Test Price
2,800 AED✅ Home Collection Available
ATIC Gene AICA-Ribosiduria due to ATIC Deficiency Genetic Test
Executive Summary & Core Metrics
Guaranteed Diagnostic Precision with UAE-Compliant, E-E-A-T Driven Care
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Laboratory Operations.
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy, available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed physicians.
- ✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 (UAE Insurance Coverage Pre-approval).
- ✓ Turnaround Time: 3 to 4 Weeks from sample receipt to comprehensive final report with ACMG-classified variant interpretation.
Test Overview & Methodology
The ATIC Gene Genetic Test detects pathogenic variants in the ATIC gene causing AICA-ribosiduria, a severe autosomal recessive disorder of purine metabolism. This test screens the entire coding region via Next Generation Sequencing, providing definitive diagnosis and carrier status for affected families in the UAE. A mandatory genetic counselling session precedes sample collection to document a detailed pedigree chart of family members affected with AICA-ribosiduria due to ATIC deficiency. Patients should provide complete clinical history including previous biochemical testing, imaging, and current medication list. No special fasting is required. For patients with recent transfusion, notify our team to optimize sampling timing.
| Feature | Our ATIC NGS Test (UAE) | Conventional Single-Gene Sequencing |
|---|---|---|
| Precision | >99.9% analytical sensitivity with full exon coverage | ~95% due to limited read depth and incomplete regions |
| Methodology | Illumina NGS with Sanger confirmation for clinically significant variants | Capillary sequencing of selected exons, often missing deep intronic mutations |
| Turnaround Time | 3-4 Weeks including expert interpretation | 6-8 Weeks, slower due to fragmented workflow |
| Clinical Interpretability | DHA/MOHAP-standard nomenclature and ACMG-classified variant reporting | Often generic reports without correlation to UAE population databases |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant in Medical Genetics, I emphasize that a positive ATIC result is not a solitary diagnostic verdict but must be integrated into a thorough clinical and biochemical evaluation. This test is a powerful tool, yet it is the correlation with a patient's symptoms, family history and amino-imidazole carboxamide measurements that truly guides management. At our center, we ensure every result is discussed with the ordering physician and patient to chart a safe, personalised care pathway."
— Lina Osama Zaki Quteineh (DHA Registration ID: 9294403), Consultant Medical Genetics
Medication Advisory
⚠ Medication Warning
Do not discontinue any prescribed medication or supplement without consulting your doctor. Genetic test results may influence treatment strategies, but sudden cessation can be dangerous.
Exclusion Criteria & Emergency Red Flags
- Individuals unable to provide informed consent unless legally authorized representative available.
- Active severe infection or acute metabolic decompensation requiring immediate hospitalization — seek emergency care first.
- Recent blood transfusion less than 2 weeks may cause sample contamination; reschedule as advised.
- If the patient experiences seizures, severe vomiting, lethargy, or loss of consciousness, proceed to the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What does the ATIC NGS test detect and how long will I wait for results?
The test screens the entire coding sequence of the ATIC gene for disease-causing variants linked to AICA-ribosiduria, a rare metabolic disorder, providing near-definitive diagnosis within 3 to 4 weeks from sample receipt.
2. Can this test be used for a healthy individual wanting a genetic check before marriage in the UAE?
Yes, as a carrier screening test it aligns with the UAE's premarital genetic screening guidelines, helping couples understand the risk of having an affected child. The test is conducted under the oversight of DHA-licensed medical geneticists.
3. How does home collection work and what are the sample requirements?
A DHA-certified mobile phlebotomist arrives at your location within 8 AM to 11 PM, collects 2-3 mL of whole blood in an EDTA tube or one drop on an FTA card, and transports it in a temperature-controlled cold chain immediately to the laboratory.
4. What preparation is needed before sample collection?
A mandatory genetic counselling session is required to document a detailed pedigree chart. Provide complete clinical history including previous biochemical testing, imaging, and current medications. No fasting is required. If using an FTA card, ensure the blood drop is fully dried before packing.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
This test is performed in full compliance with UAE federal regulations governing genetic data and patient privacy. All personal health information is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). The use of information and communication technology in health fields adheres to Federal Law No. 2 of 2019. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
DNA Labs UAE is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143. All genetic results are reported using ACMG-classified variant nomenclature and are reviewed by DHA-licensed medical geneticists before release.
Clinical & Logistical Metadata
| Test Name | ATIC Gene AICA-Ribosiduria due to ATIC Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | E79.8 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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