Test Price
2,800 AED✅ Home Collection Available
LEFY2 Gene Left-Right Axis Malformations Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Precision NGS Sequencing for Definitive Diagnosis
99.9% Diagnostic Sensitivity
ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
VIP Mobile Phlebotomy & Cold-Chain Home Collection
Premium hospital-grade home collection, 8 AM – 11 PM.
Post-Test Clinical Guidance
Telephonic consultation with a DHA-licensed genetic counsellor to interpret results.
Direct Billing Verification
Confirm your insurance coverage instantly via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The LEFTY2 NGS test sequences the entire coding region of the LEFTY2 gene to identify pathogenic variants linked to left-right axis malformations (heterotaxy, situs inversus). This single‑gene sequencing offers a rapid, focused alternative to whole-exome analysis for dysmorphology panels. The method uses targeted amplicon enrichment on the Illumina® platform, achieving 100% coverage of LEFTY2 with read depth exceeding 100×.
| Feature | Our LEFTY2 NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Diagnostic Precision | 100% coverage of LEFTY2 with depth >100× | Variable coverage; may miss deep intronic variants |
| Method | NGS (Illumina® platform) – targeted amplicon enrichment | Exome capture + NGS, longer bioinformatics |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Cost | 2,800 AED (all-inclusive) | 4,500 – 6,000 AED |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant in Medical Genetics, I emphasise that a positive LEFTY2 result must be interpreted alongside echocardiography and abdominal imaging findings — never in isolation. This test provides families with a definitive molecular diagnosis, enabling tailored surveillance and informed reproductive decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Reg: 9294403
Advisory: Medication and Clinical Considerations
⚠️ Medication Warning
Do not discontinue or adjust any prescribed medication (e.g., cardiac, anti-seizure) without explicit instruction from your treating physician. This test does not replace urgent clinical assessment. Anticoagulant therapy requires medical clearance before phlebotomy; an FTA card may be used as a safe alternative.
Safety Exclusion Criteria & Red Flags
- Acute febrile illness or hemodynamic instability – delay collection until stable.
- Inability to provide informed consent (mandatory pre-test genetic counselling).
- Concurrent anticoagulant therapy requires medical clearance; use FTA card as alternative if venipuncture poses risk.
- Emergency red flags: Severe cyanosis, respiratory distress, or altered consciousness — proceed directly to the nearest emergency department; testing is not a priority in crisis.
Patient FAQ & Clinical Guidance
1. What does the LEFTY2 NGS test detect, and who should consider it?
This test identifies pathogenic variants in the LEFTY2 gene, confirming the molecular cause of left-right axis malformations such as heterotaxy or situs inversus. It is recommended for infants, children, or adults with clinical features suggestive of laterality defects, including complex congenital heart disease, abdominal situs abnormalities, or polysplenia/asplenia.
2. How accurate is the LEFTY2 NGS, and what sample types are accepted?
Diagnostic sensitivity exceeds 99.9% for single nucleotide variants and small indels. Acceptable sample types include whole blood (collected in EDTA tubes), extracted DNA, or FTA card. Home collection is available daily from 8 AM to 11 PM via VIP mobile phlebotomy with temperature-controlled cold-chain logistics.
3. Will my UAE health insurance cover the cost, and how do I arrange home collection?
Coverage is confirmed instantly via WhatsApp (+971 54 548 8731). Once verified, our team schedules an ISO-certified cold-chain home visit within 4 hours. You can also book directly through our website or by calling the laboratory.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143 and fully complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring secure handling of genetic and health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing telemedicine and digital health records.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – regulating patient consent, test accuracy, and clinical accountability.
All genetic samples are processed under ISO 9001:2015 quality management standards within our Dubai Healthcare City laboratory.
Clinical & Logistical Metadata
| Test Name | LEFY2 Gene Left-Right Axis Malformations Genetic Test (NGS) |
| Price (AED) | 2,800 AED (all-inclusive, no hidden fees) |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – targeted amplicon enrichment on Illumina® platform |
| ICD-10-CM Code | Q89.3 (Situs inversus), Q20.8 (Heterotaxy) |
| LOINC Code | 21636-6 (Gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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