Test Price
3,600 AEDโ Home Collection Available
Crigler-Najjar Syndrome Single Gene Sequencing in UAE | 3600 AED | DHA Licensed
Executive Summary & Core Metrics
- โ 99.9% diagnostic sensitivity through ISO 9001:2015 certified processing.
- โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM.
- โ Post-test clinical counseling via phone consultation for result interpretation.
- โ Direct insurance verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This single gene Sanger sequencing test detects UGT1A1 mutations causing Crigler-Najjar syndrome, providing definitive diagnosis for jaundice and bilirubin metabolism disorders. This is performed for prenatal, carrier, and confirmatory testing.
| Parameter | Our Crigler-Najjar Sanger | Closest Alternative (Multi-gene NGS Panel) |
|---|---|---|
| Precision | 99.9% sensitivity; gold-standard for single gene | May miss deep intronic variants; 95โ98% coverage |
| Methodology | Sanger Sequencing (bidirectional) | Next-Generation Sequencing (short reads) |
| Turnaround Time | 7โ8 working days | 10โ14 working days |
| Price | 3,600 AED | 4,500โ5,500 AED |
Physician Insight & Safety Protocols
โGenetic test results must always be correlated with clinical symptoms and family history. A positive mutation confirms Crigler-Najjar syndrome and guides early intervention including phototherapy or liver transplant planning. Do not alter any treatment without proper medical advice.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor.
Safety & Exclusion Criteria
- Exclusion: acute febrile illness, recent blood transfusion (<2 weeks), neonates <2 kg (may require modified collection).
- ER Red Flags: If you or your child develop worsening jaundice, lethargy, poor feeding, or arching of the back (opisthotonos), seek immediate emergency care.
- All results must be reviewed by a qualified geneticist or hepatologist to avoid misinterpretation.
Patient FAQ & Clinical Guidance
1. What is Crigler-Najjar syndrome, and how does genetic testing help?
Genetic sequencing identifies UGT1A1 mutations causing severe unconjugated hyperbilirubinemia, enabling early diagnosis, family screening, and tailored management to prevent kernicterus.
2. How accurate is Sanger sequencing for Crigler-Najjar?
With 99.9% analytical sensitivity, Sanger sequencing reliably detects all coding region variants in UGT1A1, establishing a definitive molecular diagnosis in most cases.
3. Can I collect the sample at home, and is insurance accepted?
Our VIP Mobile Phlebotomy service collects blood at your home, hotel, or office across all Emirates. We verify coverage directly via WhatsApp before your appointment.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License 1143. All genetic testing and health data processing comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) ensures quality management.
Clinical & Logistical Metadata
| Test Name | Crigler-Najjar Syndrome (UGT1A1) Single Gene Sequencing |
| Price (AED) | 3,600 AED |
| Turnaround Time | 7โ8 working days |
| Sample Type / Matrix | Whole Blood (peripheral) |
| Methodology Used | Sanger Sequencing (bidirectional) |
| ICD-10-CM Code | E80.5 |
| LOINC Code | 21626-6 |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians