Test Price
2,800 AEDโ Home Collection Available
ACVR1 Gene Sequencing for Fibrodysplasia Ossificans Progressiva (FOP) in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ACVR1 gene test detects mutations in the ACVR1 gene causing Fibrodysplasia Ossificans Progressiva (FOP), an ultra-rare autosomal dominant disorder characterized by progressive heterotopic ossification of soft tissues. This NGS-based test offers comprehensive sequencing of all coding regions and splice sites, establishing a definitive molecular diagnosis critical for management and family planning.
| Feature | Our ACVR1 NGS Test | Closest Alternative (Sanger Hotspot) |
|---|---|---|
| Precision | Full gene sequencing + CNV analysis โ detects all variant types | Limited to exon 6 hotspot; misses ~30% of mutations |
| Method | Next-Generation Sequencing (NGS) | Sanger Sequencing (targeted) |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Diagnostic Rate | >99% in classic FOP | ~70% |
| Price | 2800 AED | Often higher if cascade testing needed |
Physician Insight & Safety Protocols
โGenetic diagnosis of FOP is crucial to avoid harmful interventions such as biopsies that can trigger disease flare-ups. As a DHA-licensed Consultant Medical Geneticist, I emphasize that this test must be interpreted with clinical and radiographic correlation. Patients should remain under specialist care and never alter treatment without professional guidance.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403
Advisory Note
All prescribed therapies must be continued as directed. Stopping medication without medical supervision can lead to serious complications. Always consult your specialist before making any changes to your treatment regimen.
Exclusion Criteria & ER Red Flags
- This genetic test is not suitable for prenatal diagnosis in the absence of a confirmed familial mutation; consult genetic counseling.
- Do not perform invasive procedures (biopsy, surgery) on suspected FOP lesions prior to genetic confirmation due to risk of accelerated ossification.
- If the patient experiences acute soft tissue swelling with pain and redness, consider an FOP flare-up; seek emergency orthopedic or rheumatologic evaluation immediately.
Patient FAQ & Clinical Guidance
1. What is the ACVR1 gene test for FOP and who should consider it?
The ACVR1 gene test analyzes DNA for mutations causing Fibrodysplasia Ossificans Progressiva, an ultra-rare disorder; any individual with unexplained soft tissue masses, progressive joint stiffness, or malformed toes should consider this test for definitive diagnosis.
2. How accurate is this NGS test?
With >99.9% diagnostic sensitivity and specificity, next-generation sequencing detects all ACVR1 pathogenic variants including novel mutations; results are confirmed following ACMG guidelines and ISO 9001 standards.
3. What is the process for home sample collection and result delivery?
A certified phlebotomist visits your home between 8 AM and 11 PM using cold-chain transport; results are securely delivered in 3-4 weeks with an optional teleconsultation to review findings.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All genetic data is handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Licensing & Accreditation: DNA Labs UAE operates under DHA Facility License No. 1143 and is ISO 9001:2015 certified (Certificate No. INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | ACVR1 Gene Sequencing (Fibrodysplasia Ossificans Progressiva / FOP) |
| Price (AED) | 2800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Blood (EDTA Whole Blood) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Sequencing with CNV Analysis |
| ICD-10-CM Code | M61.1 (Myositis Ossificans Progressiva) |
| LOINC Code | 92889-1 (ACVR1 gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address Invariants | DHA License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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