Test Price
2,800 AED✅ Home Collection Available
FLNB Gene Larsen Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
Diagnostic Accuracy: Analytical sensitivity exceeding 99.9% via ISO-compliant next-generation sequencing (NGS) workflow.
Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
Clinical Guidance: Complimentary post-result teleconsultation with a Consultant Medical Genetics specialist for result interpretation.
Insurance Verification: Coverage check via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The FLNB Gene Larsen Syndrome Genetic Test is a comprehensive next-generation sequencing assay that screens for pathogenic variants in the FLNB gene, ensuring precise diagnosis of Larsen syndrome, atelosteogenesis types I and III, and spondylocarpotarsal synostosis syndrome. Full exon and splice-site coverage delivers robust clinical utility for orthopaedic genetics and multidisciplinary paediatric care.
| Feature | Our Test (NGS FLNB) | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Precision / Coverage | Full gene sequencing with >99.9% analytical sensitivity; covers all exons and splice sites | Hotspot analysis only; limited to few known mutations |
| Methodology | Next-Generation Sequencing (NGS) with advanced bioinformatics | Sanger sequencing |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks (incomplete coverage) |
| Clinical Utility | Comprehensive for Larsen syndrome, atelosteogenesis, spondylocarpotarsal synostosis | May miss novel or rare variants |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical correlation remains paramount; a negative sequencing result does not exclude all genetic causes of skeletal dysplasia, and a positive finding confirms predisposition but must be integrated with thorough physical examination and three-generation pedigree analysis. Pre- and post-test genetic counselling is essential to guide management decisions and accurately estimate recurrence risk for the family.
Medication Advisory
Do not discontinue or alter any prescribed medication without consulting your treating physician. The genetic test result may inform future therapeutic choices, but ongoing treatments must be maintained until explicitly adjusted by a qualified healthcare provider.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active bleeding disorder, recent blood transfusion within 2 weeks, inability to provide informed consent, or patient younger than 7 days without documented clinical justification.
- Emergency Red Flags: Seek immediate emergency care if the patient experiences acute joint dislocation with severe pain, difficulty breathing, stridor, or signs of spinal cord compression (new-onset limb weakness, bowel or bladder dysfunction).
Patient FAQ & Clinical Guidance
1. What conditions does the FLNB gene test detect?
This test identifies FLNB gene mutations causing Larsen syndrome, atelosteogenesis types I and III, and spondylocarpotarsal synostosis syndrome. In addition to classic Larsen syndrome—characterised by multiple joint dislocations and distinctive facial features—the assay detects variants associated with severe congenital skeletal dysplasias, enabling targeted orthopaedic and multidisciplinary care from infancy.
2. How is the sample collected, and does the test require any preparation?
A standard peripheral whole blood draw or dried blood spot (FTA card) is collected painlessly by our VIP mobile phlebotomy team. No fasting or medication discontinuation is required. A pre-test genetic counselling session is recommended to construct a detailed pedigree and can be arranged telephonically prior to sample collection. Temperature-controlled cold-chain logistics guarantee specimen integrity from your doorstep to our ISO-certified laboratory.
3. What does the test result mean, and what are the next steps?
A positive result confirms the presence of a disease-causing FLNB mutation and guides targeted orthopaedic surveillance, genetic counselling, and family planning. A negative result reduces the likelihood of FLNB-related disorders but does not rule out other genetic skeletal dysplasias; further testing such as whole exome sequencing may be considered. All results are reviewed by a Consultant Medical Genetics specialist, and a complimentary post-test teleconsultation is provided to explain implications for the patient and family.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Accreditation
This service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All testing is performed under ISO 9001:2015 certification with DHA facility license 1143. Medical liability standards adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Medical coding: ICD-10-CM Q68.8 (Larsen syndrome), Z15.89 (genetic susceptibility), Z84.89 (family history). LOINC code: 93341-5 (FLNB gene mutation analysis).
Clinical & Logistical Metadata
| Test Name | FLNB Gene Larsen Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | Q68.8, Z15.89, Z84.89 |
| LOINC Code | 93341-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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