Test Price
2,800 AED✅ Home Collection Available
LIG4 Gene (LIG4 Syndrome) Genetic Test in the UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين LIG4 (متلازمة LIG4) بتقنية التسلسل الجيني الشامل NGS في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Clinical Brief & Service Guarantee
- Diagnostic Precision: 99.9% analytical sensitivity and specificity via ISO 9001:2015 accredited NGS, verified against 2026 AI‑curated genomic databases and DHA molecular standards.
- Premium Logistics: Paid hospital‑grade home collection with ISO‑certified cold‑chain transport and VIP mobile phlebotomy (8 AM – 11 PM, 7 days).
- Clinical Guidance: Compulsory pre‑ and post‑test genetic counselling, telephonic interpretation by DHA‑licensed molecular genomicists and clinical geneticists.
- Insurance & Billing: Direct billing verification via secure WhatsApp at +971 54 548 8731 – most major UAE insurers accepted.
ملخص تنفيذي: يوفر تحليل جين LIG4 بتقنية التسلسل من الجيل التالي تشخيصاً دقيقاً لمتلازمة LIG4 – وهو اضطراب وراثي نادر يجمع بين نقص المناعة المشترك وتشوهات جلدية وهيكلية واستعداد للأورام. جميع خدماتنا معتمدة من هيئة الصحة بدبي وفقاً للمرسوم بقانون اتحادي رقم 41 لسنة 2024 ومطابقة لنظام حماية البيانات الشخصية الإماراتي.
Clinical & Technical Overview
LIG4 (DNA ligase IV) is essential for V(D)J recombination and non‑homologous end joining; biallelic pathogenic variants cause LIG4 syndrome – a radiosensitive severe combined immunodeficiency with microcephaly, photosensitivity, bone marrow failure, and a strikingly elevated malignancy risk. This NGS panel sequences the entire coding region and splice junctions of the LIG4 gene, providing the highest diagnostic yield for both classic and atypical presentations.
| Parameter | Our NGS Test (2026 UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Target Region | Full gene (coding ± splice sites, ±10 bp) | Single‑exon or amplicon only |
| Sensitivity | >99.9% for SNVs, indels, CNVs (confirmed by MLPA backup) | ~90% for SNVs; cannot detect large CNVs |
| Turnaround Time | 21–28 calendar days | 35–45 calendar days |
| UAE DHA/MOHAP Alignment | Fully compliant; ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Often non‑standardised |
Physician Insight & Safety Protocol
"As a DHA‑licensed molecular pathologist, I want to emphasise that an LIG4 genetic diagnosis is not a verdict but a roadmap. Even a confirmed pathogenic variant requires meticulous clinical correlation with immunological, dermatological, and oncological findings – this gene’s expressivity can vary. Every result must be discussed with a multidisciplinary team to personalise surveillance and treatment."
— Dr. PRABHAKAR REDDY, DHA License 61713011
⚠ Medication Caution
Do not discontinue any prescribed immunosuppressive, dermatologic, or chemopreventive medication without explicit instruction from your treating physician. Abrupt cessation can precipitate severe flares or opportunistic infections.
Exclusion Criteria & Emergency Red Flags
- Uncontrolled active infection requiring hospitalisation.
- Profound neutropenia (ANC <0.5 × 10⁹/L) without pre‑test stabilisation.
- New‑onset neurological deficit, seizures, or loss of consciousness – proceed to ER immediately.
- Severe bleeds, petechiae, or haematomas suspicious for bone marrow failure – call 998.
- Pregnancy (relative exclusion; defer until post‑partum unless urgent oncogenetic counselling required).
Patient FAQ & Clinical Guidance
1. What is LIG4 syndrome and why is this NGS test the gold standard?
LIG4 syndrome is a rare autosomal recessive disorder combining severe combined immunodeficiency, microcephaly, photosensitivity, and cancer predisposition. This NGS fully sequences the LIG4 gene, detecting >99.9% of both point mutations and large deletions missed by older methods.
2. من يجب أن يخضع لتحليل جين LIG4؟
يوصى بإجراء هذا التحليل للأطفال والبالغين الذين يعانون من نقص المناعة المشترك المتلازمي، أو صغر الرأس، أو حساسية للضوء، أو تاريخ عائلي للإصابة بالأورام اللمفاوية أو ابيضاض الدم. كما يُستخدم للكشف عن الحاملين للمرض في العائلات المعروفة.
3. How should I interpret a negative result?
A negative NGS panel rules out pathogenic variants within the LIG4 coding region, but if clinical suspicion remains high, whole-exome or whole-genome sequencing may be warranted. Consult your geneticist for ongoing surveillance protocols.
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