Test Price
2,800 AED✅ Home Collection Available
WRN Gene (Werner Syndrome) Genetic Test in UAE | 2800 AED | DHA-Licensed Laboratory
Executive Summary & Core Metrics
Clinical Genetic Analysis for Werner Syndrome
This advanced Next-Generation Sequencing test decodes the entire WRN gene to provide an accurate diagnosis of Werner syndrome with 99.9% diagnostic sensitivity under ISO-certified lab conditions. The test is indicated for individuals with clinical suspicion of Werner syndrome, family history of the condition, or for carrier screening purposes. Results are interpreted in accordance with DHA-mandated variant classification guidelines, ensuring clinical validity and regulatory alignment within the UAE healthcare framework.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM)
- Telephonic Post-Test Clinical Guidance and Genetic Counseling
- Direct Insurance Billing Verification via WhatsApp: +971 54 548 8731
- Full Compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
Test Overview & Methodology
The WRN Gene (Werner Syndrome) Genetic Test utilizes high-coverage next-generation sequencing to analyze all coding exons and flanking intronic regions of the WRN gene. This comprehensive approach detects single nucleotide variants, small insertions and deletions, and copy number alterations responsible for Werner syndrome. The test achieves 99.9% diagnostic sensitivity, significantly reducing false-negative rates compared to conventional single-exon sequencing methods. Each result is reviewed by a Consultant Medical Genetics specialist and reported with variant classifications aligned to ACMG and DHA guidelines.
| Feature | Our Test (WRN Gene NGS) | Closest Alternative (Single-Exon Sequencing) |
|---|---|---|
| Methodology | NGS (Full Gene Coverage) | Sanger Sequencing (Limited Regions) |
| Precision | 99.9% Diagnostic Sensitivity | ~95% due to missed deep intronic variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Options | Blood, Extracted DNA, FTA Card | Blood Only |
Physician Insight & Safety Protocols
Insight from Consultant Medical Genetics
"As a Consultant Medical Genetics specialist, I emphasize that comprehensive WRN gene analysis via next-generation sequencing provides definitive molecular confirmation of Werner syndrome when clinical suspicion exists. Results must always be interpreted within the full context of the patient's medical history, physical examination findings, and family pedigree. A negative result does not entirely exclude the possibility of rare deep intronic or regulatory variants that may fall outside standard detection parameters. We strongly recommend post-test genetic counseling for all patients undergoing this analysis to ensure appropriate understanding of implications for both the individual and at-risk family members."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Safety Advisory
Important Clinical Notice: Do not discontinue or adjust any prescribed medication or treatment regimen without consulting your treating physician. This genetic test provides diagnostic information and is not a substitute for ongoing clinical management or emergency medical care. All clinical decisions should be made jointly with a qualified healthcare provider.
Exclusion Criteria & Urgent Red Flags
- Not suitable for patients who have undergone allogeneic bone marrow transplant within the last 6 months due to risk of maternal cell contamination interfering with germline analysis.
- Individuals with severe bleeding disorders require explicit physician clearance before blood sample collection.
- If the patient experiences rapid physical decline, unexplained bruising, or signs of acute myelodysplasia, seek immediate emergency medical attention — do not wait for test results.
Patient FAQ & Clinical Guidance
1. What does the WRN Gene NGS test detect, and how is it different from routine genetic panels?
This test sequences the entire WRN gene using high-coverage NGS, identifying single nucleotide variants, small indels, and copy number changes responsible for Werner syndrome. Many standard multi-gene panels miss these alterations due to limited exon focus. By analyzing all coding and flanking intronic regions, we reduce false negatives, enabling definitive diagnosis and tailored cancer surveillance. Patients in the UAE receive a report aligned with DHA-mandated variant interpretation guidelines and ACMG standards.
2. What is Werner syndrome, and why is this genetic test necessary?
Werner syndrome is a rare autosomal recessive disorder characterized by premature aging, increased risk of malignancies, and accelerated cardiovascular disease. Caused by pathogenic variants in the WRN gene, the condition often goes undiagnosed until later stages. This NGS-based test provides definitive molecular confirmation, enabling early intervention, regular cancer surveillance, and informed family planning. Early diagnosis significantly improves clinical outcomes through proactive management of age-related complications.
3. Can this test be performed on a child, and what are the UAE legal requirements?
Predictive genetic testing in minors requires explicit parental consent and a determination that early diagnosis serves the child's best medical interest, as outlined under UAE Federal Law No. 2 of 2019 and the principles of medical liability per Federal Decree-Law No. 4 of 2016. A mandatory pediatric genetic counseling session is conducted before sample collection to ensure that results are disclosed appropriately and that any potential psychological impact is mitigated. Our clinical team provides a DHA-compliant consent form and coordinates pre-test counseling under the supervision of our Consultant Medical Genetics specialist.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
All genetic testing services provided by DNA Labs UAE operate in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring that your genetic data is processed, stored, and transmitted with the highest standards of confidentiality and security. Additionally, our laboratory adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, which governs the digital handling of health information. Clinical safety and patient consent protocols are aligned with Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing that all procedures are conducted with full informed consent and medical accountability.
Clinical & Logistical Metadata
| Test Name | WRN Gene (Werner Syndrome) Genetic Test – NGS Full Gene Coverage |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | E34.8 (Werner's Syndrome) |
| LOINC Code | 81247-9 (WRN gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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