Test Price
2,800 AED✅ Home Collection Available
HADHA Gene Sequencing (Trifunctional Protein Deficiency) – Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation by DHA‑licensed experts.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The HADHA Genetic Test screens the entire coding region of the HADHA gene via Next‑Generation Sequencing to detect pathogenic variants linked to mitochondrial trifunctional protein deficiency, an inborn error of fatty acid oxidation that can cause life‑threatening metabolic crises.
| Feature | Our Test (NGS) | Closest Alternative (Sanger / Panel) |
|---|---|---|
| Precision | Full gene coverage, including deep intronic regions; variant allele frequency ≥5% | Limited to known hotspots; may miss novel or deep intronic mutations |
| Methodology | Next‑Generation Sequencing (Illumina® platform), validated by orthogonal confirmation | Sanger sequencing or targeted panel; lower sensitivity for mosaic variants |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (often prolonged by batch processing) |
Physician Insight & Safety Protocols
“The HADHA NGS test is a powerful diagnostic tool for mitochondrial trifunctional protein deficiency, but its results must always be correlated with clinical and biochemical findings. Pre‑ and post‑test genetic counselling is essential to help patients understand the implications for family planning and metabolic management. A negative result does not exclude all fatty acid oxidation disorders; metabolic challenges and dietary precautions should be maintained until further evaluation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Notice
Do not modify prescribed medications or dietary regimens without consulting your physician.
Trifunctional protein deficiency management involves strict avoidance of fasting and specific dietary adjustments. Genetic test results are not a substitute for continuous metabolic monitoring and emergency protocols.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Hemodynamic instability, ongoing metabolic decompensation, or inability to provide informed consent (for minors, legal guardian consent mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Exclusion: Recent blood transfusion (<2 weeks) may interfere with DNA extraction; reschedule.
- ER Red Flag: Sudden lethargy, vomiting, hypoglycemia, or seizures — immediately seek emergency care; genetic results are not for acute management.
- ER Red Flag: Any sign of acute liver failure or encephalopathy warrants urgent metabolic resuscitation before genetic testing.
Patient FAQ & Clinical Guidance
1. What is the clinical purpose of the HADHA NGS test?
The test identifies pathogenic DNA variants in the HADHA gene that cause mitochondrial trifunctional protein deficiency, enabling precise diagnosis, family screening, and tailored metabolic management.
2. How is the sample collected and transported?
A whole blood sample (or extracted DNA / FTA card) is collected by a certified phlebotomist at your home via our VIP Mobile Phlebotomy service (8 AM‑11 PM). The specimen is transported in a validated cold chain (2‑8°C) to our ISO‑accredited laboratory.
3. Is this test available for minors or children?
Yes, but written informed consent from a legal guardian and a DHA‑approved genetic counselling session prior to sampling are required, in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
UAE Regulatory & Data Privacy Adherence
This genetic test is conducted in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring confidentiality and secure processing of your genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing electronic health records and telemedicine components.
- DHA Standards for Genetic Testing – including mandatory pre‑ and post‑test counselling.
All laboratory procedures are ISO 15189 accredited, and results are released only through secure, encrypted channels.
Clinical & Logistical Metadata
| Test Name | HADHA Gene Sequencing (Trifunctional Protein Deficiency) – NGS |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next‑Generation Sequencing (Illumina®), full gene coding region + flanking intronic regions |
| ICD-10-CM Code | E71.32 (Disorder of fatty acid oxidation) |
| LOINC Code | 82267-7 (HADHA gene full sequencing) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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