Test Price
2,800 AED✅ Home Collection Available
CLDN1 Gene (Ichthyosis, Leukocyte Vacuoles, Alopecia, Sclerosing Cholangitis) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Lab (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM, UAE-wide).
- Clinical Guidance: Complimentary telephonic post-test counseling with a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This CLDN1 gene sequencing test uses Next‑Generation Sequencing (NGS) to detect pathogenic variants in the CLDN1 gene, causing the rare syndrome of ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC). The analysis provides a definitive molecular diagnosis to guide dermatologic, hepatologic, and reproductive care under DHA‑accredited protocols.
| Feature | Our Test (NGS Full‑Gene) | Closest Alternative (Sanger Single‑Exon) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) | Sanger Sequencing (limited exon coverage) |
| Diagnostic Sensitivity | 99.9% | ~97% (misses deep‑intronic variants) |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Price (AED) | 2,800 | ~3,500 |
Physician Insight & Safety Protocols
“Dear Patient, as we analyze your genetic blueprint, we understand the emotional weight of linking seemingly separate symptoms—skin, hair, liver—into a unified diagnosis. This test alone doesn’t replace clinical judgment; always discuss results with your overseeing physician to determine the best care path.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA License: 9294403
Advisory
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Safety Check
- Exclusion Criteria: Not recommended for individuals who have received a bone marrow transplant within the last 6 weeks (donor DNA interference). Pregnant women may still proceed after consultation.
- Emergency Red Flags: If you experience acute jaundice, high fever with chills, or severe upper‑right abdominal pain, stop routine activities and go to the nearest emergency department – these may signal acute cholangitis requiring urgent intervention.
Patient FAQ & Clinical Guidance
1. What is the CLDN1 gene test used for in the UAE?
This NGS‑based test identifies pathogenic CLDN1 mutations to confirm ILVASC syndrome, enabling targeted dermatologic, hepatologic and reproductive care. The analysis provides a definitive molecular diagnosis for patients presenting with ichthyosis, alopecia, leukocyte vacuoles, or sclerosing cholangitis. It also informs familial variant screening and reproductive risk assessment under DHA‑accredited protocols.
2. How is the sample collected at home, and what is the turnaround time?
A DHA‑licensed phlebotomist performs a gentle venipuncture in your home, with results delivered within 3–4 weeks through ISO‑certified processing. You can choose a small whole blood draw, an FTA card finger‑prick, or submission of previously extracted DNA. Samples are transported under strict cold‑chain conditions from 8 AM to 11 PM. The 3–4 week TAT covers full NGS sequencing, bioinformatics analysis, and clinical interpretation.
3. What do positive or negative results mean for my health?
A positive result confirms CLDN1‑related syndrome, prompting proactive liver surveillance and dermatologic care; a negative result reduces but does not eliminate genetic risk. A pathogenic variant calls for lifelong monitoring of liver function and bile ducts, while a negative result may still require further testing if clinical suspicion remains. All interpretations must be coupled with genetic counseling and specialist follow‑up.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Privacy
This test is performed under the regulatory framework of the Dubai Health Authority (DHA) and complies with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – Ensuring confidentiality of genetic information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – Governing secure health data exchange.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – Upholding patient safety and clinical governance.
- ISO 9001:2015 Certification No.: INT/EGQ/2509DA/3139 – Quality management in laboratory processes.
DHA Facility License Number: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | CLDN1 Gene Sequencing (Ichthyosis, Leukocyte Vacuoles, Alopecia, Sclerosing Cholangitis) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood, FTA Card, or Extracted DNA (Peripheral Blood) |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | Q87.8 (Other specified congenital malformation syndromes) |
| LOINC Code | 48000-5 (Genetic testing by next generation sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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