Test Price
2,800 AED✅ Home Collection Available
MSX1 Gene Orofacial Cleft Type 5 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- ✓ Diagnostic Accuracy: 99.9% Sensitivity via ISO 9001:2015‑accredited NGS processing.
- ✓ Premium Home Collection: VIP Mobile Phlebotomy with temperature‑controlled cold‑chain transport (8 AM – 11 PM).
- ✓ Clinical Guidance: Post‑test telephonic interpretation by a DHA‑licensed Consultant Medical Genetics.
- ✓ Insurance Support: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This NGS panel analyzes the entire coding region of the MSX1 gene to detect pathogenic variants causing orofacial cleft type 5, a congenital dysmorphology. The test is essential for accurate molecular diagnosis, recurrence risk assessment, and personalized management in neonates, infants, and families.
Next‑Generation Sequencing (NGS) provides full gene coverage with a diagnostic yield exceeding 99% for coding variants, compared to Sanger sequencing which typically covers only selected exons.
| Feature | Our Test (NGS) | Closest Alternative |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) – full gene coverage | Sanger sequencing of selected exons |
| Diagnostic Yield | >99% for coding variants | Limited to ~85% for common mutations |
| Turnaround Time | 3 – 4 Weeks | 5 – 8 Weeks |
| Sample Requirement | 2–3 mL whole blood in EDTA / DNA FTA card | 5–7 mL whole blood + dedicated transport |
| Post‑Test Support | Genetic counseling & tele‑interpretation | Not included |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that a genetic diagnosis is only one piece of the puzzle. An MSX1 pathogenic variant confirms a molecular cause, but each child’s craniofacial care must be guided by a multidisciplinary team including a pediatric surgeon, speech therapist, and orthodontist. This test empowers families with clarity, but it does not replace clinical follow‑up or acute medical intervention.”
Lina Osama Zaki Quteineh
Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Clinical Advisory
Do not discontinue any prescribed medication or feeding plan without consulting your treating physician. Genetic testing may reveal incidental findings; all results must be correlated with the patient’s clinical phenotype. Any clinical decisions must be made under the supervision of a licensed medical professional. This test is conducted in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient Safety – Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent (patient/guardian) or refusal of pre‑test genetic counseling.
- Severe coagulopathy or active bleeding that precludes safe venous sampling.
- Infants with critical airways obstruction due to a large cleft – must be stabilized in hospital prior to home collection.
- Any acute febrile illness or systemic infection that could compromise sample integrity.
- If the patient has received a whole‑blood transfusion in the last 14 days, the test must be postponed.
Seek emergency care if the child shows cyanosis, severe respiratory distress, or inability to feed.
Patient FAQ & Clinical Guidance
1. What does a positive MSX1 result mean for my child’s future?
A positive result confirms a mutation in the MSX1 gene, which is the most common cause of nonsyndromic orofacial cleft type 5 and helps predict recurrence risk for future pregnancies. It provides a clear molecular diagnosis that guides surgical timing and genetic counseling for the family.
2. Is the blood collection painful for my baby and how is it performed at home?
A trained pediatric phlebotomist performs a quick, gentle venipuncture from the arm or heel using a tiny butterfly needle, and the entire process is completed within minutes under strict aseptic conditions. Our VIP Mobile Phlebotomy service operates daily from 8 AM to 11 PM with temperature‑controlled transport.
3. Will my insurance cover the test and how do I verify?
Coverage depends on your plan; we offer direct billing verification within 60 minutes via WhatsApp – just send a photo of your insurance card and the test name to +971 54 548 8731.
4. How long does it take to get results?
The turnaround time is 3–4 weeks from sample receipt. Results are reviewed and signed off by our Consultant Medical Genetics before release.
UAE Regulatory & Data Privacy Adherence
This test complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, stored securely, and accessible only to the treating physician and the patient. Results are validated under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and processed in a DHA‑licensed facility.
Clinical & Logistical Metadata
| Test Name | MSX1 Gene Orofacial Cleft Type 5 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood (2-3 mL EDTA) or DNA FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | Q37.5 (Cleft palate with cleft lip, unilateral) / Q37.9 (Cleft palate with cleft lip, unspecified) |
| LOINC Code | 94709-5 (MSX1 gene targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DNA Labs UAE | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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