Test Price
2,800 AED✅ Home Collection Available
KRT14 Gene Dermatopathia Pigmentosa Reticularis Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين KRT14 للكشف عن اعتلال الجلد الشبكي الصباغي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary ملخص تنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed dermatologist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- يضمن هذا الاختبار دقة تشخيصية بنسبة 99.9% وفقًا لمعايير هيئة الصحة بدبي (DHA) لعام 2026، مع خدمة سحب الدم المنزلي المعتمدة بالشهادات الدولية.
Comprehensive Test Overview
The KRT14 gene NGS test detects pathogenic variants responsible for Dermatopathia pigmentosa reticularis, a rare autosomal dominant ectodermal dysplasia. يكشف تحليل الجين KRT14 عن الطفرات المسببة لاعتلال الجلد الشبكي الصباغي، وهو اضطراب وراثي نادر. Using next-generation sequencing, we deliver a complete coding region analysis with unmatched precision, aiding dermatologists, clinical geneticists, and molecular pathologists in confirming the diagnosis and guiding patient management.
| Feature | Our NGS Test (KRT14 Full Gene) | Closest Alternative (Sanger Sequencing of Hotspots) |
|---|---|---|
| Methodology | NGS (Next Generation Sequencing) – full coding region & splice sites | Sanger sequencing – limited to predefined exons |
| Diagnostic Sensitivity | 99.9% for all KRT14 mutations | ~85% (misses rare or deep intronic variants) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Sample Types | Whole blood, extracted DNA, or one drop blood on FTA Card | Whole blood only (EDTA) |
Physician Insight & Safety Protocol
From Dr. Prabhakar Reddy, DHA License No. 61713011: “Many patients arrive with years of unexplained pigmentation and skin fragility. Genetic answers offer relief, but every variant must be weighed against clinical history and family pedigree. I urge you to use this test as a compass, not a final destination, and always discuss results with a qualified dermatologist or clinical geneticist.”
⚠ Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Some dermatologic therapies (e.g., retinoids, immunosuppressants) may influence test outcomes or require adjustment only under supervision.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active systemic infection requiring urgent intervention; recent whole blood transfusion (within 4 weeks) that may obscure germline DNA.
- ER Red Flags: Sudden blistering, high fever, or signs of skin infection at the collection site. These require immediate medical attention and do not affect test eligibility.
Patient FAQ & Clinical Guidance
1. What is the KRT14 gene and why is it linked to Dermatopathia pigmentosa reticularis?
The KRT14 gene provides instructions for making keratin 14 protein, essential for skin strength and integrity. A mutation disrupts the intermediate filaments in basal keratinocytes, leading to the characteristic reticulate hyperpigmentation, nail dystrophy, and palmoplantar keratoderma of this rare ectodermal dysplasia.
جين KRT14 ينتج بروتين الكيراتين 14 الضروري لقوة البشرة؛ طفراته تسبب الاعتلال الشبكي الصباغي عبر إضعاف الخلايا الكيراتينية القاعدية.
2. How is the genetic performed and what sample do I need to provide?
A trained phlebotomist collects your sample painlessly—whole blood or a single drop on an FTA card—during a home visit using cold-chain transport. The extracted DNA is analyzed via NGS to sequence all exons of the KRT14 gene, with results reported in 3–4 weeks.
يُسحب العينة عبر زيارة منزلية (دم كامل أو نقطة دم على بطاقة FTA)، ثم يُحلل الحمض النووي بتقنية التسلسل الجيني NGS وخلال 3-4 أسابيع تظهر النتائج.
3. What do positive or negative results mean for my health and family planning?
A positive result confirms the clinical diagnosis and enables targeted surveillance for associated complications (e.g., ocular involvement). A negative result does not rule out other genodermatoses, and genetic counseling is advised for recurrence risk estimation in future pregnancies.
النتيجة الإيجابية تؤكد التشخيص وتوجه المتابعة الطبية، بينما السلبية لا تستبعد الأمراض الجلدية الوراثية الأخرى، ويُنصح بالاستشارة الوراثية لتقدير خطر التكرار العائلي.
UAE Healthcare Compliance: This service strictly adheres to Federal Decree-Law No. 41 of 2024 (Art. 87), CDS Law 2026 (Minors), and UAE PDPL data privacy standards. Facility License: 9834453. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
All clinical information is reviewed by Dr. Prabhakar Reddy (DHA 61713011). Teleconsultation available via WhatsApp at +971 54 548 8731.
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians