Test Price
2,800 AEDโ Home Collection Available
KRT14 Gene Epidermolysis Bullosa Simplex, Dowling-Meara Type DNA Test in UAE | 2800 AED
Executive Summary & Core Metrics
โ Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
๐ฆ Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection โ Available daily from 8 AM to 11 PM.
๐ฉบ Clinical Guidance
Telephonic Post-Test Clinical Guidance in Result Interpretation by Specialist Team.
๐ณ Insurance
Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Comprehensive KRT14 Gene Analysis for Epidermolysis Bullosa Simplex (Dowling-Meara)
This targeted Next-Generation Sequencing (NGS) test detects pathogenic variants in the KRT14 gene responsible for Epidermolysis Bullosa Simplex, Dowling-Meara type, a severe subtype characterized by generalized blistering at birth. Results guide dermatologists and geneticists in confirming diagnosis, predicting prognosis, and enabling reproductive planning.
| Feature | Our KRT14 NGS Test | Closest Alternative (SingleโSite/Multiple Ligation) |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity/specificity, full gene sequencing | Limited to known hotspot mutations; misses novel/rare variants |
| Methodology | Next-Generation Sequencing (NGS) with 100% coding exon coverage & splice-site analysis | Sanger sequencing of selected exons or MLPA |
| Turnaround Time | 3โ4 weeks from sample receipt | 4โ6 weeks, often with reflex to broader panels |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403), notes: โA definitive genetic diagnosis of Dowling-Meara EBS provides families with clarity regarding prognosis and recurrence risk. This NGS-based KRT14 analysis is highly sensitive, but clinical correlation remains essential for comprehensive management.โ
Medication Advisory
โ ๏ธ Medication Warning: Do not discontinue prescribed medication (e.g., antihistamines, topical antibiotics, or pain management therapies) without consulting your treating physician. Suddenly stopping treatments may worsen blistering or lead to secondary infection.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: This test is not indicated for individuals without clinical suspicion of EB or a positive family history. Minors must have parental consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Sample Rejection: Hemolyzed blood, insufficient DNA quantity, or samples shipped without cold-chain integrity will be rejected and require recollection.
- ER Red Flags: Seek immediate medical attention if you or your child experience widespread, painful blisters with signs of systemic infection (fever, chills, lethargy), difficulty swallowing/breathing, or rapidly progressing skin detachment.
Patient FAQ & Clinical Guidance
1. What is the KRT14 genetic test and how accurate is it for Dowling-Meara EBS?
Snippet Answer: The KRT14 NGS test detects over 99.9% of disease-causing variants in the KRT14 gene with full exon coverage, providing a definitive molecular diagnosis for Dowling-Meara Epidermolysis Bullosa Simplex when combined with clinical evaluation.
2. How is the sample collected and is home collection available in the UAE?
Snippet Answer: A certified phlebotomist performs a peripheral blood draw at your home, office, or hotel, with samples transported under strict ISO cold-chain conditions between 8 AM and 11 PM daily. This is a VIP mobile phlebotomy service with temperature-controlled logistics.
3. What do my results mean for my family and future planning?
Snippet Answer: A positive result confirms autosomal dominant inheritance, enabling genetic counselling for at-risk relatives and informed reproductive options including preimplantation genetic diagnosis (PGD) in accordance with UAE laws.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic testing and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Molecular testing is performed at a DHA-licensed facility under ISO 9001:2015 quality management (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | KRT14 Gene Epidermolysis Bullosa Simplex, Dowling-Meara Type DNA Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral Whole Blood (or FTA card) โ VIP Mobile Phlebotomy & Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) with full coding exon coverage & splice-site analysis |
| ICD-10-CM Code | Q81.0 (Epidermolysis bullosa simplex) |
| LOINC Code | 21663-4 (KRT14 gene mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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