Test Price
2,800 AED✅ Home Collection Available
SPRED1 Gene Legius Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SPRED1 لمتلازمة ليجيوس بتقنية التسلسل الجيني المتقدم (NGS) في الإمارات | ٢٨٠٠ درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy across all Emirates.
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed genetic counsellor.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview
The SPRED1 Gene Legius Syndrome Genetic Test screens the entire coding region of the SPRED1 gene using Next-Generation Sequencing to confirm a clinical diagnosis of Legius syndrome (a RASopathy distinct from Neurofibromatosis type 1). يفحص هذا الاختبار الجين الكامل لاكتشاف الطفرات المسببة لمتلازمة ليجيوس، مما يوفر تشخيصًا دقيقًا ويفرقها عن الورم العصبي الليفي.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Methodology | Full Gene NGS (Next-Generation Sequencing) with copy number variant detection | Limited Sanger sequencing of hotspot exons or targeted mutation analysis |
| Diagnostic Yield | >95% for pathogenic variants in SPRED1 | ~40-60% (only known mutations) |
| Turnaround Time | 3 to 4 Weeks (expedited available) | 4-8 Weeks |
| Accreditation | ISO 9001:2015 & DHA Facility License 9834453 | Variable; often foreign labs without UAE legal compliance |
Physician Insight & Safety Protocol
"Dr. PRABHAKAR REDDY (DHA License: 61713011) advises: This test is a powerful diagnostic tool when multiple café-au-lait macules are present without neurofibromas. Results must always be correlated with clinical findings and family history to rule out differentials such as NF1. Genetic counselling before and after testing is essential for proper interpretation."
⚠ Medication & Safety Warning
Do not discontinue prescribed medication without consulting your doctor. No special preparation is required for the blood draw, but inform the phlebotomist of all current medications.
Exclusion Criteria (Home Collection & Testing)
- Severe anemia or active bleeding disorder (physician clearance required).
- Inability to provide informed consent (minors require legal guardian consent as per CDS Law 2026).
- Unstable vital signs or acute febrile illness on the day of collection—reschedule advised.
Emergency Red Flags – Seek Immediate Medical Attention
- Sudden onset of severe headache, vision changes, or seizures.
- Unexplained rapid growth of skin lesions or new neurological symptoms.
- Chest pain, severe palpitations, or unexplained weight loss.
Patient FAQ & Clinical Guidance
1. What is the SPRED1 Gene Legius Syndrome Genetic Test, and why is it done?
This test analyzes the entire SPRED1 gene to identify disease-causing mutations responsible for Legius syndrome, a condition characterized by multiple café-au-lait spots without neurofibromas. Legius syndrome belongs to the RASopathy group and can mimic neurofibromatosis type 1 (NF1), but it typically lacks the tumor risk associated with NF1. Accurate genetic differentiation prevents unnecessary surveillance and anxiety. The NGS method ensures all coding exons and splice sites are evaluated, detecting both known and novel variants. A positive result confirms the clinical suspicion, while a negative result may warrant further evaluation for NF1 or other disorders.
يقوم هذا الاختبار بفحص كامل جين SPRED1 لاكتشاف الطفرات المسببة لمتلازمة ليجيوس، والتي تتميز ببقع قهوة بالحليب دون أورام ليفية عصبية. المتلازمة شبيهة بالورم العصبي الليفي لكنها أقل خطورة، ويساعد التحليل في تجنب المتابعة غير الضرورية.
2. How is the test performed, and what is the turnaround time in the UAE?
A simple blood sample, extracted DNA, or a single drop on an FTA card is collected by our DHA-licensed phlebotomist, with results delivered in 3 to 4 weeks after laboratory receipt. The sample undergoes Next-Generation Sequencing (NGS) at our ISO 9001:2015 certified facility in Dubai. Once the sequencing is complete, bioinformatics analysis aligns the reads to the reference genome and identifies single nucleotide variants, small insertions/deletions, and copy number changes. Every pathogenic finding is confirmed by orthogonal methods. You can book a home collection slot between 8 AM and 11 PM, and the sample is transported in a temperature-controlled cold chain directly to the lab. You will receive a secure link to your report and an optional telephonic consultation with a genetic counsellor.
تُسحب عينة دم بسيطة أو حمض نووي مستخلص، وتصدر النتائج خلال ٣ إلى ٤ أسابيع بعد وصولها إلى المختبر. يتم التحليل بتقنية التسلسل المتقدم في مختبرنا المعتمد، مع خدمة سحب منزلي من ٨ صباحًا حتى ١١ مساءً.
3. Is this test covered by insurance, and what laws protect my privacy in the UAE?
We verify direct billing eligibility with all major UAE insurers via WhatsApp at +971 54 548 8731; patient data is safeguarded under UAE PDPL and Federal Decree-Law No. 41 of 2024. All genetic information is classified as sensitive personal data and handled with the highest confidentiality. The genomic data is stored on encrypted servers compliant with UAE health data localization requirements. Your request is processed under DHA Facility License 9834453, ensuring adherence to quality and ethical standards. Minors’ testing follows the CDS Law 2026 which mandates parental consent and mandatory genetic counselling prior to sampling. You can request data deletion at any time in line with the PDPL.
نتحقق من تغطية التأمين عبر واتساب على +971 54 548 8731، وجميع البيانات محمية بموجب قانون حماية البيانات الشخصية الإماراتي والمرسوم الاتحادي رقم 41 لسنة 2024. الاختبارات الجينية تُعامل بسرية تامة وفق أعلى المعايير.
📞 Schedule Your Home Collection: +971 54 548 8731 (WhatsApp available)
🏥 DHA Facility License No.: 9834453 | ISO 9001:2015 Certified (INT/EGQ/2509DA/3139)
© 2026 DNA Labs UAE. All rights reserved. Compliant with UAE Federal Decree-Law No. 41 of 2024 (Art. 87) and PDPL.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians