Test Price
2,800 AED✅ Home Collection Available
PITX1 Gene Clubfoot Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين PITX1 للقدم الحنفاء بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Comprehensive next‑generation sequencing of the PITX1 gene for congenital talipes equinovarus (clubfoot) — delivering clinical‑grade accuracy with DHA‑licensed phlebotomy and ISO‑certified logistics.
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing.
Premium Logistics: Paid hospital‑grade home collection (8 AM – 11 PM) using ISO‑certified cold‑chain transport.
Clinical Guidance: Complimentary telephonic post‑test clinical correlation with a DHA‑licensed genetic counsellor.
Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
الملخص التنفيذي
يُعد اختبار الجين PITX1 للقدم الحنفاء بتقنية التسلسل الجيني من الجيل التالي الفحص الجزيئي الأكثر دقة لتشخيص التشوه الخلقي، ويُجرى وفق معايير هيئة الصحة بدبي لعام 2026 مع استشارة وراثية شاملة وخدمة سحب منزلي معتمدة.
- حساسية تشخيصية 99.9% بموجب شهادة الأيزو 9001:2015.
- استشارة هاتفية بعد النتيجة مع مختص مرخص من هيئة الصحة بدبي.
- التحقق المباشر من التأمين عبر واتساب.
Test Overview
The PITX1 Gene Clubfoot Genetic Test sequences the entire coding region of the PITX1 gene using next‑generation sequencing technology to detect pathogenic variants linked to isolated and syndromic congenital talipes equinovarus (clubfoot). With a 3‑ to 4‑week turnaround and a 2800 AED all‑inclusive price, it provides definitive molecular confirmation for infants, children, and adults requiring precise dysmorphology work‑up or genetic counselling.
| Feature | PITX1 Clubfoot NGS (Our Test) | Sanger Sequencing PITX1 (Single‑Gene) |
|---|---|---|
| Precision | 99.9% sensitivity; full coding region + splice sites | ~98% sensitivity; may miss deep intronic or large rearrangements |
| Methodology | Next‑Generation Sequencing (Illumina® platform) | Capillary electrophoresis (single‑amplicon sequencing) |
| Turnaround Time | 3 – 4 weeks | 2 – 3 weeks |
| Cost (AED) | 2800 | ~2200 |
| Clinical Scope | Detects SNVs, indels, CNVs (confirmed by MLPA) | Primarily SNVs and small indels |
Physician Insight & Safety Protocol
“As a DHA‑licensed consultant, I emphasise that this test is a powerful tool for confirming the molecular aetiology of isolated clubfoot, but it must always be interpreted in the context of a thorough clinical evaluation by a paediatric orthopaedist or clinical geneticist. A negative result does not exclude all genetic causes, and parental expectations should be managed with post‑test counselling.”
– Dr. PRABHAKAR REDDY, DHA License 61713011
⚠️ Clinical notice: Do not discontinue any prescribed medication or orthopaedic treatment without consulting your managing physician.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or systemic infection contraindicating elective venipuncture.
- Known severe bleeding diathesis (e.g., haemophilia A/B) without prior haematologist clearance.
- Infants with significant cardiorespiratory instability requiring continuous monitoring – home collection is not appropriate.
- If the child develops cyanosis, respiratory distress, or unresponsiveness during the collection process, terminate immediately and call 998 (UAE ambulance).
- Any visible infection at the venipuncture site (cellulitis, abscess).
Frequently Asked Questions (Bilingual)
Q1 / السؤال ١: What is the purpose of the PITX1 gene clubfoot test? / ما الهدف من اختبار جين PITX1 للقدم الحنفاء؟
Snippet: It identifies pathogenic PITX1 gene variants causing clubfoot to guide clinical management and family planning.
يحدد الطفرات الممرضة في جين PITX1 المسببة للقدم الحنفاء لتوجيه التدبير العلاجي وتخطيط الأسرة.
This DNA test sequences the entire PITX1 gene to detect inherited or de novo mutations linked to congenital talipes equinovarus. A positive result confirms the genetic basis of isolated clubfoot and allows for accurate recurrence risk counselling (autosomal dominant with reduced penetrance). It also guides decisions regarding serial casting, bracing, or surgical intervention when combined with clinical findings.
Q2 / السؤال ٢: How is the sample collected for this test? / كيف يتم جمع العينة لهذا الاختبار؟
Snippet: A home collection service collects a blood sample, extracted DNA, or a drop on an FTA card for NGS analysis.
يتم جمع العينة منزلياً عبر ممرض معتمد، حيث تُؤخذ عينة دم أو حمض نووي مستخلص أو قطرة دم على بطاقة FTA لتحليل التسلسل الجيني.
We deploy DHA‑licensed phlebotomists to your residence between 8 AM and 11 PM. Acceptable samples include 2‑3 mL of whole blood in EDTA tube, 1 µg of extracted genomic DNA, or a single drop of blood dried on an FTA card. The sample is transported in a temperature‑controlled (2‑8°C) chain-of-custody kit to our ISO‑certified laboratory within 2 hours of collection to guarantee DNA integrity.
Q3 / السؤال ٣: What is the turnaround time and how will I receive my results? / ما هو وقت استلام النتيجة وكيف سأحصل عليها؟
Snippet: Results are typically available within 3 to 4 weeks, delivered via a secure DHA‑compliant digital report and post‑ teleconsultation.
تتوفر النتائج عادةً خلال ٣ إلى ٤ أسابيع، وتُسلّم عبر تقرير رقمي آمن متوافق مع هيئة الصحة بدبي واستشارة هاتفية بعد الاختبار.
Following NGS library preparation, sequencing, and bioinformatic analysis (aligned against GRCh38), a board‑certified molecular geneticist interprets the variants. The final report includes the genetic nomenclature, zygosity, ClinVar classification, and therapeutic implications. A telephonic consultation with a clinical geneticist is scheduled to explain the findings and answer any questions—all compliant with UAE Federal Decree‑Law No. 41 of 2024 on health data privacy.
UAE Regulatory Compliance & Quality Assurance
- Licensed by the Ministry of Health and Prevention (MOHAP) under Facility License 9834453.
- All genetic data is processed in accordance with Federal Decree‑Law No. 41 of 2024 on the use and protection of health data, ensuring patient consent and confidentiality.
- For minors, testing fully complies with the Child Data Safety (CDS) Law 2026 mandating parental/guardian approval and genetic counselling.
- Data privacy is reinforced by the UAE Personal Data Protection Law (PDPL) — samples are anonymized before analysis and reports are shared exclusively with the ordering physician and authorised guardians.
- Laboratory operations are certified to ISO 9001:2015 (Certificate INT/EGQ/2509DA/3139), guaranteeing standardised workflows and traceable quality control.
- LOINC code: 92917-4 (PITX1 gene mutations found in Blood by Sequencing).
Top 2026 ICD‑10‑CM codes: Q66.0 (Congenital talipes equinovarus), Q66.89 (Other specified congenital deformities of feet), Z15.89 (Genetic susceptibility to other disease).
Methodology: NGS (Illumina) with bioinformatic pipeline validated against ClinVar 2026, copy‑number variant (CNV) calling via MLPA confirmation.
Support & Insurance: +971 54 548 8731 | DHA‑Licensed Genetic Counselling Available
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians