Test Price
2,800 AED✅ Home Collection Available
FANCF Gene (Fanconi Anemia Type F) Genetic Test in UAE | DNA Labs UAE | 2800 AED
Executive Summary & Core Metrics
DNA Labs UAE offers a comprehensive diagnostic sequencing of the FANCF gene using Next-Generation Sequencing (NGS) technology, achieving 99.9% sensitivity for single nucleotide variants (SNVs), insertions/deletions (indels), and copy number variants (CNVs). This test is critical for the definitive diagnosis of Fanconi Anemia Type F, carrier frequency determination, and personalized cancer risk stratification. The laboratory operates under DHA Facility License No. 1143 and maintains ISO 9001:2015 certification. For patient convenience, a VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service is available daily from 8 AM to 11 PM.
Test Overview & Methodology
Fanconi anemia type F is a rare inherited bone marrow failure syndrome caused by biallelic pathogenic variants in the FANCF gene, which plays a crucial role in the FA/BRCA DNA damage repair pathway. Our clinical-grade NGS assay provides complete exon and flanking intronic coverage with orthogonal Sanger sequencing confirmation for all clinically significant findings, enabling precise differentiation from other inherited bone marrow failure syndromes.
| Parameter | Our Test – DNA Labs UAE | Closest Alternative |
|---|---|---|
| Methodology | NGS with 100% exon coverage & Sanger validation | Chromosomal breakage assay (DEB test) – phenotypic only |
| Time to Result | 15 – 21 Business Days | 5 – 7 Days (limited sensitivity) |
| Diagnostic Accuracy | 99.9% sensitivity for SNVs, indels & CNVs | ~70% sensitivity, cannot identify carrier status |
| Clinical Utility | Definitive genetic diagnosis, family screening, cancer risk stratification | Supports diagnosis but requires genetic confirmation |
Physician Insight & Safety Protocols
"The comprehensive analysis of the FANCF gene via NGS is indispensable for differentiating Fanconi anemia from overlapping inherited bone marrow failure syndromes. This precision directly informs critical clinical decisions, including hematopoietic stem cell transplant timing and individualized cancer risk management. Genetic counselling must always accompany the disclosure of results to ensure informed clinical utility."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics
DHA Registration ID: 9294403
Important Clinical Advisory
Therapy Modification Warning
Genetic results for the FANCF gene must not be used as the sole basis for altering prescribed haematological or oncological therapies. All treatment modifications, including adjustments to growth factors, transfusion regimens, or chemotherapeutic agents, require explicit consultation and oversight by the managing specialist.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Allogenic blood transfusion within the 2 weeks preceding sample collection.
- Exclusion: Active haemolysis or acute systemic infection that may compromise nucleic acid integrity.
- Red Flag: New or worsening pancytopenia, spontaneous mucocutaneous bleeding, or unexplained ecchymosis after sample collection – immediate haematology referral required.
- Red Flag: Development of oral leukoplakia, therapy-related myelodysplasia, or any new solid organ mass warrants urgent oncological evaluation.
Patient FAQ & Clinical Guidance
1. What is the clinical advantage of NGS over traditional chromosomal breakage testing for Fanconi Anemia?
NGS directly identifies the specific pathogenic DNA sequence variants within the FANCF gene, providing a definitive molecular diagnosis. In contrast, chromosomal breakage assays (DEB test) only measure phenotypic cellular sensitivity to DNA cross-linking agents and cannot distinguish between different FA complementation groups or identify asymptomatic carriers.
2. How should a positive FANCF result influence family planning and screening?
Identification of a pathogenic FANCF variant enables precise carrier testing for at-risk family members and informs reproductive options such as preimplantation genetic testing (PGT). We recommend a formal genetic counselling session to construct a three-generation pedigree and coordinate cascade screening for first-degree relatives.
3. What is the protocol for sample collection and ensuring sample integrity?
Acceptable specimens include 2–3 mL whole blood in EDTA, 1 µg of extracted high-quality DNA, or a dried blood spot on an FTA card. All specimens must be transported under a strict ISO-certified cold chain (2–8°C). Our VIP Mobile Phlebotomy service, available from 8 AM to 11 PM, ensures proper handling and timely delivery to the laboratory.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to the UAE's federal data protection and healthcare regulatory framework:
- Data Privacy: Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Security: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Operations governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Quality Management: ISO 9001:2015 Certification (INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | FANCF Gene Full Sequencing (Fanconi Anemia Type F) |
| Price (AED) | 2,800 |
| Turnaround Time | 15 – 21 Business Days |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA (≥1 µg), or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with Orthogonal Sanger Validation |
| ICD-10-CM Code | D61.0 |
| LOINC Code | 94383-8 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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