Test Price
2,800 AED✅ Home Collection Available
TJP2 Gene Hypercholanemia Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing and stringent QA protocols.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post‑test result interpretation with a specialist to navigate next steps.
- Insurance Integration: Direct Billing Verification via WhatsApp at +971 54 548 8731 – we handle the paperwork.
- Regulatory Integrity: Fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
This next‑generation sequencing assay interrogates the entire coding region of the TJP2 gene to identify pathogenic variants linked to progressive familial intrahepatic cholestasis type 4 (PFIC4), a severe metabolic disorder causing bile acid retention and liver injury. Early detection enables targeted management including ursodeoxycholic acid therapy or liver transplantation evaluation.
| Feature | Our TJP2 NGS Test (UAE) | Closest Biochemical Alternative |
|---|---|---|
| Precision | >99.9% diagnostic sensitivity; full gene coverage | Indirect; elevated serum bile acids may be non‑specific |
| Methodology | High‑Fidelity Next Generation Sequencing (NGS) | Enzymatic colorimetric assay (bile acid quantification) |
| Turnaround Time | 3–4 weeks (expedited reporting possible) | 1–2 days (but no genetic insight) |
Physician Insight & Safety Protocols
“As a clinical geneticist, I emphasize that results from this NGS test must be interpreted within the full clinical context, including family history, liver function tests, and imaging. Pathogenic variants in TJP2 confirm PFIC4, but many variants are of uncertain significance. A hepatology consultation is recommended to guide treatment decisions without undue alarm.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Do Not Discontinue Prescribed Medication
⚠️ Do not discontinue prescribed medication without consulting your doctor.
Safety Exclusions & Emergency Red Flags
- Exclusion criteria: Recent blood transfusion (≤4 weeks), insufficient DNA yield, inability to provide informed consent.
- ER Red Flags: Sudden jaundice, intense pruritus, right‑upper‑quadrant pain, or signs of decompensated liver disease (ascites, encephalopathy) — seek immediate medical attention.
- Pediatric caution: All minor testing follows Federal Decree‑Law No. 4 of 2016 on Medical Liability; guardian consent is mandatory.
Patient FAQ & Clinical Guidance
1. What does the TJP2 hypercholanemia test detect, and why is it ordered?
It detects pathogenic DNA variants in the TJP2 gene that cause bile acid transport defects, leading to progressive cholestasis and liver disease. Physicians order the test to confirm a diagnosis of PFIC4 in patients with unexplained cholestasis, abnormal liver function, or a family history of hypercholanemia. Early identification can guide treatment, including ursodeoxycholic acid or liver transplantation evaluation.
2. How should I prepare for the DNA collection, and is the procedure painful?
Preparation requires only a simple genetic counseling session to draw a pedigree chart; no fasting or medication changes are needed. Our phlebotomist collects a small blood sample (or a single drop on an FTA card) using pain‑minimizing techniques, causing only mild discomfort. Extracted DNA from buccal swabs can also be submitted with prior arrangement.
3. Can I use my insurance for the 2800 AED cost, and how quickly do I receive results?
Yes, direct billing verification is available via WhatsApp at +971 54 548 8731; pre‑approval is often obtained within 24 hours. Turnaround time for the NGS is 3–4 weeks, with a preliminary verbal update possible for urgent clinical cases. We dispatch the final certified report electronically and offer a tele‑consultation to explain findings.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Health Information Protection
This test is performed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for diagnostic purposes. No information is shared without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | TJP2 Gene Hypercholanemia Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD‑10‑CM Code | K76.8 (Other specified diseases of liver) |
| LOINC Code | 81247-9 (Genetic variant report) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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