Test Price
2,800 AEDโ Home Collection Available
ZIC5 Gene Sequencing Test (NGS) for Congenital Brain Disorders in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: The ZIC5 gene sequencing test utilises next-generation sequencing (NGS) to identify pathogenic variants associated with congenital brain malformations, delivering 99.9% diagnostic sensitivity through an ISO 9001:2015 accredited laboratory process. The service includes VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection, mandatory pre- and post-test genetic counselling, and telephonic clinical guidance. Insurance direct billing verification is available via WhatsApp at +971 54 548 8731.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ZIC5 gene test screens for pathogenic variants linked to congenital brain abnormalities and dysmorphic features using next-generation sequencing. This comprehensive analysis aids neurologists and geneticists in diagnosing ZIC5-related brain malformations and tailoring patient management. The methodology covers the full coding region and splice sites of the ZIC5 gene, ensuring high-resolution detection of single nucleotide variants and small insertions or deletions.
| Feature | Our Test (ZIC5 NGS) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | ~90% (targeted panels) |
| Methodology | Next-Generation Sequencing (Full Gene) | Sanger (specific exons) / Limited NGS |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Price & Support | 2,800 AED + Pre/Post Genetic Counselling | 3,500 AED (no counselling) |
Physician Insight & Safety Protocols
โInterpreting ZIC5 variants requires careful correlation with the clinical phenotype and detailed family pedigree analysis. A positive result confirms the molecular diagnosis, while a negative result does not exclude other genetic contributors. All results should be discussed with a qualified genetic counsellor to guide informed clinical management and family planning decisions.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication & Clinical Precautions
Important Clinical Advisory
Do not discontinue any prescribed medication without consulting your physician. This genetic test is intended for diagnostic confirmation and should never replace urgent clinical evaluation.
Exclusion Criteria & Emergency Indicators
Exclusion Criteria
- Active bleeding disorder or inability to provide a blood or DNA sample.
- Lack of informed consent, particularly for minors (in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability).
Emergency Red Flags
- Sudden neurological deterioration, new-onset seizures, or loss of consciousness โ seek immediate emergency medical care.
- This test is not a substitute for urgent clinical evaluation.
Patient FAQ & Clinical Guidance
1. What does the ZIC5 gene test detect, and who should consider it?
This test detects pathogenic variants in the ZIC5 gene associated with congenital brain malformations and developmental delays. It is recommended for children presenting with unexplained dysmorphic features, neurological deficits, or a family history of congenital brain anomalies, under the guidance of a specialist.
2. How is the test performed and what preparation is required?
A whole blood sample, extracted DNA, or a dried blood spot on an FTA card is collected by our ISO-certified VIP Mobile Phlebotomy team under temperature-controlled cold-chain conditions. No fasting is required; however, a mandatory pre-test genetic counselling session is scheduled to document the pedigree and review complete clinical history.
3. What are the limitations, and what happens after I receive results?
A negative result does not rule out other genetic causes; variants of uncertain significance may require additional family segregation studies. Post-test, you will receive a telephonic clinical guidance session with a genetic counsellor to discuss the implications, recurrence risks, and appropriate next steps.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes. Patient consent is obtained and managed in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring full transparency and legal protection throughout the testing lifecycle.
Clinical & Logistical Metadata
| Test Name | ZIC5 Gene Sequencing Test (NGS) for Congenital Brain Disorders |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | Q04.8 |
| LOINC Code | 51966-2 |
| DHA Facility License & Laboratory Address | DNA Labs UAE | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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