Test Price
2,800 AED✅ Home Collection Available
TFG Gene (SPG57) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited NGS with Sanger Confirmation
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM)
- Clinical Guidance: Complimentary Telephonic Post‑Test Interpretation by DHA‑Licensed Genetic Counselor
- Insurance: Direct Billing Verification — WhatsApp +971 54 548 8731
- Facility License: DHA License No. 1143 • ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
Test Overview & Methodology
The TFG Gene SPG57 Genetic Test is a single‑gene sequencing assay that detects pathogenic variants in the TFG gene, which is associated with autosomal recessive hereditary spastic paraplegia type 57 (SPG57). This test aids neurologists and geneticists in confirming a clinical diagnosis, guiding family planning, and distinguishing SPG57 from other neurological disorders.
| Feature | Our TFG SPG57 NGS Test | Closest Alternative – Whole Exome Sequencing |
|---|---|---|
| Precision | Targeted deep coverage of the entire TFG coding region; specifically designed for SPG57 | Broad analysis of all exons; may return incidental findings unrelated to spastic paraplegia |
| Methodology | NGS + orthogonal Sanger validation of any clinically relevant variant | NGS only; Sanger validation typically not performed unless a candidate variant is prioritized |
| Turnaround Speed | 3–4 Weeks | 8–12 Weeks (standard reporting time) |
Physician Insight & Safety Protocols
Note from Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA License: 9294403):
“The TFG gene test is a precise molecular tool for confirming SPG57 when clinical signs and family history point toward hereditary spastic paraplegia. Interpretation must be correlated with neurological examination and imaging. A negative result does not exclude deep intronic or regulatory variants, so comprehensive post‑test counseling is essential. Our team is available to discuss every result in detail.”
Safety Advisory
⚠ Important
Do not discontinue any prescribed neurological medications without consulting your treating physician. The genetic test is for diagnostic clarification and does not replace current therapy.
Exclusion Criteria
- Exclusion: Recent hematopoietic stem cell transplant (<6 weeks) may lead to donor DNA contamination; postpone testing.
- Exclusion: Unwillingness to undergo mandatory pre‑test genetic counseling as per UAE regulations.
- ER Red Flag: If the patient develops acute paralysis, loss of bladder/bowel control, or sudden vision loss, seek emergency care immediately — genetic testing is not an emergency intervention.
Patient FAQ & Clinical Guidance
1. What is the purpose of the TFG gene SPG57 DNA test?
The test confirms hereditary spastic paraplegia type 57 by detecting pathogenic TFG mutations, supporting treatment and family planning. It is a definitive molecular diagnostic tool for symptomatic individuals with a suspected clinical picture; it is not designed as a screening test for asymptomatic healthy people. A positive result guides tailored rehabilitation and genetic risk assessment for relatives.
2. How is the sample collected and is there any preparation needed?
Sample is collected via standard peripheral blood draw or dried blood spot on FTA card by a certified phlebotomist during a mobile home visit. No fasting or medication changes are required. A mandatory pre‑test genetic counseling session (remote or in‑person) is arranged before sampling to document family history and provide informed consent in compliance with UAE law.
3. What does a positive result mean and what steps should follow?
A positive result links a pathogenic TFG mutation to your clinical diagnosis, requiring immediate genetic counseling and neurology referral. This confirms the molecular cause of your symptoms and enables a precise management plan, including physiotherapy, spasticity control, and family cascade testing. We provide a complimentary tele‑interpretation session with a specialized genetic counselor to explain next steps.
UAE Regulatory & Data Privacy Adherence
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL): Genetic data is classified as sensitive personal information; all samples and results are anonymized, encrypted, and processed strictly within a compliant data‑protection framework.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Our digital health platforms adhere to strict data security and interoperability standards.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability: Informed consent is obtained before any clinical procedure, including genetic testing.
- ISO 9001:2015 Quality Certification: Certificate INT/EGQ/2509DA/3139 — confirming globally recognized quality management for every test step.
Clinical & Logistical Metadata
| Test Name | TFG Gene (SPG57) Genetic Test – Single Gene Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | NGS (Next‑Generation Sequencing) + Sanger Confirmation |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 91518-1 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 · Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – Corporate Lab: DNA Labs UAE |
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