Test Price
2,800 AED✅ Home Collection Available
RETREG1 Gene HSAN2B Genetic Test in UAE | 2800 AED | DHA-Certified Molecular Diagnosis
Executive Summary & Core Metrics
- Diagnostic Accuracy: >99.9% sensitivity for single nucleotide variants, indels, and copy number variants via ISO-accredited next-generation sequencing.
- VIP Home Collection: Hospital-grade mobile phlebotomy with ISO-certified cold-chain logistics, available daily from 8 AM to 11 PM across all UAE emirates.
- Post-Test Clinical Guidance: Complimentary telephonic consultation with a DHA-licensed medical geneticist to interpret your results in the context of your family history and clinical presentation.
- Insurance Verification: Direct insurance coverage checks via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The RETREG1 Gene NGS test is a highly specialized single-gene sequencing analysis that detects pathogenic variants associated with Hereditary Sensory and Autonomic Neuropathy Type 2B (HSAN2B). It offers comprehensive coverage of the RETREG1 gene using Next-Generation Sequencing, providing definitive molecular diagnosis for patients with sensory neuropathy, autonomic dysfunction, and familial risk assessment.
| Feature | Our Test (DHA-Certified) | Closest Alternative |
|---|---|---|
| Methodology | NGS (Illumina NovaSeq) – full gene coverage, deep intronic regions, CNV detection | Sanger sequencing – limited to selected exons, may miss large deletions |
| Diagnostic Sensitivity | >99.9% for SNVs, indels, and copy number variants | ~90% for point mutations; low sensitivity for CNVs |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Price | 2,800 AED | ~3,500 AED |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I see firsthand how a molecular diagnosis transforms care for families affected by hereditary neuropathies. This test offers precise identification of RETREG1 mutations and enables cascade screening for at-risk relatives. Please keep in mind that genetic results must be integrated with a complete neurological exam and detailed family pedigree to guide clinical decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
If you are currently taking prescribed medications for neuropathy, autonomic dysfunction, or pain management, continue your regimen as directed by your treating physician. This genetic test does not replace ongoing clinical monitoring or medication adjustments under medical supervision.
Exclusion Criteria & Red Flags
- Not suitable for acute neurological emergencies (sudden paralysis, respiratory distress, acute stroke) – seek immediate emergency care at the nearest hospital.
- Not indicated as a standalone screening for asymptomatic minors without a known familial mutation and pre-test genetic counselling.
- If you experience rapidly worsening symptoms such as unsteady gait, severe burning pain, palpitations, or syncope, proceed to the nearest emergency room without delay. Do not wait for genetic test results.
- A comprehensive clinical history and verified family pedigree must accompany the test request; a mandatory pre-test genetic counselling session is required to ensure accurate interpretation.
Patient FAQ & Clinical Guidance
1. What is the RETREG1 gene and how does it relate to HSAN2B?
The RETREG1 gene provides instructions for a protein critical to sensory and autonomic nerve maintenance; mutations in this gene cause HSAN2B, a rare hereditary neuropathy characterised by progressive loss of pain and temperature sensation, recurrent painless injuries, and autonomic instability. Symptoms often emerge in childhood or adolescence. A positive molecular result pinpoints the genetic aetiology and enables targeted clinical management and family counselling.
2. How is the sample collected and is home collection available in the UAE?
Sample collection involves a standard peripheral whole blood draw. We offer VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection across all UAE emirates, available daily from 8 AM to 11 PM. A DHA-licensed phlebotomist visits your residence, collects a small volume of whole blood, and transports it under strict temperature control to our molecular genetics laboratory. This ensures specimen integrity and full compliance with UAE healthcare regulations.
3. What do the results mean and how long do they take?
Results are delivered within 3 to 4 weeks in a comprehensive report identifying any pathogenic or likely pathogenic variants. A post-test telephonic clinical guidance session with a consultant medical geneticist is included to explain the implications fully. A positive result confirms the genetic diagnosis and enables cascade testing of at-risk family members. A negative result or variant of uncertain significance may require further neurological investigation and correlation with your full clinical picture. All reports are interpreted in accordance with DHA molecular testing standards and international ACMG guidelines.
4. Who should consider taking this genetic test?
This test is appropriate for individuals with clinical features suggestive of hereditary sensory and autonomic neuropathy, including unexplained burning or shooting pain, recurrent foot ulcers, painless fractures, impaired temperature sensation, orthostatic hypotension, or gastrointestinal dysmotility. It is also indicated for asymptomatic relatives of a confirmed HSAN2B patient who wish to understand their carrier status and reproductive risks. Pre-test genetic counselling is mandatory for all test candidates.
UAE Regulatory & Data Privacy Adherence
All services are delivered under the regulatory oversight of the Dubai Health Authority (DHA Facility License No. 1143). Our laboratory practices comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the lawful collection, processing, and storage of your personal health information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating the secure handling of electronic health records and telemedicine consultations.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – ensuring patient safety, informed consent, and professional accountability throughout the testing pathway.
DNA Labs UAE is ISO 9001:2015 certified (Cert. No. INT/EGQ/2509DA/3139), reflecting our commitment to quality management and continuous improvement in molecular diagnostic services.
Clinical & Logistical Metadata
| Parameter | Details |
|---|---|
| Test Name | RETREG1 Gene HSAN2B Genetic Test (NGS Single-Gene Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) – full gene coverage including deep intronic regions and CNV analysis |
| ICD-10-CM Code | G60.8 – Other hereditary neuropathies |
| LOINC Code | 82159-7 – RETREG1 gene targeted mutation analysis in Blood or Tissue by Sequencing |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE – Corporate Lab Branding) |
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