Test Price
2,800 AED✅ Home Collection Available
TFG Gene (SPG57) Genetic Test in UAE | AED 2,800 | 2026 DHA Guidelines
تحليل جين TFG (SPG57) بتقنية التسلسل من الجيل التالي - الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
Executive Clinical Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited NGS with Sanger Confirmation
- Premium Logistics: Hospital‑Grade Home Collection (8 AM–11 PM) with Cold‑Chain Transport & VIP Mobile Phlebotomy
- Clinical Guidance: Complimentary Telephonic Post‑Test Interpretation by DHA‑Licensed Genetic Counselor
- Insurance: Direct Billing Verification — WhatsApp +971 54 548 8731
- Facility License: 9834453 • ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
يُقدِّم هذا الاختبار تشخيصاً جينياً دقيقاً لمرض الشلل النصفي التشنجي الوراثي من النوع السابع والخمسين (SPG57) باستخدام تقنية التسلسل من الجيل التالي، مع خدمات سحب الدم المنزلي المُبرَّد بمعايير ISO 9001:2015 وإرشاد طبي هاتفي ما بعد الفحص. الامتثال الكامل للمرسوم بقانون اتحادي رقم 41 لعام 2024 وقانون حماية البيانات الشخصية.
Test Overview & Clinical Utility
The TFG Gene SPG57 Genetic Test is a single‑gene sequencing assay that detects pathogenic variants in the TFG gene, which is associated with autosomal recessive hereditary spastic paraplegia type 57 (SPG57). This test aids neurologists and geneticists in confirming a clinical diagnosis, guiding family planning, and distinguishing SPG57 from other neurological disorders. يساعد هذا الفحص في تأكيد تشخيص الشلل النصفي التشنجي الوراثي من النوع 57 وتوجيه الاستشارة الوراثية للأسرة المعنية.
| Feature | Our TFG SPG57 NGS Test | Closest Alternative – Whole Exome Sequencing |
|---|---|---|
| Precision | Targeted deep coverage of the entire TFG coding region; specifically designed for SPG57 | Broad analysis of all exons; may return incidental findings unrelated to spastic paraplegia |
| Methodology | NGS + orthogonal Sanger validation of any clinically relevant variant | NGS only; Sanger validation typically not performed unless a candidate variant is prioritized |
| Turnaround Speed | 3–4 Weeks | 8–12 Weeks (standard reporting time) |
Physician Insight & Safety Protocol
Note from Dr. Prabhakar Reddy, Consultant Neurologist (DHA License: 61713011):
“This test is a pivotal step when clinical signs and family history suggest SPG57, yet it must be interpreted alongside a thorough neurological exam and MRI findings. A negative result does not exclude the condition entirely, particularly in cases of deep intronic variants or novel mutations, so we always recommend a detailed post‑test counseling session. Please do not hesitate to reach out to our team for a personalized explanation of your results.”
⚠ Medication Warning
Do not discontinue any prescribed neurological medications without consulting your treating physician. The genetic test is for diagnostic clarification and does not replace current therapy.
Patient Safety & Exclusion Criteria
- Exclusion: Recent hematopoietic stem cell transplant (<6 weeks) may lead to donor DNA contamination; postpone testing.
- Exclusion: Unwillingness to undergo mandatory pre‑test genetic counseling as per UAE Federal Decree‑Law No. 41/2024.
- ER Red Flag: If the patient develops acute paralysis, loss of bladder/bowel control, or sudden vision loss, seek emergency care immediately — genetic testing is not an emergency intervention.
UAE Regulatory & Data Privacy Assurance
- Federal Decree‑Law No. 41 of 2024 (Article 87): Mandates pre‑ and post‑test genetic counseling; our service includes compulsory counseling sessions.
- Child Protection Law (CDS 2026): Minors require presence of a legal guardian and documented consent; sample collection will not proceed without them.
- UAE Personal Data Protection Law (PDPL): Genetic data is classified as sensitive personal information; all samples and results are anonymized, encrypted, and processed strictly within a compliant data‑protection framework.
- ISO 9001:2015 Quality Certification: Certificate INT/EGQ/2509DA/3139 — confirming globally recognized quality management for every test step.
Frequently Asked Questions
What is the purpose of the TFG gene SPG57 DNA test?
The test confirms hereditary spastic paraplegia type 57 by detecting pathogenic TFG mutations, supporting treatment and family planning. It is a definitive molecular diagnostic tool for symptomatic individuals with a suspected clinical picture; it is not designed as a screening test for asymptomatic healthy people. A positive result guides tailored rehabilitation and genetic risk assessment for relatives.
الغرض من التحليل هو تأكيد تشخيص الشلل النصفي التشنجي الوراثي من النوع 57 عبر كشف الطفرات الممرضة في جين TFG، وهو اختبار تشخيصي للأشخاص الذين تظهر عليهم الأعراض وليس فحصاً روتينياً للأصحاء.
How is the sample collected and is there any preparation needed?
Home blood or FTA card collection is performed by a certified phlebotomist; no fasting or medication changes required. Our mobile team arrives with cold‑chain equipment for stable transport. A mandatory pre‑ genetic counseling session (remote or in‑person) is arranged before sampling to document family history and provide informed consent in compliance with UAE law.
يتم جمع العينة إما بسحب عينة دم وريدي أو بوضع نقطة دم على بطاقة FTA، ولا يتطلب صياماً أو تغييراً في الأدوية. تُجرى جلسة استشارة وراثية مسبقة إلزامية لتوثيق التاريخ العائلي بموافقة خطية وفقاً للقانون الإماراتي.
What does a positive result mean and what steps should follow?
A positive result links a pathogenic TFG mutation to your clinical diagnosis, requiring immediate genetic counseling and neurology referral. This confirms the molecular cause of your symptoms and enables a precise management plan, including physiotherapy, spasticity control, and family cascade testing. We provide a complimentary tele‑interpretation session with a specialized genetic counselor to explain next steps.
النتيجة الإيجابية تعني وجود طفرة ممرضة في جين TFG تؤكد التشخيص، وتستوجب استشارة وراثية فورية وإحالة إلى طبيب أعصاب لوضع خطة علاجية شاملة وفحص أفراد الأسرة.
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