Test Price
2,800 AED✅ Home Collection Available
TCTN3 Gene Sequencing for Orofaciodigital Syndrome Type 4 in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 accredited next-generation sequencing processing.
- Collection Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Post-Test Support: Telephonic clinical guidance included for result interpretation and family counseling.
- Insurance Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
Pricing includes mandatory pre-test and post-test genetic counseling sessions with a licensed consultant medical geneticist.
Test Overview & Methodology
The TCTN3 gene sequencing test is a highly sensitive next-generation sequencing assay designed to detect pathogenic variants in the TCTN3 gene causing Orofaciodigital Syndrome Type 4, a rare ciliopathy characterized by dysmorphic facial features, polydactyly, and oral anomalies. This diagnostic assay interrogates all coding exons and flanking splice-site regions at a mean depth of coverage exceeding 100x, enabling detection of single-nucleotide variants, small insertions, and deletions.
| Feature | DNA Labs UAE | Alternative Approach |
|---|---|---|
| Technology | NGS (Illumina NovaSeq 6000) | Sanger Sequencing |
| Detection Rate | 99.9% (all coding regions +/- 20 bp) | ~95% (limited exon coverage) |
| Turnaround Time | 3 to 4 weeks | 6 to 8 weeks |
| Cost | 2,800 AED | 2,000 to 2,500 AED (estimated) |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasize that while this test provides high diagnostic yield, genetic results must be interpreted alongside clinical phenotype and family pedigree. A positive result confirms the diagnosis, but a negative result does not entirely exclude Orofaciodigital Syndrome Type 4 due to possible deep intronic variants or the involvement of other genes. Pre-test and post-test genetic counseling are essential to guide families toward informed health decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication without consulting your treating physician. Genetic testing does not replace ongoing clinical management or medication regimens.
Exclusion Criteria & Emergency Red Flags
- Patients without a clinically suspected diagnosis of Orofaciodigital Syndrome Type 4 based on dysmorphic features, polydactyly, or oral anomalies.
- Inability to provide informed consent; mandatory genetic counseling is required prior to sample collection.
- Sample collection under non-sterile conditions or from a non-validated source.
- Emergency red flags: Neonatal seizures, respiratory distress, or severe feeding difficulties in an infant with suspected Orofaciodigital Syndrome Type 4 require immediate emergency care.
Patient FAQ & Clinical Guidance
1. Is this test suitable for children and newborns?
Yes, the test is appropriate for children and neonates suspected of having Orofaciodigital Syndrome Type 4. Collection requires only a small blood sample or buccal swab, and early diagnosis enables timely intervention for associated anomalies.
2. How accurate is the TCTN3 next-generation sequencing test compared to other methods?
Our next-generation sequencing test achieves 99.9% diagnostic sensitivity, detecting nearly all known pathogenic TCTN3 variants in coding regions and splice sites. This surpasses conventional Sanger sequencing, which often misses deep intronic or copy-number changes.
3. What is the turnaround time and cost, and does insurance cover it?
Results are delivered within 3 to 4 weeks at a cost of 2,800 AED. Direct insurance billing is available through our verification team; please contact us via WhatsApp at +971 54 548 8731 to confirm your coverage. The price includes mandatory pre-test and post-test genetic counseling sessions.
4. How should I prepare for the sample collection?
No special preparation such as fasting is required. If you opt for home collection, our mobile phlebotomist will arrive at your location within the scheduled window. Please ensure a quiet, clean space for the procedure and have your Emirates ID or passport ready for verification.
5. What happens if my result is positive?
A positive result confirms the diagnosis of Orofaciodigital Syndrome Type 4. Our consultant medical geneticist will schedule a telephonic counseling session to explain the findings, discuss inheritance patterns, and coordinate referrals to pediatric specialists, cardiologists, or neurologists as needed.
UAE Regulatory & Data Privacy Adherence
- Data Protection: All patient genetic data is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Security: Electronic health records and laboratory information systems adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Patient safety protocols and informed consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory Accreditation: DNA Labs UAE operates under DHA Facility License Number 1143 and maintains ISO 9001:2015 certification for quality management.
Clinical & Logistical Metadata
| Test Name | TCTN3 Gene Sequencing for Orofaciodigital Syndrome Type 4 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole Blood or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq 6000) |
| ICD-10-CM Code | Q87.0 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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