Test Price
2,800 AEDโ Home Collection Available
ABCB6 Gene Dyschromatosis Universalis Hereditaria Type 3 Genetic Test in UAE - DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO-accredited Next-Generation Sequencing (NGS) for the complete coding region of the ABCB6 gene.
- Sample Collection Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary post-test tele-consultation by a DHA-licensed Consultant Medical Genetics for result interpretation and genetic counseling.
- Billing & Insurance: Direct billing verification available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ABCB6 Gene Dyschromatosis Universalis Hereditaria Type 3 Genetic Test is a definitive molecular diagnostic assay utilizing Next-Generation Sequencing (NGS) to analyze the entire coding region of the ABCB6 gene. This test is designed for individuals presenting with suspected inherited pigmentation anomalies. Identifying pathogenic variants in ABCB6 confirms the diagnosis of Dyschromatosis Universalis Hereditaria (DUH) type 3, enabling accurate prognosis, informed family screening, and personalized dermatological management.
| Parameter | Our Service (NGS-Based DUH Type 3) | Alternative Approach (Single-Gene Sanger Sequencing) |
|---|---|---|
| Diagnostic Yield | 99.9% sensitivity; detects SNVs, indels, and copy number variants across all exons. | Limited to targeted hotspots; misses deep intronic mutations and large rearrangements. |
| Methodology | Whole-gene NGS with comprehensive bioinformatics annotation and variant interpretation. | Targeted PCR amplification followed by capillary electrophoresis sequencing. |
| Turnaround Time | 3 โ 4 weeks (DHA-compliant reporting timeline). | 6 โ 8 weeks due to sequential exon analysis. |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I recognize the importance of a precise molecular diagnosis in pigmentary disorders. The ABCB6 NGS test provides a definitive genetic answer for patients with suspected Dyschromatosis Universalis Hereditaria type 3. It is essential to correlate the genetic result with a thorough clinical evaluation and detailed family history. This test empowers families with accurate recurrence risk information and facilitates proactive medical management."
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory & Medication Warning
A genetic test result indicating a predisposition to DUH type 3 does not replace ongoing clinical management. Do not alter or discontinue any prescribed medications or dermatological treatments based solely on a genetic finding. All therapeutic decisions must be discussed with your primary care physician or treating specialist.
Safety & Exclusion Criteria
- Exclusion Criteria: Individuals who have received a blood transfusion within the last 90 days, patients unable to provide informed consent, or those with an active systemic infection requiring hospitalization.
- Emergency Red Flags: Sudden, progressive hyper- or hypopigmentation accompanied by unexplained abdominal pain, mental status changes, or blistering requires immediate emergency evaluation. These symptoms may indicate an acute metabolic or porphyria-related crisis independent of this genetic test.
Patient FAQ & Clinical Guidance
1. What is Dyschromatosis Universalis Hereditaria Type 3 and what causes it?
Dyschromatosis Universalis Hereditaria (DUH) type 3 is a rare inherited skin disorder characterized by a mixture of hyperpigmented and hypopigmented macules distributed across the body. It is caused by pathogenic variants in the ABCB6 gene, which encodes a mitochondrial transporter critical for heme synthesis and normal melanosome function. This test identifies the specific genetic variant responsible for the condition within a family.
2. What sample is required and how is the collection process performed?
The preferred sample type is a peripheral whole blood specimen collected in an EDTA tube. Alternatively, a buccal swab may be accepted for pediatric patients or individuals with difficult venous access. Sample collection can be performed via our VIP Mobile Phlebotomy service at your home or office, operating daily from 8 AM to 11 PM, or at our DHA-licensed facility in Dubai Healthcare City.
3. What does a positive or negative result mean for me and my family?
Positive Result: Confirms a clinical diagnosis of DUH type 3 and indicates that the identified pathogenic variant is heritable. At-risk family members (siblings, children) can pursue targeted variant testing for predictive or diagnostic purposes. Negative Result: Significantly reduces the likelihood of ABCB6-related DUH, but does not exclude all forms of inherited pigmentary disorders. A negative result should be evaluated in the context of the full clinical picture, and other genetic causes may be considered.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Healthcare Compliance
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Your genetic data is processed and stored under strict UAE federal data privacy regulations, ensuring complete confidentiality.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: All digital health records and diagnostic data are managed through secure, audited health information systems.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Clinical testing procedures, patient safety protocols, and the informed consent process are fully compliant with this governing liability framework.
Clinical & Logistical Metadata
| Test Name | ABCB6 Gene Dyschromatosis Universalis Hereditaria Type 3 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks (DHA-Compliant Reporting) |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS), Whole-Gene Sequence Analysis |
| ICD-10-CM Code | Q82.8, L81.9 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians