Test Price
2,800 AED✅ Home Collection Available
SPG11 Gene Sequencing (NGS) Test in UAE | 2800 AED | DHA‑Licensed
Executive Summary & Core Metrics
UAE‑Trusted Diagnostic Accuracy
- 99.9% Diagnostic Sensitivity via ISO‑Certified NGS Processing.
- VIP Mobile Phlebotomy & Cold‑Chain Home Collection – available daily 8 AM–11 PM.
- Post‑Test Clinical Guidance with telephonic result interpretation.
- Direct Insurance Billing Verification via WhatsApp +971 54 548 8731.
Core Metrics at a Glance
- Price: 2,800 AED
- Turnaround Time: 10–14 business days
- Sample Types: Whole Blood, Extracted DNA, Dried Blood Spot
- Methodology: Next‑Generation Sequencing (full SPG11 coding regions)
Test Overview & Methodology
The SPG11 Gene Sequencing Test uses Next‑Generation Sequencing (NGS) to analyse all coding regions of the SPG11 gene, the primary cause of Hereditary Spastic Paraplegia Type 11 (HSP‑11). This comprehensive genetic analysis, available across the UAE with DHA‑compliant home collection, delivers definitive diagnostic information for patients experiencing progressive leg stiffness, weakness, and neurological decline.
| Feature | Our Test (SPG11 NGS) | Closest Alternative (Targeted MLPA) |
|---|---|---|
| Method | Next‑Generation Sequencing (full gene coverage) | Multiplex Ligation‑dependent Probe Amplification (deletions/duplications only) |
| Detection Rate | >99% of pathogenic variants | ~70% (misses point mutations) |
| Turnaround Time | 10–14 business days | 4–6 weeks |
| Price (AED) | 2,800 | 2,500–3,200 (often with reflex tests) |
| Sample Options | Whole Blood, Extracted DNA, Dried Blood Spot | Whole Blood only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA Registration ID: 9294403) notes: “The SPG11 gene test provides essential diagnostic clarity for hereditary spastic paraplegia type 11. A positive mutation must be evaluated alongside clinical presentation, family history, and imaging. This NGS-based analysis offers superior sensitivity for point mutations and small indels, guiding multidisciplinary management and genetic counselling for at-risk relatives.”
Critical Advisory: Medication Safety
⚠️ Do Not Discontinue Prescribed Medications
Genetic test results must never be used to independently alter medication regimens. Always consult your treating physician before making any changes to your therapy.
Patient Safety & Exclusion Criteria
- Exclusion: Acute febrile illness, severe coagulopathy, or ongoing anticoagulation without medical clearance.
- Post‑Collection Caution: Keep pressure dressing; contact nurse if bleeding persists.
- ER Red Flags (seek immediate care): Sudden severe neurological deterioration, respiratory difficulty, loss of consciousness, or signs of raised intracranial pressure after sample collection.
Patient FAQ & Clinical Guidance
1. What is the SPG11 gene test, and how does it diagnose hereditary spastic paraplegia?
The SPG11 gene test uses Next‑Generation Sequencing to analyse all coding regions of the SPG11 gene, detecting pathogenic mutations that cause HSP type 11, a progressive neurological disorder characterised by leg stiffness and gait dysfunction. It is the gold standard for confirming the diagnosis.
2. How is the sample collected, and is home collection available in the UAE?
We offer a DHA‑licensed VIP mobile phlebotomy service across all emirates. A certified nurse collects a blood sample, extracted DNA, or dried blood spot using painless techniques, with temperature‑controlled cold‑chain transport to our ISO‑accredited laboratory. Home collection is available daily from 8 AM to 11 PM.
3. What does a positive result mean for my treatment and family?
A positive result confirms the genetic diagnosis, enabling targeted management, physiotherapy, and genetic counselling for at‑risk relatives, while ruling out other neurological conditions. It also allows for family cascade testing and informed reproductive planning.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Data Protection: Fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of ICT in Health Fields.
- Medical Liability: All procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring patient consent and safety.
- Facility Credentials: DHA Facility License No. 1143, ISO 9001:2015 Certified (INT/EGQ/2509DA/3139).
- Confidentiality: All genetic data is handled with strict confidentiality. Telephonic clinical guidance is provided post‑result, but definitive medical decisions must be made by a licensed practitioner.
Clinical & Logistical Metadata
| Test Name | SPG11 Gene Sequencing (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 10–14 business days |
| Sample Type / Matrix | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region coverage |
| ICD-10-CM Code | G11.4 (Hereditary spastic paraplegia) |
| LOINC Code | 40825-5 (Hereditary spastic paraplegia gene mutation detection) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians