Test Price
2,800 AED✅ Home Collection Available
SLC30A10 Gene Analysis (Hypermanganesemia with Dystonia, Polycythemia & Cirrhosis) – Genetic Test in UAE | AED 2,800 | DHA Guidelines
Executive Summary & Core Metrics
This comprehensive NGS-based genetic test delivers 99.9% diagnostic accuracy for the detection of pathogenic SLC30A10 variants associated with hypermanganesemia, dystonia, polycythemia, and cirrhosis. Our ISO 9001:2015 certified laboratory ensures rigorous quality control. For your convenience, we offer VIP Mobile Phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all seven emirates. Each test includes a post-result telephone consultation with a genetic specialist for clinical interpretation. Direct insurance verification is available via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The SLC30A10 gene analysis utilizes Next-Generation Sequencing (NGS) to identify disease-causing mutations across the entire gene, including deep intronic regions. This approach is superior to traditional Sanger sequencing for detecting novel and rare variants. Results are interpreted in accordance with ACMG guidelines, providing a comprehensive report that includes variant classification and genotype-phenotype correlation.
| Feature | Our NGS Gene Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Variant Coverage | Full gene with deep intronic regions – detects novel & rare variants | Limited to known hot‑spot exons; may miss deep intronic mutations |
| Turnaround Time | 3 – 4 weeks (optimised laboratory workflow) | 4 – 6 weeks; often delayed due to sequential exon walk |
| Clinical Utility | Comprehensive report with variant classification per ACMG guidelines | Basic mutation detection only; limited genotype‑phenotype correlation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA ID: 9294403) notes: “Every genetic finding must be correlated with biochemical manganese levels and the patient’s full clinical picture; this test is highly sensitive but never a substitute for a thorough history and physical examination. I strongly recommend pre- and post-test genetic counselling to ensure the family understands the implications of a positive result. Always interpret this result within the context of your personal and family medical background.”
⚠ Important Advisory
Do not discontinue any prescribed medication or start new supplements (especially manganese or chelation agents) based solely on this genetic result. Always consult your treating physician.
Exclusion Criteria & Emergency Red Flags
- Inability to provide the required sample (blood/FTA card) due to severe anaemia or medical instability.
- Recent blood transfusion within 2 weeks (may cause donor DNA interference).
- Acute dystonic crisis with respiratory compromise – seek immediate emergency care; do not delay for test collection.
- Signs of acute liver failure (jaundice, confusion, coagulopathy) – warrant urgent hospital evaluation.
- Severe polycythemia (haematocrit >60%) with neurological symptoms – proceed to emergency phlebotomy.
Patient FAQ & Clinical Guidance
1. What does the SLC30A10 genetic test detect?
Answer: The SLC30A10 NGS panel identifies disease‑causing mutations across the entire gene, confirming hypermanganesemia with dystonia, polycythemia, and cirrhosis. It precisely characterises pathogenic variants, enabling early intervention such as chelation therapy or dietary control to halt disease progression.
2. Why does the test take 3–4 weeks for results?
Answer: The extended turnaround time ensures rigorous library preparation, high‑depth sequencing, and expert variant interpretation per international ACMG standards. We perform dual confirmatory reads and a clinical correlation step, which safeguards against false‑positive calls and missed variants.
3. Is home blood collection available across the UAE?
Answer: Yes, our ISO‑certified mobile phlebotomy team serves all seven emirates daily between 8 AM and 11 PM. We handle whole blood, extracted DNA, or a single drop on an FTA card—whichever is most convenient for you.
UAE Regulatory & Data Privacy Adherence
This service is provided in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted and stored locally on UAE-based servers. Patient consent is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is licensed under DHA Facility License Number: 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE).
Clinical & Logistical Metadata
| Test Name | SLC30A10 Gene Analysis (Hypermanganesemia with Dystonia, Polycythemia & Cirrhosis) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene sequencing with deep intronic coverage |
| ICD-10-CM Code | E83.89 |
| LOINC Code | 82940-5 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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