Test Price
2,800 AED✅ Home Collection Available
MYH2 Gene Inclusion Body Myopathy Genetic Test in UAE
Executive Summary & Core Metrics
Diagnostic accuracy: 99.9% sensitivity via ISO 9001:2015-accredited processing. Premium hospital-grade mobile phlebotomy with temperature-controlled cold-chain home collection. Post-test telephonic clinical guidance for result interpretation. Direct insurance billing verification via WhatsApp: +971545488731. Fully compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability.
Test Overview & Methodology
This advanced next-generation sequencing (NGS) test comprehensively analyzes the entire coding region of the MYH2 gene to identify pathogenic variants responsible for hereditary inclusion body myopathy. The single-gene NGS approach provides a definitive molecular diagnosis with class-leading accuracy, guiding personalized neurology management, genetic counseling, and family risk assessment.
| Feature | Our NGS Test (MYH2 Single-Gene) | Closest Alternative (Conventional Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – covers all exons, intron-exon boundaries, and known deep intronic variants | Sanger sequencing – typically performed exon-by-exon, limited to pre-selected regions |
| Variant Coverage | >99% of the coding region plus splice sites; simultaneous detection of single nucleotide variants, small indels, and copy number changes | Targeted analysis of specific exons; deletions/duplications rarely detected without additional MLPA assay |
| Turnaround Time | 3 to 4 weeks | 6 to 8 weeks (often requiring multiple rounds) |
| Cost in UAE | 2,800 AED (all-inclusive) | 3,500–4,200 AED (depending on number of exons) |
| Clinical Confidence | Gold-standard resolution – ideal for diagnostic confirmation and family screening | Lower diagnostic yield; may miss complex or novel mutations |
Physician Insight & Safety Protocols
“A positive MYH2 mutation can explain a patient’s progressive muscle weakness and guide targeted surveillance, but results must always be correlated with clinical phenotype and electromyography findings. Your neurologist or clinical geneticist will use this report to craft a multidisciplinary care plan that respects your unique health journey. I remind every patient that genetic information is only one piece of the diagnostic puzzle.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Medication Warning: Do not discontinue any prescribed medication, especially immunosuppressants or myopathy-related drugs, without explicit guidance from your treating physician. Abrupt cessation may worsen muscle function.
Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not suitable as a stand-alone screen in asymptomatic minors without parental consent and genetic counseling as per UAE regulatory requirements.
- Exclusion: Samples compromised by recent blood transfusion (within 14 days) or allogeneic bone marrow transplant may yield inaccurate germline results.
- ER Red Flag: Sudden worsening of muscle weakness, difficulty swallowing, or respiratory distress warrants immediate emergency evaluation – do not wait for genetic results.
- ER Red Flag: New-onset cardiac symptoms (palpitations, syncope) in a patient with known MYH2-related myopathy may indicate cardiac involvement requiring urgent cardiology consult.
Patient FAQ & Clinical Guidance
1. What exactly does the MYH2 Genetic Test detect and how accurate is it?
It sequences all coding exons of the MYH2 gene with 99.9% diagnostic sensitivity, identifying single-nucleotide variants, small insertions/deletions, and large copy-number imbalances that cause autosomal dominant inclusion body myopathy.
2. How should I prepare for the blood collection, and is an FTA card acceptable?
No fasting is required; a 2–3 mL whole blood sample (EDTA tube) is standard, but a single drop of blood on an FTA card or previously extracted DNA can also be submitted, provided it meets ISO 9001:2015 cold-chain requirements during transport.
3. How long will it take to receive my results, and who interprets them?
Results are typically available within 3 to 4 weeks from sample receipt, and a dedicated post-telephonic consultation with a clinical geneticist or neurologist is included to explain the findings and implications for your family.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE ensures full compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed and stored under strict confidentiality controls, accessible only to authorized clinical personnel. Patient consent is obtained prior to testing in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MYH2 Gene Inclusion Body Myopathy Genetic Test (NGS) |
| Price (AED) | 2,800 AED (all-inclusive) |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube), FTA card, or extracted DNA. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region, intron-exon boundaries, and known deep intronic variants |
| ICD-10-CM Code | G71.2 (Other myopathies) |
| LOINC Code | 81247-9 (MYH2 gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Laboratory: DNA Labs UAE | Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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