Test Price
2,800 AEDโ Home Collection Available
MEIS2 Gene Cleft Palate, Cardiac Defects, and Mental Retardation Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
The MEIS2 gene next-generation sequencing (NGS) test delivers a comprehensive molecular diagnosis for the rare syndrome encompassing cleft palate, congenital heart defects, and intellectual disability. Performed in our ISO 9001:2015 accredited laboratory under DHA Facility License 1143, the assay achieves a diagnostic sensitivity exceeding 99.9%. Logistics include temperature-controlled cold-chain home collection via VIP mobile phlebotomy (08:00โ23:00 daily) and telephonic post-test clinical guidance by a consultant medical geneticist.
Test Overview & Methodology
This next-generation sequencing assay comprehensively screens the entire MEIS2 gene for pathogenic variants associated with cleft palate, congenital heart defects, and intellectual disability. The test delivers a molecular diagnosis with greater than 99.9% sensitivity from a peripheral blood sample, extracted DNA, or a dried blood spot on an FTA card. Full gene coverage ensures detection of rare and novel variants that targeted hotspot panels may miss.
| Feature | Our MEIS2 NGS Test | Closest Alternative (Sanger Panel) |
|---|---|---|
| Precision | >99.9% sensitivity and specificity | ~95% sensitivity, hotspot-limited |
| Method | NGS โ full gene coverage including all coding regions | Sanger sequencing โ selected exons only |
| Speed | 3 to 4 weeks (ISO-certified lab) | 4 to 6 weeks (no ISO guarantee) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA: 9294403) โ Consultant Medical Genetics: In my practice, I emphasise that a positive MEIS2 finding enables early surgical planning for cleft palate, cardiac monitoring, and tailored educational support. However, a negative result does not eliminate the clinical suspicion if features strongly point to the syndrome. Always correlate molecular data with the full clinical phenotype and discuss reproductive implications with a genetic counsellor.
Medication Advisory
Do not discontinue any prescribed medication without consulting your treating physician. Genetic results should complement, not replace, ongoing clinical management.
Safety and Exclusion Criteria
- Not suitable for individuals with active bleeding disorders or inability to provide a blood or DNA sample.
- For infants and neonates, only DHA-licensed paediatric phlebotomists perform collection.
- Emergency red flags: If your child develops cyanosis, severe feeding difficulties, or respiratory distress, seek immediate emergency care without waiting for genetic results.
Patient FAQ & Clinical Guidance
1. What is the MEIS2 gene NGS test and why is it performed?
This test sequences the entire MEIS2 gene to detect pathogenic variants causing cleft palate, congenital heart defects, and intellectual disability. It is indicated for patients with clinical features suggestive of MEIS2-related syndrome, enabling molecular confirmation, guiding surgical and educational interventions, and informing recurrence risk for families. The NGS method covers all coding regions, uncovering rare variants that targeted panels cannot detect.
2. How is the sample collected and what is the turnaround time?
A peripheral blood sample, extracted DNA, or a single dried blood spot on an FTA card is collected via our VIP mobile phlebotomy service. A DHA-licensed nurse arrives at your location between 08:00 and 23:00, follows temperature-controlled cold-chain protocols, and delivers the specimen to our ISO 9001:2015 certified laboratory. Results are reported within 3 to 4 weeks. Urgent samples may be prioritised upon medical request.
3. Are results confidential and compliant with UAE health data laws?
Yes, all genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Results are delivered through encrypted communication channels exclusively to authorised recipients. Your information is never shared without explicit consent.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: DNA Labs UAE fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent processes adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is processed, stored, and transmitted using enterprise-grade encryption and access controls.
Laboratory Accreditation: Our facility operates under DHA Facility License 1143 and maintains ISO 9001:2015 certification, ensuring rigorous quality management across all testing phases.
Clinical & Logistical Metadata
| Test Name | MEIS2 Gene Cleft Palate, Cardiac Defects, and Mental Retardation Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or FTA Card (Dried Blood Spot) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | Q87.8, Q35.9, Q24.9, F70.9 |
| LOINC Code | 81264-1 |
| DHA Facility License & Laboratory Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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