Test Price
2,800 AED✅ Home Collection Available
LAS1L Gene Wilson-Turner Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Diagnostic Accuracy: 99.9% sensitivity across the entire LAS1L coding region via ISO‑compliant NGS processing.
Premium Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
Post‑Test Guidance: Telephonic consultation with a consultant medical geneticist to interpret results and guide management.
Insurance Verification: Direct billing inquiry via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The LAS1L Gene Wilson-Turner Syndrome Genetic Test delivers definitive sequencing of the entire LAS1L coding region and all splice‑site boundaries using next‑generation sequencing (NGS). This comprehensive analysis identifies pathogenic and likely pathogenic variants responsible for X‑linked Wilson‑Turner syndrome, providing neurologists and genetic counselors with the molecular evidence needed for precise diagnosis, tailored neurodevelopmental interventions, and informed family counseling.
Methodology: Next‑Generation Sequencing (NGS) on an Illumina platform with deep coverage of all coding exons and flanking intronic regions. All variants are confirmed by Sanger sequencing when required by laboratory protocol.
Test Comparison: NGS Panel vs. Single‑Gene Sanger Sequencing
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Detection Sensitivity | 99.9% (all coding exons + splice sites) | ~97% (targeted regions only) |
| Method | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Turnaround Time | 3–4 Weeks | 5–7 Weeks |
| Coverage | Full gene, deep coverage | Selected exons, limited coverage |
Physician Insight & Safety Protocols
“Genetic test results must always be interpreted within the complete clinical context. A confirmed LAS1L pathogenic variant enables targeted neurodevelopmental management and accurate recurrence risk counseling for the family. However, molecular confirmation does not substitute for a detailed neurological examination and developmental assessment. Pre‑test genetic counseling is essential to obtain fully informed consent and to set realistic expectations about possible findings, including variants of uncertain significance.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
Important Medication Warning
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent, including minors without legally valid guardian consent as per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Pregnant women without a clear clinical indication due to interpretive limitations in the obstetric context.
- Patients with acute febrile illness or hemodynamic instability that precludes safe blood collection.
- Immediate emergency care is required if the patient experiences new‑onset seizures, severe neurological deterioration, or acute encephalopathy; this test is not an emergency diagnostic tool.
Patient FAQ & Clinical Guidance
1. What is Wilson-Turner syndrome and how is it inherited?
Wilson‑Turner syndrome is an X‑linked recessive neurodevelopmental disorder caused by pathogenic variants in the LAS1L gene. It primarily affects males and is characterized by intellectual disability, childhood‑onset obesity, gynecomastia, and distinctive facial features. Female carriers are typically asymptomatic due to X‑chromosome inactivation. Early genetic diagnosis enables tailored educational support, weight management strategies, and accurate recurrence risk counseling for families planning future pregnancies.
2. How is the LAS1L gene test performed and what sample is required?
The test requires a peripheral whole blood sample, extracted DNA, or a dried blood spot on an FTA card. Analysis is performed using next‑generation sequencing (NGS) to interrogate the entire LAS1L coding region and all exon‑intron boundaries. Our VIP mobile phlebotomy team collects samples using ISO‑certified temperature‑controlled cold‑chain logistics, available daily from 8 AM to 11 PM. Results are typically ready within 3–4 weeks from sample receipt at the laboratory.
3. How accurate is this genetic test and what do the results mean?
This NGS‑based test achieves a diagnostic sensitivity exceeding 99.9% for detecting sequence variants in the LAS1L gene. Results are classified according to ACMG/AMP guidelines as pathogenic, likely pathogenic, or variant of uncertain significance. A positive result confirms a molecular diagnosis of Wilson‑Turner syndrome, guiding early intervention and family planning. A negative result reduces but does not entirely exclude the syndrome; additional genetic or metabolic investigations may be warranted based on clinical suspicion. Every report includes a telephonic post‑test consultation with a consultant medical geneticist.
UAE Regulatory & Data Privacy Adherence
All diagnostic services at DNA Labs UAE operate in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genetic data is encrypted, access‑controlled, and processed solely for the purpose of clinical diagnosis and counseling. Clinical safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. The laboratory maintains ISO 9001:2015 certification and follows CAP/CLIA-equivalent quality standards.
Clinical & Logistical Metadata
| Test Name | LAS1L Gene Wilson-Turner Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Q87.8, E34.8 |
| LOINC Code | 93478-2 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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