Test Price
2,800 AED✅ Home Collection Available
COA5 Gene Genetic Test for Fatal Infantile Cardioencephalomyopathy (COX Deficiency Type 3) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين COA5 بتقنية التسلسل الجيني (NGS) للاعتلال القلبي الدماغي القاتل الرضيعي (عوز السيتوكروم سي أكسيداز النوع الثالث) في الإمارات | 2800 درهم | إرشادات هيئة الصحة بدبي 2026
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited Next Generation Sequencing with Sanger confirmation.
Premium Logistics: Hospital-Grade Home Collection (8 AM – 11 PM) using ISO-certified cold-chain transport and VIP Pediatric Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Genetic Counseling by DHA-licensed specialists to interpret results and plan next steps.
Insurance Direct Billing: Verify coverage via WhatsApp at +971 54 548 8731.
ضمان الدقة التشخيصية بنسبة 99.9% عبر معالجة معتمدة من الأيزو 9001:2015، مع جلسة استشارة وراثية إلزامية قبل الفحص وفقاً لقانون دولة الإمارات.
Clinical Test Overview
The COA5 Genetic Test definitively diagnoses fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency type 3, a severe mitochondrial disorder presenting in early infancy with encephalopathy, cardiomyopathy, and metabolic crisis. يكشف هذا التحليل الطفرات في جين COA5 لتأكيد التشخيص الدقيق وتوجيه الاستشارة الوراثية للعائلات المعرضة للخطر.
| Feature | Our Test (NGS + Sanger) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity; full gene coverage incl. deep intronic variants | ∼95% sensitivity; may miss large deletions/duplications |
| Methodology | Next Generation Sequencing (NGS) with orthogonal Sanger confirmation | Conventional Sanger sequencing only |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
Physician Insight & Clinical Safety Protocol
Dr. PRABHAKAR REDDY, DHA License 61713011, Consultant Cardiologist, shares: “This NGS test is a cornerstone in confirming fatal infantile COX deficiency due to COA5 mutations. A positive result must be correlated with the infant’s clinical picture and family history—it is not a stand-alone diagnosis. I urge families to seek comprehensive genetic counselling before testing.”
⚠ Medication Warning: Do not discontinue prescribed cardiac or metabolic medication without consulting your specialist. Abrupt withdrawal can precipitate a fatal arrhythmia or acute encephalopathy.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Infants with severe hemodynamic instability or acute metabolic decompensation requiring intensive care — do not delay emergency management for test collection; schedule venipuncture only when clinically stable.
- Emergency Red Flags: Seek immediate medical attention if the infant exhibits new‑onset respiratory distress, profound bradycardia (<60 bpm), status epilepticus, or sudden loss of consciousness. These are life‑threatening signs of the underlying disorder and are not manageable via teleconsultation alone.
This test requires a mandatory pre‑test genetic counselling session to draw a pedigree and obtain informed consent, as mandated by UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) and CDS Law 2026 for minors.
Patient FAQ & Clinical Guidance
1. What is the COA5 gene test for cardioencephalomyopathy?
This NGS-based genetic test analyzes the entire coding region of the COA5 gene to identify pathogenic mutations responsible for fatal infantile cytochrome c oxidase deficiency type 3.
يقوم فحص جين COA5 بتحليل الجين الكامل لتحديد الطفرات المسببة للاعتلال القلبي الدماغي القاتل الرضيعي من النوع الثالث لعوز السيتوكروم سي أكسيداز.
2. How is the sample collected and what is the turnaround time?
A certified pediatric phlebotomist collects a small venous blood sample or a single drop of blood on an FTA card at your home; results are delivered in 3 to 4 weeks.
يتم سحب عينة دم وريدي بسيطة أو قطرة دم على بطاقة FTA في المنزل بواسطة ممرض أطفال مرخص، ونتائج التحليل تصدر خلال 3 إلى 4 أسابيع.
3. Is genetic counseling included before the test?
Yes, a mandatory pre‑ genetic counselling session with a DHA-licensed counsellor is provided to explain inheritance, clinical implications, and to construct a three‑generation pedigree.
نعم، جلسة استشارة وراثية إلزامية قبل الفحص متوفرة مع مستشار وراثي مرخص من هيئة الصحة بدبي لشرح الوراثة ورسم شجرة العائلة.
UAE Regulatory Compliance: This service adheres to Federal Decree‑Law No. 41 of 2024 on Patient Rights, the 2026 Child Data Sovereignty (CDS) Law for genetic testing of minors, and the UAE PDPL for data privacy. Sample collection and processing are performed under ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139).
Laboratory License: 9834453. Contact: +971 54 548 8731 (8 AM – 11 PM).
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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