Test Price
2,800 AED✅ Home Collection Available
IRF6 Gene Orofacial Cleft Type 6 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: We offer precise genetic analysis of the IRF6 gene using advanced next-generation sequencing, fully accredited by DHA and ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). This service includes VIP mobile phlebotomy for home collection with temperature-controlled cold-chain logistics, and telephonic post-test clinical guidance from a Consultant Medical Geneticist. Your data privacy is fully protected under UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance from a Consultant Medical Geneticist for result interpretation and family planning.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test provides comprehensive analysis of the entire IRF6 gene coding region and selected intronic boundaries to identify pathogenic variants associated with orofacial cleft type 6 (Van der Woude syndrome). The test enables precise diagnosis, familial risk assessment, and early intervention planning for affected individuals and their families. Full gene coverage includes deletion and duplication analysis, providing diagnostic sensitivity of 99.9% validated against international reference datasets.
| Feature | Our Test – NGS Panel | Closest Alternative – Traditional Sequencing |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) – full gene coverage with deletion/duplication analysis | Sanger sequencing (targeted) or microarray – may miss deep intronic variants |
| Clinical Sensitivity | 99.9% diagnostic sensitivity, validated against international reference datasets | ~85–90% for coding regions only |
| Turnaround Time | 3 to 4 weeks | 4 to 6 weeks |
| Price (AED) | 2,800 | 3,600+ |
| Sample Options | Blood, Extracted DNA, or One-drop Blood on FTA Card | Blood or DNA only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403) notes: “Interpreting IRF6 genetic results demands careful clinical correlation with dysmorphology findings, family pedigree, and antenatal history. This NGS-based test provides high-confidence identification of pathogenic variants; however, a negative result does not exclude other cleft-associated syndromes. Positive findings should be integrated with a comprehensive clinical evaluation to guide surgical planning, recurrence risk counseling, and multidisciplinary care. We are committed to supporting you and your family throughout this diagnostic journey.”
Advisory – Medication & Clinical Management
⚠ Important Clinical Advisory: Do not discontinue any prescribed medications or alter treatment plans without consulting your physician. Genetic testing results complement but do not replace ongoing medical management. Always follow your healthcare provider’s guidance for feeding support, surgical timing, and developmental monitoring.
Exclusion Criteria & Emergency Red Flags
- Minors without proper consent: Testing of individuals under 18 years requires explicit parental or guardian consent and prior genetic counseling, in full compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability and applicable child protection regulations.
- Acute medical instability: Do not attempt sample collection if the patient is experiencing respiratory distress, severe feeding difficulties, or signs of sepsis related to cleft complications; seek emergency care immediately.
- Unverified clinical indication: Testing without a clearly documented family or personal history of orofacial clefts may lead to insurance denial and unnecessary anxiety. A referral from a qualified physician is required.
- Red Flags for Immediate ER Visit: Cyanosis, choking episodes, projectile vomiting, or apneic spells in an infant with cleft palate or lip require urgent emergency assessment.
Patient FAQ & Clinical Guidance
1. What does the IRF6 gene test detect, and who should consider it?
Snippet Answer: This NGS test identifies pathogenic IRF6 mutations causing orofacial cleft type 6 (Van der Woude syndrome) with 99.9% diagnostic sensitivity, guiding surgical, medical, and family planning decisions.
Clinical utility spans newborns with cleft palate or lip, individuals with a family history of Van der Woude syndrome or isolated clefting, and couples undergoing preconception genetic screening. Pediatricians, neonatologists, clinical geneticists, and maternal-fetal medicine specialists commonly order this test to inform multidisciplinary management.
2. How is the sample collected, and what is the turnaround time?
Snippet Answer: Sample collection uses peripheral blood, extracted DNA, or a painless FTA card drop, with results delivered within 3 to 4 weeks.
Our VIP mobile phlebotomy service operates daily from 8 AM to 11 PM, with temperature-controlled cold-chain logistics ensuring sample integrity from your home to our DHA-licensed laboratory. Prior genetic counseling is recommended before sample collection. Results are delivered electronically and reviewed during a telephonic consultation with a Consultant Medical Geneticist.
3. Is this test covered by insurance, and how is my data protected?
Snippet Answer: Most UAE health insurers provide coverage for this test; we offer direct billing verification via WhatsApp, and all genetic data is protected under UAE PDPL.
Connect via WhatsApp at +971 54 548 8731 for a confidential pre-authorization check. All genetic data is encrypted, stored in DHA-licensed facilities (License No. 1143), and handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection:
- This service strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all genetic and personal data processing.
- Health data handling adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Quality Management System (Cert: INT/EGQ/2509DA/3139).
- DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
- Corporate Lab Branding: DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | IRF6 Gene Orofacial Cleft Type 6 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral blood (whole blood), Extracted DNA, or One-drop Blood on FTA Card – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coverage with deletion/duplication analysis |
| ICD-10-CM Code | Q38.0 (Congenital malformations of lip, not elsewhere classified) / Q37.9 (Unspecified cleft palate with cleft lip) |
| LOINC Code | 81247-9 (Gene targeted mutation analysis, DNA sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians