Test Price
2,800 AED✅ Home Collection Available
PRDM12 Gene HSAN8 Genetic Test in UAE – 2,800 AED – DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity through ISO-accredited NGS processing for complete PRDM12 coding region analysis.
- Premium Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM–11 PM.
- Clinical Guidance: Post-test telephone consultation with a consultant medical geneticist for result interpretation and counseling.
- Insurance Verification: Direct WhatsApp check at +971 54 548 8731.
Test Overview & Methodology
The PRDM12 gene HSAN8 genetic test employs next‑generation sequencing (NGS) to analyze the entire coding region and splice sites of the PRDM12 gene. This provides definitive molecular diagnosis of hereditary sensory and autonomic neuropathy type 8 (HSAN8), a rare autosomal recessive disorder characterized by congenital insensitivity to pain and autonomic dysfunction.
| Feature | Our Test: PRDM12 Full Gene NGS | Closest Alternative: Targeted Mutation Panel |
|---|---|---|
| Precision | Comprehensive exon and splice‑site coverage; detects novel and private variants | Limited to known mutations; may miss rare variants |
| Methodology | Next‑Generation Sequencing (NGS) with high‑depth bioinformatic analysis | Sanger sequencing or targeted genotyping |
| Turnaround Time | 3 to 4 weeks | 2 to 4 weeks |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I recognize the profound impact a genetic diagnosis can have on a family. The PRDM12 test offers molecular confirmation that clarifies the underlying cause of HSAN8, guiding symptom management and reproductive planning. However, results must always be interpreted alongside a comprehensive clinical evaluation. A positive result identifies the genetic cause but not a cure; a negative result does not exclude other neuropathies—ongoing neurology follow‑up is essential."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403
⚠️ Safety Advisory & Exclusion Criteria
Do not discontinue any prescribed medication without consulting your physician. This genetic test does not replace clinical management of neurological symptoms.
Exclusion Criteria
- Inability to provide informed consent (minors require legal guardian consent per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Severe coagulopathy or active bleeding disorder that precludes blood draw (alternate sample types may be discussed).
- Acute febrile illness or systemic infection at the time of collection (reschedule after recovery).
Emergency Red Flags
- Autonomic crisis: unexplained bradycardia, hypotension, or hyperthermia — seek immediate medical attention.
- Signs of severe infection (redness, swelling, pus) in an insensate limb — urgent care required to prevent sepsis.
- Acute corneal ulceration with pain (despite sensory loss, referred pain may occur) — emergency ophthalmology assessment.
Patient FAQ & Clinical Guidance
1. What is the PRDM12 gene and HSAN8?
The PRDM12 genetic test detects mutations in the gene responsible for hereditary sensory and autonomic neuropathy type 8 (HSAN8), a rare autosomal recessive disorder that impairs pain perception and autonomic functions such as sweating and blood pressure regulation. Identifying a PRDM12 mutation confirms the diagnosis and enables targeted management and genetic counseling.
2. How is the test performed and what sample is required?
A whole blood sample, extracted DNA, or dried blood spot on an FTA card is collected by a certified phlebotomist during a home visit, then shipped under cold‑chain to our ISO‑accredited laboratory. Fasting is not required.
3. What should I expect after receiving a positive result?
A positive result indicates you carry disease‑causing variants in both copies of the PRDM12 gene, confirming HSAN8. You should immediately undergo a comprehensive clinical evaluation and genetic counseling to discuss symptom management, family planning, and long‑term surveillance.
UAE Regulatory & Data Privacy Adherence
- Data Protection: All patient data is handled in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on the Use of ICT in Health Fields.
- Ethical Consent: Testing follows Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring fully informed consent, especially for minors.
- Quality Certification: Laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) for genetic testing services.
Clinical & Logistical Metadata
| Test Name | PRDM12 Gene HSAN8 Full Gene Sequencing (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or dried blood spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene sequencing |
| ICD‑10‑CM Code | G60.8, G90.8 |
| LOINC Code | 94209-3 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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