Test Price
2,800 AEDโ Home Collection Available
TNFRSF11B Gene (Paget Disease, Juvenile) Genetic Test โ 2,800 AED
Executive Summary & Core Metrics
Core Metrics
- Accuracy Guarantee: >99.9% diagnostic sensitivity via ISO-accredited next-generation sequencing (NGS) processing.
- Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test counselling provided by Consultant Medical Genetics.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- DHA Compliance: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
This NGS-based genetic test analyses the full coding sequence of the TNFRSF11B gene, providing definitive molecular confirmation of juvenile Paget disease (hereditary hyperphosphatasia) and enabling targeted family screening. In the UAE, our DHA-endorsed protocol combines the highest analytical sensitivity with strict compliance to data privacy and health technology standards.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Gene Coverage | Full exonic & splice regions | Limited to hotspot mutations |
| Analytical Sensitivity | >99.9% for single nucleotide variants | ~95% for known mutations only |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks |
| Price | 2,800 AED | ~3,500 AED |
Methodology: Illumina NovaSeq 6000 platform, validated under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics, I emphasise that a disease-causing mutation in TNFRSF11B is diagnostic for juvenile Paget disease. However, results must be correlated with clinical manifestations such as progressive bone deformities, early-onset hearing loss, and elevated alkaline phosphatase. This test is most valuable when interpreted alongside thorough genetic counselling to mitigate anxiety and guide early intervention, including bisphosphonate therapy and audiological surveillance.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication and Clinical Management
Do not discontinue prescribed medication (e.g., bisphosphonates, calcitriol) without consulting your doctor. Genetic results inform, but do not replace, clinical management. Always follow your specialistโs guidance.
Exclusion Criteria & Emergency Red Flags
- Sample Rejection: Clotted blood, insufficient volume, degraded DNA, or improper FTA card storage.
- Urgent Referral Signs: Sudden hearing loss, acute vision changes (optic nerve compression), pathological fracture with neurological compromise, or cranial nerve palsies.
- Paediatric Consent: All minors require guardian consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does the TNFRSF11B gene test detect?
This test sequences the TNFRSF11B gene to confirm juvenile Paget disease (hereditary hyperphosphatasia), enabling precise treatment decisions and targeted family screening.
2. How is the sample collected?
We provide VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM. The sample is a standard peripheral whole blood draw or FTA card blood spot. Phlebotomy is performed by a certified technician.
3. What is the cost and turnaround time?
The test costs 2,800 AED with results delivered within 3โ4 weeks. Direct insurance verification is available via WhatsApp.
4. Will I need a follow-up consultation?
Yes, our service includes telephonic post-test clinical guidance from a Consultant Medical Genetics to discuss results and next steps.
UAE Regulatory & Data Privacy Adherence
This test is performed under the strict oversight of the Dubai Health Authority (DHA Facility License No. 1143). We adhere to:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for telehealth and digital health records.
- Federal Decree-Law No. 4 of 2016 on Medical Liability for patient consent and clinical safety standards.
All samples are processed in our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139) located at Premier 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | TNFRSF11B Gene (Paget Disease, Juvenile) Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral whole blood, FTA card blood spot (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq 6000 |
| ICD-10-CM Code | M88.89 (Juvenile Paget disease, multiple sites) |
| LOINC Code | 81247-9 (Sequence analysis of specific gene) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians