Test Price
2,800 AEDโ Home Collection Available
ABCA1 Gene HDL Deficiency Type 2 Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM โ 11 PM).
- Clinical Guidance: Complimentary post-test telephonic consultation for result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ABCA1 Gene NGS Test sequences the entire ABCA1 coding region to diagnose familial HDL deficiency type 2 (Tangier disease), characterized by extremely low HDL cholesterol and heightened cardiovascular risk. This test is performed using next-generation sequencing to detect single nucleotide variants, small insertions/deletions, and splice-site mutations across all exons and flanking intronic regions.
| Feature | Our Test (NGS) | Standard Lipid Panel | Targeted Genotyping |
|---|---|---|---|
| Precision | >99.9% analytical sensitivity/specificity | Does not detect genetic cause | Limited to known hotspots |
| Methodology | Next-Generation Sequencing (full gene) | Enzymatic colorimetric | PCR-based SNP arrays |
| Turnaround | 3โ4 Weeks | 24 Hours | 1โ2 Weeks |
| Clinical Utility | Definitive diagnosis, family cascade screening | Phenotypic lipid assessment only | May miss novel mutations |
Physician Insight & Safety Protocols
โGenetic testing for lipid disorders demands careful clinical correlation. A positive ABCA1 result must be interpreted alongside your full lipid profile and family history; a negative result does not exclude other causes of severely low HDL. Please maintain all specialist appointments and never discontinue prescribed statins or other medications without my direct instruction. This test is offered only after appropriate genetic counseling and informed consent.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Medication Advisory
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria for Blood Draw:
- Active febrile illness or systemic infection
- Recent blood transfusion (<3 months)
- Known coagulopathy (inform phlebotomist)
- Pregnancy (notify the collection specialist)
Emergency Red Flags (Seek Immediate Care):
- Sudden chest pain, pressure, or dyspnea
- Signs of stroke: facial droop, unilateral weakness, speech difficulty
- Severe dizziness or loss of consciousness
This test does not replace urgent cardiovascular evaluation. If symptoms arise, proceed to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the ABCA1 Gene HDL Deficiency Type 2 NGS Test?
This NGS test identifies ABCA1 gene mutations causing familial HDL deficiency type 2 (Tangier disease) for accurate diagnosis and personalized cardiovascular risk assessment. The test uses next-generation sequencing to analyze the entire ABCA1 gene, detecting pathogenic variants linked to severe hypoalphalipoproteinemia. It is essential for confirming a genetic diagnosis when HDL cholesterol is persistently below 20 mg/dL, and for guiding family cascade screening.
2. Who should consider this genetic test in the UAE?
Individuals with persistent extremely low HDL cholesterol (below 20 mg/dL), premature coronary artery disease, or a family history of Tangier disease should consider this test. It is also recommended for patients presenting with enlarged orange tonsils, hepatosplenomegaly, or unexplained neuropathy. First-degree relatives of a confirmed carrier benefit from predictive testing after genetic counseling and informed consent in accordance with UAE regulations.
3. How is the test performed and how long do results take?
A simple blood sample is collected via VIP Mobile Phlebotomy at your home or office between 8 AM and 11 PM. The sample is transported under temperature-controlled cold chain to our ISO-certified laboratory. Once next-generation sequencing and bioinformatics analysis are complete, a comprehensive report is delivered within 3 to 4 weeks. A complimentary teleconsultation with a Consultant Medical Geneticist is scheduled to explain your results and provide clinical recommendations.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Data Protection: All personal and genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Patient consent and medical liability protections follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory Accreditation: ISO 9001:2015 certified (Certificate No. INT/EGQ/2509DA/3139). All genetic analysis is performed within the UAE.
For booking or insurance verification: WhatsApp +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | ABCA1 Gene Sequencing โ Familial HDL Deficiency Type 2 (Tangier Disease) |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3โ5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (Illumina platform) โ full coding region and splice sites |
| ICD-10-CM Code | E78.6 (Lipoprotein deficiency) |
| LOINC Code | 21301-0 (Genetic test report) |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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