Test Price
4,000 AED✅ Home Collection Available
AAAS Full Gene Sequence Analysis (Allogrove Syndrome) in UAE | 4000 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Laboratory (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available (8 AM – 11 PM, daily).
- Clinical Guidance: Complimentary Post-Test Telephonic Interpretation by a licensed Clinical Geneticist.
- Insurance Support: Direct Billing Verification via WhatsApp +971 54 548 8731 (MOHAP compliant).
Test Overview & Methodology
This diagnostic test employs bidirectional Sanger sequencing to interrogate the entire coding region and splice junctions of the AAAS gene, providing definitive molecular diagnosis of Allogrove (Triple A) Syndrome with 99.9% sensitivity. Sanger sequencing remains the gold standard for detecting point mutations, small insertions, and deletions, offering unparalleled accuracy compared to targeted next-generation panels.
| Feature | Our AAAS Full Gene Sequence Analysis | Closest Alternative (NGS Panel) |
|---|---|---|
| Methodology | Bidirectional Sanger Sequencing (Gold Standard) | Next-Generation Sequencing (Targeted Panel) |
| Coverage | Entire gene, including deep intronic/exonic boundaries | Limited to selected exons; may miss rare variants |
| Turnaround Time | 2-3 Weeks | 2-4 Weeks |
| Clinical Confidence | 99.9% Diagnostic Sensitivity | ~85-95% for known variants |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasize that the AAAS full gene sequence analysis provides definitive diagnosis for Allogrove Syndrome. Sanger sequencing remains the gold standard for detecting point mutations and small indels. However, all results must be integrated with clinical findings and family history. Early diagnosis allows for proactive multidisciplinary management, including endocrine, gastroenterology, and ophthalmology follow-up.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre-Test Counseling Advisory
Genetic testing should be accompanied by pre- and post-test genetic counseling to ensure informed consent and understanding of implications. Discuss your personal and family history with a qualified genetic counselor or specialist before proceeding with this molecular analysis.
Exclusion Criteria & Safety
This test is not a substitute for comprehensive clinical evaluation. For prenatal sampling (amniocentesis, chorionic villus sampling), the procedure must be performed by a qualified specialist in a licensed hospital setting after thorough counseling. Seek immediate medical attention if you experience severe pain, bleeding, or fever after any invasive procedure. Peripheral blood collection carries minimal risks; apply pressure if minor hematoma occurs.
Patient FAQ & Clinical Guidance
1. What is the AAAS Full Gene Sequence Analysis?
This diagnostic test sequences the entire AAAS gene to detect mutations responsible for Allogrove (Triple A) Syndrome, a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia, and alacrima. Early molecular diagnosis guides targeted treatment and family planning.
2. How is the sample collected, and can I have it done at home?
The standard sample is a simple peripheral blood draw. Our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service is available daily from 8 AM to 11 PM across the UAE. For prenatal cases, amniotic fluid, chorionic villi, or cord blood must be collected strictly within a hospital setting by a qualified specialist.
3. How long for results and how will I understand them?
Results are typically ready within 2-3 weeks from sample receipt. Your secure electronic report will be followed by a complimentary teleconsultation with a licensed clinical geneticist who will explain findings in plain language and outline recommended next steps.
4. Will this test detect all possible mutations?
Sanger sequencing covers the entire coding region and splice junctions of the AAAS gene, detecting point mutations, small insertions, and deletions with 99.9% sensitivity. However, large deletions, duplications, or deep intronic variants may not be detected; if clinical suspicion persists, complementary methods such as MLPA or whole-genome sequencing may be recommended by your genetic specialist.
UAE Regulatory & Data Privacy Adherence
Data Protection & Healthcare Compliance
- Your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DNA Labs UAE operates under DHA Facility License Number 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE).
- All laboratory procedures follow ISO 9001:2015 Quality Management standards (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | AAAS Full Gene Sequence Analysis (Allogrove Syndrome) |
| Price (AED) | 4,000 AED |
| Turnaround Time | 2–3 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Home Phlebotomy Available); Prenatal: Amniotic Fluid, Chorionic Villi, or Cord Blood (Hospital Extraction Only) |
| Methodology Used | Bidirectional Sanger Sequencing (Gold Standard) |
| ICD-10-CM Code | Q87.8, E25.8, Z13.79 |
| LOINC Code | 93307-9 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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