Test Price
2,800 AED✅ Home Collection Available
SLC26A1 Gene Genetic Test | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
This advanced genetic analysis provides precise detection of SLC26A1 gene pathogenic variants associated with renal dysfunction and calcium oxalate nephrolithiasis, achieving 99.9% diagnostic sensitivity via Next Generation Sequencing (NGS). The test empowers clinicians to identify at-risk individuals, guide preventive nephrology strategies, and inform family screening protocols within a 3-4 week turnaround.
- Accuracy Guarantee: 99.9% Analytical Sensitivity via ISO 15189 Accredited Processing with full CNV detection.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Genetic Counseling and result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SLC26A1 gene encodes a sulfate-anion transporter essential for renal tubular handling of oxalate. Pathogenic variants impair sulfate reabsorption, leading to hyperoxaluria and recurrent calcium oxalate stone formation. This targeted NGS assay interrogates all coding exons and flanking intronic regions, delivering comprehensive variant identification for clinical decision-making.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% analytical sensitivity, full gene coverage including deep intronic regions | ~99% per exon, may miss deep intronic variants & CNVs |
| Method | Next Generation Sequencing (NGS) with copy number variant analysis | Bidirectional Sanger sequencing |
| Turnaround | 3–4 weeks | 4–6 weeks (fragmented exon-by-exon analysis) |
Physician Insight & Safety Protocols
“Genetic predisposition testing for SLC26A1 variants provides a powerful preventive lens for patients with a family history of nephrolithiasis. Identifying a pathogenic variant does not guarantee stone formation, but it enables proactive dietary modifications, hydration protocols, and targeted metabolic monitoring. Always correlate genetic findings with clinical presentation and family pedigree before implementing management changes.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue, alter, or adjust any prescribed medication—including diuretics, allopurinol, or potassium citrate—without direct consultation with your managing nephrologist or primary care physician. Genetic test results complement, not replace, your current treatment regimen.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: This test is intended for elective genetic risk assessment in stable patients with clinical suspicion or positive family history of nephrolithiasis. Not indicated for acute renal failure evaluation, pediatric patients without guardian consent, or individuals currently undergoing active lithotripsy without prior nephrology clearance.
- ER Red Flags: Seek immediate emergency care if you experience sudden severe flank or groin pain, gross hematuria, fever with chills suggestive of pyelonephritis, anuria, or signs of septic shock. These symptoms may indicate obstructive uropathy, acute stone impaction, or urinary tract infection requiring urgent intervention.
Patient FAQ & Clinical Guidance
1. What is the SLC26A1 gene and why is it tested?
The SLC26A1 gene provides instructions for a sulfate transporter expressed in the renal proximal tubule. This transporter is critical for oxalate homeostasis; pathogenic variants impair sulfate reabsorption, elevate urinary oxalate levels, and dramatically increase the risk of recurrent calcium oxalate kidney stones. Testing identifies at-risk individuals before stone formation begins, enabling early dietary intervention and metabolic surveillance.
2. How is the test performed and what is the turnaround time?
A simple peripheral whole blood sample or buccal DNA swab is collected by our trained phlebotomist during a temperature-controlled home visit. DNA is extracted and sequenced on Illumina platforms using a targeted NGS panel covering all SLC26A1 coding exons. Bioinformatics analysis identifies single nucleotide variants, small insertions/deletions, and copy number changes. Results are delivered within 3–4 weeks with a detailed clinical report.
3. Can I receive genetic counseling after the result?
Yes. Every test includes a telephonic post-test consultation with our Consultant Medical Geneticist, Lina Osama Zaki Quteineh, who will explain your variant findings in the context of your personal medical history, family pedigree, and stone prevention strategies. A referral to a nephrologist can be arranged for comprehensive metabolic management.
4. Does my UAE insurance cover this genetic test?
Many UAE health insurance plans provide coverage for medically indicated genetic testing, particularly when there is a documented family history of nephrolithiasis or renal dysfunction. Our billing team verifies your coverage directly with your insurer and assists with pre-authorization documentation. Contact +971 54 548 8731 via WhatsApp for a personalized benefits check.
UAE Regulatory & Data Privacy Adherence
Your Data Is Protected Under UAE Federal Law
DNA Labs UAE complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) governing the collection, processing, and storage of your genetic information. All clinical data handling also adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields ensuring secure electronic health record management. Patient safety and informed consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Your genetic data is encrypted, access-controlled, and never shared with third parties without your explicit written consent. You retain the right to access, rectify, and request deletion of your data in accordance with PDPL provisions.
Clinical & Logistical Metadata
| Test Name | SLC26A1 Gene Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal DNA Swab |
| Methodology Used | Next Generation Sequencing (NGS) with CNV Analysis |
| ICD-10-CM Code | N20.0 (Calcium oxalate nephrolithiasis) |
| LOINC Code | 82305-9 (SLC26A1 gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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