Test Price
2,800 AEDโ Home Collection Available
CDK6 Gene Microcephaly, Autosomal Recessive Type 12 Genetic Test in UAE
Executive Summary & Core Metrics
Clinical Reliability & Compliance
The CDK6 Gene Microcephaly NGS Test at DNA Labs UAE delivers 99.9% diagnostic sensitivity through ISO 9001:2015 certified next-generation sequencing. This molecular diagnostic identifies pathogenic mutations in the CDK6 gene causing autosomal recessive primary microcephaly type 12, a severe neurodevelopmental disorder affecting cortical development.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic counselors.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CDK6 Gene Microcephaly NGS Test identifies pathogenic mutations in the CDK6 gene, which cause autosomal recessive primary microcephaly type 12, a severe neurodevelopmental disorder. This genetic analysis confirms clinical diagnosis, identifies carrier status, and enables informed family planning through comprehensive molecular diagnostics.
| Feature | Our CDK6 NGS Test at DNA Labs UAE | Standard PCR/Sanger Panel |
|---|---|---|
| Precision | Full gene coverage with 99.9% analytical sensitivity | Hotspot analysis only; risk of missing novel variants |
| Methodology | Illumina NovaSeq X Plus NGS, Sanger validation | Capillary Sanger sequencing of targeted exons |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Regulatory Standard | DHA Licensed, ISO 9001:2015 Certified | Variable laboratory certifications |
Physician Insight & Safety Protocols
โThe CDK6 gene plays a critical role in cell cycle regulation and centrosome duplication during neurogenesis. A comprehensive NGS-based analysis is essential because mutations in this gene produce variable expressivity ranging from isolated microcephaly to complex neurological presentations. I emphasize that a negative result does not exclude other genetic causes; therefore, a thorough clinical evaluation including detailed family pedigree analysis and neuroimaging correlation remains mandatory. All patients must discuss results with a pediatric neurologist and certified genetic counselor to integrate molecular findings with clinical phenotype.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Safety Considerations
Clinical Advisory Notice
This test provides definitive genetic confirmation for CDK6-related microcephaly. Patients must not discontinue prescribed medications without consulting their treating physician. All clinical decisions should be made in consultation with a qualified healthcare provider.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Active systemic infection or hemodynamic instability precluding safe venipuncture; inability to provide informed consent; testing of minors without legal guardian consent (per UAE federal regulations).
- Emergency Red Flags: New-onset seizures, acute loss of developmental milestones, signs of raised intracranial pressure (projectile vomiting, lethargy, bulging fontanelle), or sudden neurological regression. Seek immediate emergency medical attention.
- Data Privacy: All genetic data are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, stored exclusively on HIPAA-compliant servers within the UAE.
- Legal Mandate: Clinical testing safety and patient consent comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the CDK6 gene test used for?
Diagnostic Precision: This single-gene NGS test sequences the entire CDK6 coding region and splice sites to diagnose autosomal recessive primary microcephaly type 12, confirm carrier status, and guide family planning decisions. Results are interpreted alongside clinical phenotype by DHA-licensed genetic counselors.
2. What sample types are accepted, and how is collection arranged?
Convenience & Flexibility: We accept peripheral whole blood in EDTA tubes (3โ5 mL), extracted DNA (1 ยตg minimum), or dried blood spot on FTA cards. Our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service is available daily from 8 AM to 11 PM across all UAE emirates, ensuring specimen integrity during transport.
3. How should I prepare for the test, and is genetic counseling required?
Mandatory Pre-Test Counseling: A pre-test genetic counseling session is mandatory to draw a detailed three-generation family pedigree, discuss potential implications of positive, negative, and variant of uncertain significance results, and obtain written informed consent. No fasting is required unless combined with other bloodwork; patients should bring any prior medical records, neuroimaging reports, and family history documentation.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection Framework
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to the highest standards of genetic data protection and clinical governance. All molecular diagnostic services comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic data are encrypted, stored on UAE-based HIPAA-compliant servers, and accessible only to authorized clinical personnel. Patients retain full rights to access, rectify, and request deletion of their genetic data under PDPL Article 14.
Clinical & Logistical Metadata
| Test Name | CDK6 Gene Microcephaly, Autosomal Recessive Type 12 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or FTA Card Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq X Plus) with Sanger Confirmation |
| ICD-10-CM Code | Q02 (Microcephaly) |
| LOINC Code | 21636-5 (Genetic analysis CDK6 gene) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians