Test Price
2,800 AED✅ Home Collection Available
ZIC3 Gene Heterotaxy Visceral Type 1 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189/9001 Accredited Processing.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Result Interpretation with a DHA-licensed specialist.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Core Metrics: 2800 AED all-inclusive, result delivery within 21–28 calendar days, and mandatory pre-test genetic counselling session.
Test Overview & Methodology
The ZIC3 gene Next-Generation Sequencing (NGS) test identifies pathogenic variants associated with visceral heterotaxy type 1, a congenital disorder disrupting normal left-right organ laterality. This high-resolution genetic analysis enables early diagnosis, risk stratification, and informed reproductive planning. The methodology employs targeted NGS with full-gene coverage, detecting single nucleotide variants, insertions, deletions, and copy number variants at a mean depth exceeding 200x.
| Feature | Our Test (NGS) | Closest Alternative (Sanger / Exome) |
|---|---|---|
| Methodology | Targeted NGS (ZIC3 full gene) | Sanger sequencing or untargeted WES |
| Variant Detection | SNVs, indels, copy number variants (high depth) | Limited to point mutations (Sanger); may miss deep intronic CNVs (WES) |
| Turnaround Time | 3–4 Weeks | 2–6 Weeks (WES often slower) |
| Detection Rate | 99.9% sensitivity for ZIC3 coding variants | Variable; Sanger detects only known familial variants |
Physician Insight & Safety Protocols
“A positive ZIC3 finding must be integrated with echocardiographic, abdominal imaging, and comprehensive clinical data before a final diagnosis of visceral heterotaxy type 1 is established. Genetic sequencing alone provides one critical piece of the diagnostic framework; it does not replace multidisciplinary evaluation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Warning
⚠️ Medication and Treatment Continuity
Never halt, adjust, or interrupt any prescribed medication or ongoing treatment protocol for yourself or a dependent child based solely on genetic test results. All therapeutic decisions must be reviewed and approved by the treating physician during a dedicated follow-up consultation.
Exclusion Criteria & Emergency Red Flags
🔹 Pre-Testing Exclusion Criteria
- Inability to provide informed consent (legally authorized representative required for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Sample contamination or hemolysis compromising DNA integrity.
- Non-viable sample on FTA card due to insufficient blood volume.
- Active major infection or immune dysregulation causing altered clonal hematopoiesis (may be rescheduled after clinical clearance).
🔹 Situations Requiring Immediate Medical Attention
- New-onset cyanosis, respiratory distress, or feeding intolerance in an infant.
- Severe cardiac arrhythmia or signs of intestinal malrotation (bilious vomiting).
- Sudden loss of consciousness or seizures – call 998 (UAE Ambulance).
This test is for genetic evaluation only; it does not replace emergency medical care.
Patient FAQ & Clinical Guidance
1. What is the ZIC3 gene heterotaxy test and why is it ordered?
This targeted NGS test sequences the ZIC3 gene to identify pathogenic variants causing visceral heterotaxy type 1, helping to confirm the genetic basis of abnormal organ laterality. Clinicians typically order it for infants or children with congenital heart defects, splenic anomalies, or situs ambiguus seen on imaging to guide surgical planning and family counseling.
2. How is the sample collected and what is the turnaround time?
A standard peripheral whole blood draw, one drop on an FTA card, or purified genomic DNA can be submitted. Our certified phlebotomist performs a temperature-controlled home visit between 8 AM and 11 PM using validated cold-chain transport. The laboratory processes the specimen with NGS and delivers results within 3 to 4 weeks, accompanied by a telephonic explanation of findings from a genetics specialist.
3. Is this test covered by insurance in the UAE and how can I verify?
Many UAE insurers cover the ZIC3 NGS test when a DHA-licensed specialist provides a requisition. We offer direct billing verification via WhatsApp at +971 54 548 8731. Send your insurance card and physician referral, and our team will confirm coverage and necessary pre-approvals before the collection is scheduled.
4. What happens after the results are ready?
A clinical geneticist reviews each report and contacts you by phone to explain the findings, their implications for organ laterality and associated anomalies, and recommended next steps. A follow-up letter is sent to your referring physician to coordinate further imaging, cardiology, or surgical referrals as indicated.
UAE Regulatory & Data Privacy Adherence
All genetic data processing and storage at DNA Labs UAE complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent for genetic analysis is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143. No genetic data is shared with third parties without explicit written authorization.
Clinical & Logistical Metadata
| Test Name | ZIC3 Gene Heterotaxy Visceral Type 1 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), FTA Card, or Extracted Genomic DNA |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) – Full ZIC3 Gene Coverage |
| ICD-10-CM Code | Q89.3 |
| LOINC Code | 81265-5 |
| DHA Facility License & Address | License No: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians