Test Price
2,800 AED✅ Home Collection Available
GHR Gene Laron Syndrome NGS Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Excellence & Patient-Centred Commitment
- ✓99.9% Diagnostic Sensitivity – ISO‑accredited NGS workflows deliver near‑perfect analytical performance for GHR gene variants associated with Laron syndrome.
- ✓VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM, ensuring sample integrity from your doorstep to our Dubai central lab.
- ✓Telephonic Post-Test Clinical Guidance – A DHA-registered genetic counsellor provides a bilingual explanation of your results, aligning with international interpretive standards.
- ✓Direct Insurance Verification – Our billing team can verify your coverage upon submission of your Emirates ID and insurance policy details.
Test Overview & Methodology
The GHR Gene Laron Syndrome NGS Test interrogates the entire coding region and splice sites of the growth hormone receptor (GHR) gene to confirm or exclude growth hormone insensitivity (Laron syndrome) in children and adults presenting with severe short stature and a characteristic biochemical profile. This assay is optimized to detect single nucleotide variants and small insertions/deletions with high analytical confidence.
| Feature | Our NGS Test (DNA Labs UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Target Region | All GHR exons + splice sites (±20 bp) via NGS with >200× mean depth | Single exon or limited amplicon Sanger, missing deep intronic variants |
| Analytical Sensitivity | 99.9% for SNVs/indels; validated on Illumina platform | ≥95% for targeted region; lower sensitivity for low-level mosaicism |
| Turnaround Time | 3–4 Weeks (expedited options available) | 6–8 Weeks |
| Clinical Coverage | Detects known and novel GHR mutations linked to classical and atypical Laron syndrome | Only pre‑defined common mutations; high miss rate for private familial variants |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I view the GHR NGS test as an essential tool for resolving the differential diagnosis of severe short stature. A definitive molecular result must be contextualized within a comprehensive paediatric endocrinology assessment, including IGF-1 generation tests and family pedigree analysis. Pre- and post-test genetic counselling is mandatory to ensure families understand the implications for growth management and reproductive planning. Rest assured, the entire workflow at DNA Labs UAE operates under strict DHA regulatory oversight.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Therapeutic Precautions
Do not discontinue prescribed IGF-1 or growth hormone therapy without consulting your endocrinologist. Abrupt cessation of endocrine therapy can lead to significant metabolic instability and adverse clinical outcomes. Always maintain your current medication regimen until explicitly advised otherwise by your treating physician.
Exclusion Criteria & Emergency Red Flags
- Blood collection is contraindicated in patients with an uncorrected bleeding diathesis or those on high-dose anticoagulant therapy without prior haematologist clearance.
- Recent (within the past 2 weeks) blood transfusion or allogeneic stem cell infusion may interfere with germline DNA interpretation; please defer testing for at least 4 weeks.
- Seek immediate medical attention (call 998 or visit the nearest ER) if you experience uncontrolled bleeding, severe pain, or signs of systemic infection at the venipuncture site following sample collection.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the GHR gene NGS test for evaluating short stature?
This test identifies pathogenic variants in the GHR gene, which confirms the diagnosis of Laron syndrome (growth hormone insensitivity). A definitive molecular diagnosis helps distinguish this condition from other forms of short stature, directly informing precise IGF-1 replacement therapy and avoiding ineffective growth hormone treatment.
2. How does the VIP home collection service guarantee sample integrity for this sensitive genetic analysis?
Our certified phlebotomists follow a standardized collection protocol using dedicated cold-chain transport containers that maintain a stable 2–8°C environment. The sample is processed in our ISO 15189 accredited laboratory within 4 hours of collection, ensuring optimal DNA yield and structural integrity for downstream NGS library preparation.
3. What are the mandatory regulatory steps before proceeding with this genetic test in the UAE?
A referral from a DHA-licensed physician is mandatory for all genetic testing. Furthermore, pre-test genetic counselling is strongly recommended to ensure informed decision-making and accurate family pedigree construction, fully complying with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to the highest standards of data protection and digital health regulation. All patient data is processed, stored, and transmitted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our clinical safety protocols and patient consent procedures are rigorously guided by Federal Decree-Law No. 4 of 2016 on Medical Liability. We operate under the direct oversight of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | GHR Gene Laron Syndrome NGS Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood or FTA Card (Peripheral Blood) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina Platform |
| ICD-10-CM Code | E34.3 |
| LOINC Code | 94233-2 |
| DHA Facility License & Laboratory Address | DHA Facility License No.: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians