Test Price
2,800 AEDโ Home Collection Available
MYBPC1 Gene Sequencing for Distal Arthrogryposis Type 1B (NGS) Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing at DNA Labs UAE.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by Consultant Medical Genetics.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test analyzes the entire coding region of the MYBPC1 gene to detect pathogenic variants causing distal arthrogryposis type 1B, a rare congenital contracture disorder. The test is performed at our DHA-licensed laboratory using validated methods with >99% base coverage at >20x depth.
Test Comparison: Our NGS vs. Closest Alternative
| Feature | Our Test (NGS) | Sanger Sequencing (Alternative) |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) | Sanger sequencing |
| Coverage | Full MYBPC1 gene (>99% bases covered at >20x) | Targeted coding exons only |
| Sensitivity | 99.9% for SNVs, small indels, and copy number variants* | ~99% for point mutations, limited large deletion detection |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Price | 2800 AED | Variable, often unavailable |
*CNV detection via NGS with complementary MLPA confirmation when needed.
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics, I emphasize that this NGS test provides definitive molecular diagnosis for distal arthrogryposis type 1B, but results must always be interpreted alongside clinical findings and family history. Pre- and post-test genetic counseling is mandatory for informed decision-making. Do not discontinue prescribed medications or physical therapy without consulting your doctor.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Precautions
- Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
- If you have had a blood transfusion within the last 2 weeks, please inform our team to avoid sample rejection.
Exclusion Criteria
- ER Red Flags: Seek emergency care immediately if you or your child develop difficulty breathing, severe worsening of joint contractures, or feeding difficulties prior to or after test.
- This genetic test is not intended as a stand-alone diagnostic tool; clinical correlation is mandatory.
Patient FAQ & Clinical Guidance
1. What does the MYBPC1 gene test detect and who should consider it?
Snippet: The MYBPC1 gene test detects pathogenic variants linked to distal arthrogryposis type 1B, indicated for individuals with congenital distal joint contractures.
This test is indicated for newborns, children, or adults presenting with bilateral distal joint contractures, clenched fists, clubfoot, and overlapping fingers, without major proximal involvement. A positive result confirms a molecular diagnosis of distal arthrogryposis type 1B (DA1B), enabling accurate genetic counseling for family planning and prognosis. Testing can also be offered to at-risk family members. Our laboratory requires a physician referral and pre-test genetic counseling to draw a detailed pedigree before sample submission.
2. How is the test performed and what is the turnaround time?
Snippet: A blood sample or DNA is collected via a painless home visit, and results are delivered within 3โ4 weeks.
We offer VIP mobile phlebotomy service across the UAE, 8 AM to 11 PM. A trained nurse collects a small blood sample (or a finger-prick for FTA card) from the comfort of your home. Samples are transported in ISO-certified cold-chain containers to our DHA-licensed laboratory. Extracted DNA or stored DNA can also be submitted. The NGS process takes 3โ4 weeks; the final report is reviewed by a clinical geneticist and includes variant classification according to ACMG guidelines. You will receive a secure electronic report and an optional telephonic consultation to discuss findings.
3. Is this test covered by UAE insurance and is genetic counseling included?
Snippet: We offer direct insurance billing verification and include a mandatory pre- and post-test genetic counseling session.
We accept most major UAE health insurance plans. You can send your insurance card via WhatsApp to +971 54 548 8731 for instant verification of coverage. The test price of 2800 AED may be fully or partially covered depending on your policyโs genetic testing benefits. All tests require a pre-test genetic counseling session (included) to explain the testโs implications, obtain informed consent, and draw a pedigree. A post-counseling session to interpret results is also provided at no extra charge. Parental authorization is required for minors.
UAE Regulatory & Data Privacy Adherence
- Licensed by DHA, Facility License No. 1143. Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab: DNA Labs UAE.
- Data protection compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical testing safety and patient consent compliant with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) for quality management.
- Sample collection via ISO certified cold-chain logistics; Home service available 8 AM โ 11 PM daily.
Clinical & Logistical Metadata
| Test Name | MYBPC1 Gene Sequencing for Distal Arthrogryposis Type 1B (NGS) Test |
| Price (AED) | 2800 |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS), full gene coding region ยฑ10 bp exon/intron boundaries |
| ICD-10-CM Code | Q68.8, Z13.79, Z15.89 |
| LOINC Code | 51969-3 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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