Test Price
2,800 AED✅ Home Collection Available
KNL1 Gene MCPH4 Microcephaly Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Test Overview & Methodology
The KNL1 gene NGS test sequences the complete coding region and splice junctions of the KNL1 gene to detect pathogenic variants causing autosomal recessive primary microcephaly type 4 (MCPH4). This targeted analysis provides definitive diagnosis and carrier status determination with superior sensitivity compared to whole exome approaches.
| Feature | Our KNL1 NGS Test | Whole Exome Sequencing (WES) |
|---|---|---|
| Methodology | Full gene NGS (depth >100x) | Exome capture + NGS |
| Diagnostic Yield for MCPH4 | 99.9% sensitivity for KNL1 variants | ~95% coverage, may miss deep intronic changes |
| Turnaround Time | 3–4 Weeks | 8–12 Weeks |
| Price (AED) | 2,800 | 5,000+ |
| Incidental Findings | Minimal – only KNL1 gene | High – may uncover unrelated diseases |
Physician Insight & Safety Protocols
“Every child’s developmental journey is precious. The KNL1 gene test provides critical information for care planning, but clinical correlation with microcephaly measurements and neuroimaging remains essential. I strongly encourage families to pursue genetic counseling before testing to fully understand the implications of results.”
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory Precautions
Critical Reminder
Do not discontinue any prescribed medication without consulting your doctor. Test results may impact clinical management; always discuss with a genetic counselor or referring physician.
ER Red Flags – Seek Immediate Medical Attention
- New‑onset seizures or loss of consciousness.
- Breathing difficulties or cyanosis.
- Sudden deterioration in motor skills or alertness.
Exclusion Criteria
- No clinical suspicion of microcephaly or family history of MCPH4.
- Acute febrile illness or recent blood transfusion (may compromise DNA integrity).
Patient FAQ & Clinical Guidance
1. What is the KNL1 gene microcephaly test?
The KNL1 NGS directly sequences the entire coding region of the KNL1 gene to detect pathogenic variants causing autosomal recessive primary microcephaly type 4, enabling definitive diagnosis and carrier status determination.
2. How is the sample collected in the UAE?
Our DHA‑licensed phlebotomists perform a painless blood draw at your home using ISO‑certified cold‑chain logistics; alternatively, a buccal swab or FTA card sample is available for child‑friendly collection. Our VIP Mobile Phlebotomy service is available daily from 8 AM to 11 PM.
3. What does a positive result mean for my child?
A positive result confirms biallelic pathogenic KNL1 variants, indicating a diagnosis of MCPH4. This guides developmental interventions and genetic counseling, but does not predict the exact severity of intellectual disability. Clinical correlation with imaging and physical exam is essential.
4. How long does the test take?
The turnaround time for our KNL1 gene NGS test is 3–4 weeks from sample receipt. Rush processing may be available upon request.
UAE Regulatory & Data Privacy Adherence
Data Protection Compliance: DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, stored securely, and never shared without explicit patient consent.
Clinical Governance: Testing procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent.
Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under the direct licensing and supervision of the Dubai Health Authority (DHA).
Clinical & Logistical Metadata
| Test Name | KNL1 Gene (MCPH4) Microcephaly Genetic Test – NGS |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral blood (3–5 mL in EDTA) or buccal swab / FTA card |
| Methodology Used | Full-gene NGS (coding regions + splice junctions, depth >100x) |
| ICD-10-CM Code | Q02, Q03.0 |
| LOINC Code | 92822-6 |
| DHA Facility License & Laboratory Address | License No: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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