Test Price
2,800 AED✅ Home Collection Available
AGT Gene Renal Tubular Dysgenesis (AGTRD) NGS Genetic Test in Dubai
Executive Summary & Core Metrics
DNA Labs UAE is the trusted provider for AGT gene sequencing in the GCC region.
This advanced Next-Generation Sequencing (NGS) assay targets the entire AGT gene to detect pathogenic variants responsible for autosomal recessive renal tubular dysgenesis, providing a definitive molecular diagnosis. The test delivers >99.9% analytical sensitivity and is processed in our CAP-accredited, ISO 9001:2015 certified laboratory. Logistics include VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM, and complimentary post-test genetic counseling by our specialist consultant.
Test Overview & Methodology
The AGT gene encodes angiotensinogen, a critical component of the renin-angiotensin system essential for fetal kidney development and blood pressure regulation. Pathogenic variants in AGT disrupt this pathway, leading to oligohydramnios sequence, pulmonary hypoplasia, and severe neonatal renal failure. This NGS test comprehensively covers all coding exons, intronic boundaries, and the promoter region to ensure high-fidelity variant detection.
| Feature | This Test (NGS) | Alternative (Sanger) |
|---|---|---|
| Genomic Coverage | Whole AGT gene (exons, introns, promoter) | Single exon or hotspot regions only |
| Sensitivity | >99.9% analytical sensitivity/specificity | ~98% for targeted regions |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (sequential reactions) |
Physician Insight & Safety Protocols
Insight from Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA License: 9294403
"Genetic testing for renal tubular dysgenesis requires more than just sequencing; it demands expert interpretation of the renin-angiotensin system biology. A precise molecular diagnosis informs recurrence risks and opens options for preimplantation genetic testing. I strongly advise that this test be conducted under the supervision of a clinical geneticist to ensure accurate variant classification and responsible counseling for the entire family."
Treatment Advisory & Clinical Safety
Important Advisory:
Do not discontinue or alter any prescribed medications, especially antihypertensive agents or nephrological therapies, without explicit instruction from your consulting specialist. This genetic test is a diagnostic and risk-assessment instrument and does not replace routine fetal surveillance, clinical monitoring, or ongoing medical management. Always consult your physician before making health decisions based on genetic results.
Exclusion Criteria & Emergency Red Flags
- Minors under 18 years of age must have explicit parental or guardian consent, in full compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Patients who are not currently under the care of a referring nephrologist or geneticist. A mandatory pre-test genetic counseling session is required to assess family pedigree.
- Active bleeding disorder or ongoing anticoagulant therapy without recent INR clearance from a physician.
- Acute febrile illness, symptomatic infection, or known COVID-19 positive status on the scheduled date of blood collection.
- If you experience acute chest pain, sudden severe dizziness, or difficulty breathing on the day of the draw, postpone all non-emergency procedures and seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What specific condition does the AGT NGS genetic test diagnose?
This test detects pathogenic mutations in the AGT gene responsible for autosomal recessive renal tubular dysgenesis, a severe congenital nephrological disorder. Confirming the molecular etiology allows physicians to provide accurate prognostic guidance and enables families to explore informed reproductive options, including preimplantation genetic diagnosis (PGD).
2. How is the sample collected, and is home phlebotomy available?
The test requires 3–5 mL of peripheral whole blood collected in a standard EDTA tube. DNA Labs UAE provides a premium VIP mobile phlebotomy service with temperature-controlled cold-chain logistics for home collection across Dubai and the Northern Emirates, available daily from 8:00 AM to 11:00 PM. Alternatively, samples can be collected at our DHCC facility.
3. What is the turnaround time for results, and how will I receive them?
The standard turnaround time is 3–4 weeks from the date the sample reaches our laboratory. Results are compiled in a comprehensive molecular genetic report, which is securely delivered electronically to the referring physician and made available to the patient via our encrypted patient portal. A complimentary telephonic post-test counseling session is scheduled to explain the findings.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the stringent regulatory oversight of the Dubai Health Authority (DHA License No: 1143). We strictly comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted at rest and in transit, stored on secure UAE-based servers, and shared only with the patient and their explicitly authorized referring physician.
Clinical & Logistical Metadata
| Test Name | AGT Gene (Renal Tubular Dysgenesis) NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3-5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) – Whole Gene Coverage |
| ICD-10-CM Code | Q60.4 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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