Test Price
2,800 AEDโ Home Collection Available
HNF1B Gene Maturity-Onset Diabetes of the Young Type 5 Genetic Test in UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This test is conducted at DNA Labs UAE under DHA Facility License 1143, delivering definitive molecular diagnosis for monogenic diabetes.
Test Overview & Methodology
This comprehensive genetic test uses Next Generation Sequencing (NGS) to detect pathogenic variants in the HNF1B gene, enabling precise diagnosis of MODY type 5 โ a monogenic diabetes often misclassified as Type 1 or Type 2. Identification of a causative mutation guides personalized therapy, frequently allowing transition from insulin to oral sulfonylureas.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; full gene coverage | ~99% but limited to known hotspots |
| Methodology | NGS (Massively Parallel Sequencing) | Sanger Sequencing (single region) |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
Physician Insight & Safety Protocols
โIdentifying a pathogenic HNF1B variant transforms diabetes management from lifelong insulin dependence to targeted oral therapy with sulfonylureas. However, genetic results must always be interpreted alongside clinical phenotype and family history. I strongly advise patients to engage their diabetologist both before and after testing to ensure safe, integrated care.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Important Medication Safety Notice
Do not alter or discontinue any prescribed diabetes medication, including insulin or oral hypoglycaemics, without direct consultation with your treating physician. Genetic test results may inform future therapy adjustments but are not a substitute for immediate clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active febrile illness or systemic infection โ reschedule after recovery. Pregnant women require explicit written clearance from their obstetrician.
- Minors: Mandatory parental or legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags: If you experience severe hyperglycemia (blood glucose > 300 mg/dL), symptoms of ketoacidosis (fruity breath, vomiting, confusion), or sudden vision changes, seek emergency medical care immediately โ do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the HNF1B gene test and what does it diagnose?
This test detects pathogenic DNA variants in the HNF1B gene to confirm Maturity-Onset Diabetes of the Young type 5 (MODY5), a genetic form of diabetes. A positive result enables personalised treatment, often allowing a safe transition from insulin to sulfonylurea therapy once MODY5 is molecularly confirmed.
2. How is the sample collected and what is the turnaround time?
A certified phlebotomist collects a small peripheral blood sample during a scheduled home visit, with results delivered within 3 to 4 weeks. Whole blood, extracted DNA, or FTA card samples are all accepted. The collection process is quick and minimally invasive.
3. Are genetic counselling and post-test clinical guidance included?
Yes, the package includes a pre-test genetic counselling session to construct a three-generation family pedigree, plus telephonic post-test clinical guidance from a specialist. This ensures you fully understand the hereditary implications and therapeutic options for yourself and your family members.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed at DNA Labs UAE under DHA Facility License 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE) with ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139). Patient consent and data confidentiality are strictly maintained in accordance with UAE federal standards.
Clinical & Logistical Metadata
| Test Name | HNF1B Gene Maturity-Onset Diabetes of the Young Type 5 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, daily 8 AM โ 11 PM) |
| Methodology Used | Next Generation Sequencing (NGS) โ Massively Parallel Sequencing |
| ICD-10-CM Code | E13.9 |
| LOINC Code | 82939-0 |
| DHA Facility License & Laboratory Address | License 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians