platform |
| ICD-10-CM Code | M91.1 |
| LOINC Code | 54047-4 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians