Test Price
2,800 AED✅ Home Collection Available
MMP2 Gene Multicentric Osteolysis, Nodulosis, and Arthropathy Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation provided by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MMP2 gene test identifies pathogenic variants causing Multicentric Osteolysis, Nodulosis, and Arthropathy (MONA) syndrome using Next‑Generation Sequencing (NGS). This high‑throughput method covers the full coding region and flanking intronic sequences for comprehensive variant detection.
| Feature | Our Test (NGS‑based) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | High‑throughput NGS (full gene & flanking regions) | Targeted Sanger sequencing (limited to known variants) |
| Diagnostic Sensitivity | 99.9% | ~85% (misses novel or deep intronic mutations) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
Physician Insight & Safety Protocols
"As a clinical geneticist, I emphasise that the MMP2 test offers exceptional accuracy, but results must be integrated with a thorough clinical evaluation and three‑generation family history. Genetic counselling is essential before and after testing to ensure informed decision‑making."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Note
Genetic test results do not replace your current treatment plan. Do not discontinue or alter any prescribed medications without consulting your healthcare provider.
Safety & Exclusion Criteria
- Exclusion: Patients with active severe infection or haemodynamic instability should postpone elective blood draw. Known anaphylaxis to antiseptics must be reported.
- Emergency Red Flags: Seek urgent care if you experience acute worsening of joint pain, fever >38.5°C, uncontrolled bleeding, or signs of deep vein thrombosis after specimen collection.
- Pre‑Test Requirement: Provide clinical history, family pedigree, and complete a genetic counselling session prior to testing.
Patient FAQ & Clinical Guidance
1. What is Multicentric Osteolysis, Nodulosis, and Arthropathy (MONA) syndrome?
MONA syndrome is a rare autosomal recessive disorder characterized by progressive bone loss, skin nodules, and joint deformities caused by mutations in the MMP2 gene. Diagnosis via this genetic test confirms the underlying cause and guides multidisciplinary management.
2. How is the test performed and what sample is needed?
The test requires a peripheral blood sample, extracted DNA, or a dried blood spot on an FTA card. Sample collection is performed by a licensed phlebotomist either at our facility or via our VIP home collection service (8 AM – 11 PM). The specimen is analysed using next‑generation sequencing to scan the entire MMP2 gene.
3. What do the results mean and what follow‑up is needed?
A positive result confirms the diagnosis of MMP2‑related MONA syndrome. Follow‑up includes genetic counselling, evaluation by a dermatologist for nodulosis, orthopaedic assessment for osteolysis, and rheumatology consultation for arthropathy. A negative result significantly reduces but does not completely exclude the condition; further clinical assessment is advised.
UAE Regulatory & Data Privacy Adherence
Data Protection: Your genetic data is processed in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability ensuring patient consent and safety.
Accreditations: DNA Labs UAE operates under DHA Facility License No. 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) for quality management.
Clinical & Logistical Metadata
| Test Name | MMP2 Gene Sequencing (NGS) – Multicentric Osteolysis, Nodulosis, and Arthropathy |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral blood, extracted DNA, or dried blood spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene coding and flanking regions |
| ICD‑10‑CM Code | M89.50 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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