Test Price
2,800 AED✅ Home Collection Available
PAX9 Genetic Test for Tooth Agenesis (Oligodontia) in UAE | 2,800 AED | DHA Licensed Molecular Diagnosis
Executive Summary & Core Metrics
Molecular Confirmation for Selective Tooth Agenesis Type 3 (STHAG3)
The PAX9 genetic test provides definitive molecular confirmation of selective tooth agenesis type 3 through high-fidelity next-generation sequencing. Early identification of pathogenic variants enables timely orthodontic and prosthodontic intervention, directly improving long-term oral health outcomes and quality of life.
- Diagnostic Sensitivity: >99.9% analytical sensitivity validated under ISO 9001:2015 accredited protocols for all PAX9 coding and regulatory regions.
- Collection Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – available daily from 8 AM to 11 PM. Whole blood or FTA card accepted.
- Post-Test Guidance: Telephonic clinical interpretation provided by a Consultant Medical Geneticist following result delivery.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
PAX9 gene sequencing utilises next-generation sequencing (NGS) to identify disease-causing mutations in the PAX9 gene, which encodes a transcription factor critical for tooth development. Pathogenic variants in PAX9 are associated with selective tooth agenesis type 3 (STHAG3), a condition characterised by congenital absence of permanent teeth, most commonly affecting premolars and molars. This targeted analysis avoids the incidental findings common to broader genomic panels while delivering comprehensive coverage of all exonic, intronic, and regulatory regions.
| Feature | DNA Labs UAE – PAX9 NGS Panel | Standard Genetic Testing |
|---|---|---|
| Precision | >99.9% analytical sensitivity capturing coding, deep intronic, and regulatory variants | May miss non-coding or splice-site alterations with conventional Sanger sequencing |
| Methodology | Next Generation Sequencing (NGS) – full PAX9 gene coverage with 50x minimum depth | Sanger sequencing limited to coding exons or multi-gene panels without dedicated PAX9 depth |
| Turnaround Time | 3–4 weeks from sample receipt to final clinical report | 4–8 weeks for equivalent single-gene or small panel analysis |
| Scope | PAX9-focused with minimal incidental findings; results clearly actionable | Broader panels increase likelihood of uncertain incidental findings requiring further workup |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics | DHA Registration ID: 9294403
“A confirmed PAX9 pathogenic variant offers a clear molecular anchor for early orthodontic and prosthodontic intervention, significantly improving a child’s functional and aesthetic outcome. However, a negative result does not rule out other genetic or environmental causes; clinical correlation with dental examination and family pedigree remains indispensable. I always advocate for multidisciplinary discussion—integrating genetics, paediatric dentistry, and orthodontics—to tailor the most effective management plan for each patient.”
Advisory – Medication & Clinical Precautions
Medication Stability Notice
Maintain all current prescribed therapies unless explicitly advised otherwise by your treating physician. Abrupt discontinuation of medications—particularly anticoagulants or immunosuppressants—may pose serious health risks. Discuss any changes with your doctor before sample collection.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to provide informed consent, documented severe bleeding diathesis, or blood product transfusion within the preceding 24 hours.
- Red Flags – Seek Immediate Dental/Medical Attention: Unexplained tooth mobility, persistent jaw pain, fever of dental origin, facial swelling, or any sign of systemic infection.
- Pre-Test Requirement: A mandatory genetic counselling session must be completed before sample collection to construct a three-generation pedigree and confirm clinical indication.
Patient FAQ & Clinical Guidance
1. What is the PAX9 genetic test for tooth agenesis?
This targeted NGS test analyses the PAX9 gene for mutations that cause selective tooth agenesis type 3 (STHAG3). The result confirms whether a genetic variant is responsible for missing permanent teeth, enabling early prosthetic and orthodontic planning.
2. Who should consider this test?
Individuals with unexplained absence of permanent teeth—particularly premolars and molars—and a family history of oligodontia are ideal candidates. The test is also appropriate for children with delayed dental eruption patterns suggestive of a genetic aetiology.
3. How is the sample collected?
A certified phlebotomist collects a standard venous blood sample (2–3 mL in an EDTA tube) or a single drop of blood on an FTA card during a scheduled home visit. The collection follows ISO-compliant cold-chain protocols and is available daily from 8 AM to 11 PM.
4. What is the turnaround time for results?
Results are typically available within 3–4 weeks from the date the sample is received at the laboratory. A telephonic post-test consultation with a Consultant Medical Geneticist is included to review findings and discuss next steps.
5. Does a negative result rule out tooth agenesis?
No. A negative PAX9 result does not exclude other genetic causes (e.g., MSX1, WNT10A, EDA mutations) or non-genetic factors. Clinical correlation with a dental examination, family history, and possible broader genetic testing may be recommended by your specialist.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights – Fully Compliant with UAE Law
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic and personal data are processed under strict lawful basis, consent management, and data minimisation principles.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and genomic data transmission meet mandated security and interoperability standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Patient safety and informed consent protocols are audited regularly to ensure clinical governance and legal compliance.
- DHA Facility License 1143: All testing is performed at our Dubai Healthcare City laboratory under the direct oversight of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | PAX9 Genetic Test for Tooth Agenesis (Oligodontia) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next Generation Sequencing (NGS) – Full PAX9 Gene Coverage (coding, intronic, regulatory regions) |
| ICD-10-CM Code | K00.0 |
| LOINC Code | 94222-1 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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