Test Price
2,800 AED✅ Home Collection Available
MAFB Gene – Multicentric Carpotarsal Osteolysis Syndrome (MCTO) Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين MAFB لمتلازمة التحلل العظمي الرسغي الرصغي متعددة المراكز (MCTO) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
يُجري مختبرنا فحصاً جينياً متطوراً لتسلسل جين MAFB لتشخيص متلازمة التحلل العظمي الرسغي الرصغي متعددة المراكز (MCTO)، وفق أعلى معايير الجودة بترخيص هيئة الصحة بدبي وشهادة ISO 9001:2015، مع خدمة سحب منزلي واستشارة وراثية هاتفية لضمان الدقة والراحة.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS & Sanger confirmation.
- ✓ Premium Logistics: Hospital‑grade Home Collection (8 AM‑11 PM) with ISO Certified Cold‑Chain transport and VIP Mobile Phlebotomy.
- ✓ Clinical Guidance: Complimentary telephonic post‑test counselling with a clinical geneticist for result interpretation.
- ✓ Insurance: Direct billing verification and pre‑approval via WhatsApp at +971 54 548 8731 – we handle your policy documents securely.
Comprehensive Clinical Overview
The MAFB Gene NGS Test is a definitive molecular diagnostic tool for Multicentric Carpotarsal Osteolysis Syndrome (MCTO), a rare autosomal dominant skeletal dysplasia characterized by progressive osteolysis of the carpal and tarsal bones, often accompanied by dermatological and immunological manifestations. This assay sequences the entire coding region and splice sites of the MAFB gene, uncovering pathogenic variants with pinpoint accuracy.
يحدد هذا الاختبار الطفرات المسببة للمرض بدقة متناهية، مما يمكّن الأطباء من وضع خطة علاجية شخصية ومراقبة تطور الحالة مبكرًا.
| Feature | Our DHA‑Certified MAFB NGS Test | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Target Gene | MAFB single‑gene deep coverage | All ~20,000 genes; MAFB coverage can be shallow |
| Methodology | NGS (Illumina® NovaSeq) + Sanger confirmation | NGS whole‑exome; often no orthogonal validation |
| Diagnostic Sensitivity | 99.9% | ~95% (varies by capture kit) |
| Turnaround Time | 3–4 weeks | 6–10 weeks |
| Cost (AED) | 2,800 | 5,000–8,000 |
| Clinical Utility | Immediate, actionable result for MCTO; no incidental findings | Many incidental findings; requires complex interpretation |
Physician Insight & Safety Protocol
“We deeply understand the anxiety a rare diagnosis like MCTO can bring – our team is here to support you with compassion and clinical expertise. This test offers a highly sensitive molecular diagnosis, but it must be interpreted in conjunction with full clinical and radiological assessment. Please remember that a negative result does not fully exclude the syndrome; variant reclassification may occur later, so regular follow‑up with your specialist remains vital.”
— Dr. Prabhakar Reddy, DHA License: 61713011, Clinical Pathologist & Genomic Specialist
⚠ Do not discontinue or adjust any prescribed medication without consulting your treating doctor.
Genetic test results are advisory and must be integrated into your overall care plan. Abruptly stopping medications can lead to serious health risks.
Exclusion Criteria & Emergency Red Flags
- You are under 18 years old without a legal guardian’s informed consent (as per UAE CDS Law 2026).
- You have a severe bleeding disorder where routine venipuncture is contraindicated.
- You are unable to provide valid informed consent for genetic testing due to cognitive or legal reasons.
- You are currently in an acute medical crisis that requires immediate emergency care.
- Rapidly worsening joint pain, swelling, or inability to bear weight.
- Signs of renal involvement – decreased urine output, facial swelling, or persistent vomiting.
- High fever with chills accompanied by new skin lesions or ulcerations.
- Sudden visual disturbance or severe headache (possible CNS involvement).
A mandatory pre‑test genetic counselling session is required to explain the test’s scope, limitations, and implications under UAE healthcare regulations.
Patient FAQ & Clinical Guidance
🧬 How accurate is this MAFB gene test, and can it miss mutations?
🧬 ما مدى دقة تحليل جين MAFB وهل يمكن أن يفشل في اكتشاف الطفرة؟
Our DHA‑certified achieves 99.9% diagnostic sensitivity by sequencing all coding exons with Sanger confirmation, leaving virtually no room for false negatives. We use deep NGS coverage (>1000x) of the entire MAFB gene, including flanking splice regions, and every pathogenic variant is orthogonally validated by Sanger sequencing. However, variants in deep intronic or regulatory regions may not be detected, and large deletions/duplications might require supplementary MLPA analysis. Your genetic counsellor will discuss these limitations transparently before sampling. يصل حساسية الاختبار التشخيصي إلى 99.9% بفضل تغطية عميقة للجين والتأكيد بتقنية سانجر. لا يمكن استبعاد الحذف الكبير أو الطفرات العميقة بالكامل، لذا تُكمل الاستشارة الوراثية الصورة الكاملة.
⏳ How soon will I get my results, and what should I do after?
⏳ متى أحصل على النتائج وماذا أفعل بعد استلامها؟
Your final report is ready in 3–4 weeks, and our genetic counsellor will call you to explain every finding and coordinate with your specialist. Once the sequencing is complete and validated, we issue a bilingual DHA‑compliant report that includes the variant description, pathogenicity classification, and clinical correlation. You will receive a tele‑consultation link; never attempt to interpret the result alone. We then send the approved report directly to your dermatologist, rheumatologist, or orthopaedic surgeon so they can adjust your management plan immediately. يتم تسليم التقرير خلال ٣ إلى ٤ أسابيع مع جلسة استشارية هاتفية لشرح النتائج وتنسيق العلاج مع طبيبك المعالج.
🏠 Can the sample be collected at home, and is insurance accepted?
🏠 هل يمكن سحب العينة في المنزل وهل تقبلون التأمين الصحي؟
Yes, our VIP mobile phlebotomy team visits your home from 8 AM to 11 PM across all UAE emirates, and we verify direct insurance billing via WhatsApp before your appointment. Once you provide your insurance details, our coordinators obtain a pre‑authorisation code, and the collection nurse arrives with an ISO 9001:2015‑certified cold‑chain kit. For self‑pay patients, the fee is 2,800 AED. A small finger‑prick DBS (dried blood spot) option on FTA card is also available for children with delicate veins, though venous blood remains the gold standard. نعم، نوفر خدمة سحب منزلي مع فريق تمريض متنقل على مدار الساعة، ونتكفل بالتحقق من التغطية التأمينية عبر واتساب قبل الموعد.
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians