Test Price
2,800 AED✅ Home Collection Available
MMP2 Gene Multicentric Osteolysis, Nodulosis, and Arthropathy Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين MMP2 لمتلازمة تحلل العظام متعدد المراكز والعقيدات واعتلال المفاصل في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation provided by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
ملخص تنفيذي
نحن نقدم اختبار تسلسل الجيل التالي لجين MMP2 بدقة تشخيصية تصل إلى 99.9%، مع خدمة سحب الدم في المنزل على مستوى المستشفيات، وتوجيهات سريرية بعد الفحص. امتثالاً للمرسوم بقانون اتحادي رقم 41 لعام 2024 وقانون حماية البيانات الشخصية في الإمارات، جميع النتائج محمية بموجب ISO 9001:2015.
Federal Decree-Law No. 41 of 2024 (Art. 87), CDS Law 2026 (Minors), UAE PDPL (Data Privacy) fully respected.
Overview
The MMP2 gene test identifies pathogenic variants causing Multicentric Osteolysis, Nodulosis, and Arthropathy (MONA) syndrome using Next‑Generation Sequencing (NGS). يكتشف تحليل جين MMP2 الطفرات المسببة لمتلازمة تحلل العظام متعدد المراكز والعقيدات واعتلال المفاصل.
| Feature | Our Test (NGS‑based) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | High‑throughput NGS (full gene & flanking regions) | Targeted Sanger sequencing (limited to known variants) |
| Diagnostic Sensitivity | 99.9% | ~85% (misses novel or deep intronic mutations) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
Primary Clinical Intent: Diagnosis of MMP2‑related multicentric osteolysis, nodulosis, and arthropathy; carrier screening; differential diagnosis of skeletal dysplasias with skin involvement.
Key Specialists Involved: Dermatologist (evaluates nodulosis), Medical Geneticist (interprets variant pathogenicity, genetic counselling), Oncologist (excludes malignant bone lesions presenting as osteolysis).
Physician Insight & Safety Protocol
"As a physician, I appreciate the uncertainty surrounding rare genetic diagnoses. The MMP2 test is highly accurate, but results must be interpreted alongside clinical symptoms and a detailed family history. Please discuss all findings with your specialist to determine the most appropriate care path."
— Dr. Prabhakar Reddy, DHA License: 61713011
⚠️ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Genetic test results do not replace current treatment plans.
Safety & Exclusion Criteria
- Exclusion: Patients with active severe infection or haemodynamic instability should postpone elective blood draw. Known anaphylaxis to antiseptics must be reported.
- Emergency Red Flags: Seek urgent care if you experience acute worsening of joint pain, fever >38.5°C, uncontrolled bleeding, or signs of deep vein thrombosis after specimen collection.
- Pre‑Test Requirement: Provide clinical history, family pedigree, and complete a genetic counselling session prior to testing.
Pre‑Test Information:
A recent clinical summary and a three‑generation pedigree chart are mandatory. No fasting is required; the sample (blood, extracted DNA, or one drop on FTA card) will be collected by a licensed phlebotomist.
Patient FAQ & Clinical Guidance
1. What is Multicentric Osteolysis, Nodulosis, and Arthropathy (MONA) syndrome?
Snippet: MONA syndrome is a rare autosomal recessive disorder characterized by progressive bone loss, skin nodules, and joint deformities caused by mutations in the MMP2 gene.
متلازمة تحلل العظام متعدد المراكز والعقيدات واعتلال المفاصل هي اضطراب وراثي نادر يتميز بفقدان تدريجي للعظام وظهور عقيدات جلدية وتشوهات مفصلية نتيجة طفرات في جين MMP2.
2. How is the test performed and what sample is needed?
Snippet: The uses a blood sample, extracted DNA, or a single drop of blood on an FTA card analyzed via Next‑Generation Sequencing for comprehensive MMP2 gene analysis.
يتم إجراء التحليل باستخدام عينة دم أو حمض نووي مستخلص أو قطرة دم على بطاقة FTA ويتم تحليلها عبر تقنية تسلسل الجيل التالي للفحص الشامل لجين MMP2.
3. What do the results mean and what follow‑up is needed?
Snippet: A positive result confirms the diagnosis of MMP2‑related MONA syndrome; genetic counselling and coordinated care with a dermatologist, orthopaedic surgeon, and rheumatologist are essential for management.
النتيجة الإيجابية تؤكد تشخيص متلازمة تحلل العظام متعدد المراكز والعقيدات واعتلال المفاصل المرتبطة بجين MMP2؛ ومن الضروري الاستشارة الوراثية والمتابعة مع طبيب الأمراض الجلدية وجراح العظام وطبيب الروماتيزم.
Home Collection Available 8 AM – 11 PM | WhatsApp +971 54 548 8731
DHA Facility License: 9834453 | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
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