Test Price
2,800 AEDโ Home Collection Available
APC2-Related Neurodevelopmental Disorder Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
This targeted genetic test uses next-generation sequencing to detect pathogenic variants in the APC2 gene, associated with a spectrum of neurodevelopmental delays and intellectual disability. The assay is performed in an ISO-accredited laboratory under stringent quality controls, ensuring diagnostic accuracy exceeding 99.9% for single nucleotide variants and small indels.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM โ 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counseling by a board-certified medical geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The APC2 genetic test employs targeted next-generation sequencing of the APC2 coding region and flanking intronic sequences. This method provides high-resolution detection of pathogenic single-nucleotide variants, small insertions/deletions, and splice-site alterations. Unlike whole-exome sequencing, which offers broader but shallower coverage, this targeted assay delivers deeper read depth for the APC2 gene, resulting in superior analytical sensitivity and specificity for variants in this clinically actionable region.
| Feature | APC2 Targeted NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity for APC2 SNVs/indels | ~95% for exome-wide variants |
| Method | Targeted Next Generation Sequencing (NGS) | Capture-based Whole Exome Sequencing |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Price (AED) | 2,800 | 4,500 โ 5,500 |
Physician Insight & Safety Protocols
โGenetic results carry profound implications for families. This targeted APC2 test offers high diagnostic certainty, but it must always be interpreted in the full clinical context of neurological examination, developmental history, and parental carrier studies. A negative result does not exclude other genetic or environmental causes. I recommend pre- and post-test genetic counseling to ensure informed decision-making.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication & Clinical Guidance
Do not discontinue or alter any prescribed medications, including antiepileptic or neurodevelopmental therapies, without direct consultation with your physician. This genetic test is a diagnostic tool and does not replace clinical monitoring or emergency care.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active infection, bleeding disorders, or inability to provide a blood/DNA sample safely; defer testing if acutely unwell.
- ER Red Flags: Severe neurodevelopmental regression, uncontrolled seizures, loss of consciousness, or any sudden neurological deterioration โ seek emergency medical care immediately.
- Minors: All testing on minors requires parental/guardian consent and mandatory pre-test genetic counseling, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the APC2 gene and why is it tested for neurodevelopmental disorders?
The APC2 gene provides instructions for a protein that regulates nerve cell growth, synaptic plasticity, and brain development. Pathogenic variants in APC2 disrupt these processes, leading to a range of neurodevelopmental delays, intellectual disability, and occasionally epilepsy. This test detects those variants to confirm diagnosis and enable targeted management.
2. How is the APC2 genetic test performed and what sample is required?
The test requires a simple peripheral blood draw (5 mL whole blood in an EDTA tube) or a dried blood spot on an FTA card. Our VIP mobile phlebotomy service collects samples at your home or office, maintaining cold-chain integrity. Extracted DNA is then analyzed by targeted next-generation sequencing, with results typically available within 3โ4 weeks.
3. How accurate is this APC2 test and can it rule out all neurodevelopmental disorders?
This targeted NGS assay achieves over 99.9% analytical sensitivity for single nucleotide variants and small deletions/insertions within the APC2 gene. However, a negative result does not exclude other genetic or non-genetic causes of neurodevelopmental conditions. This test is one important piece of the diagnostic puzzle and should be followed by comprehensive clinical evaluation.
UAE Regulatory & Data Privacy Adherence
This genetic test and all associated data handling comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring patient genetic data privacy and security.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing digital health data and telemedicine.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ protecting patient consent and safety in clinical testing.
- ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) โ global quality management standards for laboratory processes.
DHA Facility License Number: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | APC2-Related Neurodevelopmental Disorder Genetic Test (Targeted NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or Dried Blood Spot (FTA card) |
| Methodology Used | Targeted Next Generation Sequencing (NGS) |
| ICD-10-CM Code | F84.9 (Pervasive developmental disorder, unspecified) |
| LOINC Code | 74092-0 (Gene mutations found in sequence analysis by next generation sequencing) |
| DHA Facility License & Laboratory Address | License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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