Test Price
2,800 AED✅ Home Collection Available
GPR101 Gene – Acromegaly Predisposition (Germline Mutation) Genetic Test in UAE
Executive Summary & Core Metrics
Diagnostic Sensitivity: 99.9% via ISO-accredited processing.
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM.
Post-test telephone consultation for result interpretation.
Insurance verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GPR101 gene is a key regulator of pituitary hyperplasia; germline mutations cause X-linked acrogigantism (X-LAG) with early-onset acromegaly. This NGS test sequences the entire coding region of GPR101 to detect pathogenic variants predisposing to the disease, providing definitive diagnostic and familial risk information.
| Feature | Our GPR101 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity via NGS | ~96% sensitivity, limited to targeted exons |
| Method | Next‑Generation Sequencing (Illumina NovaSeq) | Conventional PCR + Sanger sequencing |
| Turnaround Time | 3-4 Weeks (expedited options available) | 5-8 Weeks, no expedited options |
Physician Insight & Safety Protocols
"Every GPR101 result must be interpreted within the full clinical and family context. A negative test does not exclude acromegaly due to somatic mosaicism or other gene mutations. This test empowers targeted surveillance and early intervention for pituitary adenomas in mutation carriers."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Continuation
⚠ Do Not Discontinue Prescribed Therapy
Do not stop any prescribed medication (e.g., somatostatin analogs, dopamine agonists) without explicit instruction from your treating physician. Abrupt discontinuation may lead to adverse clinical outcomes.
Exclusion & Safety Criteria
- Exclusion: Active severe thrombocytopenia (platelets < 50,000/µL) or coagulopathy precluding safe venipuncture.
- Exclusion: Known allergy to latex or antiseptic agents; alternative materials available upon request.
- Emergency Red Flag: If post‑collection you develop high fever, uncontrolled headache, or visual disturbances, go to the nearest ER immediately.
- Ensure a formal genetic counselling session is completed before sample submission (pedigree chart required).
- Acceptable samples: Whole Blood (EDTA), Extracted DNA (TE buffer), or One Drop Blood on FTA Card.
Patient FAQ & Clinical Guidance
1. What does a positive GPR101 mutation result mean for me and my family?
A positive result confirms a germline GPR101 mutation that significantly elevates the lifetime risk of developing pituitary adenomas and acromegaly, often in childhood or adolescence. Clinical surveillance protocols include regular serum IGF‑1, prolactin, and pituitary MRI scans. First‑degree relatives should be offered cascade testing.
2. How accurate is the NGS method compared to older genetic tests?
Our NGS delivers 99.9% analytical sensitivity and near‑complete coverage of the GPR101 coding region, far exceeding the accuracy and resolution of traditional Sanger sequencing. This method can detect point mutations, small insertions/deletions, and copy‑number variants that may be missed by targeted approaches.
3. Will my insurance cover the cost and do you assist with the paperwork?
We provide direct billing verification via WhatsApp (+971 54 548 8731) before your collection; many UAE insurers reimburse medically indicated genetic tests like GPR101. Our team will help you obtain pre‑approval, and we follow UAE PDPL guidelines to protect your genetic data securely.
UAE Regulatory & Data Privacy Adherence
This test and its data handling comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic information is stored securely and accessed only by authorized personnel under strict ethical guidelines.
Clinical & Logistical Metadata
| Test Name | GPR101 Gene – Acromegaly Predisposition (Germline Mutation) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3-4 weeks (expedited options available) |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA (TE buffer), or One Drop Blood on FTA Card |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) |
| ICD-10-CM Code | Z15.89 (Genetic susceptibility to other disease) |
| LOINC Code | 92735-7 (Gene mutations found [Identifier] in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians