Test Price
2,800 AEDโ Home Collection Available
FAM126A Gene Sequencing for Hypomyelinating Leukodystrophy Type 5 in UAE | 2800 AED | DHA-Approved NGS Test
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Genetic Counselling and result interpretation included.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Turnaround Time: 3โ4 Weeks from sample receipt.
- Price: 2,800 AED (inclusive of pre-test counselling, sample collection, NGS analysis, and post-test interpretation).
Test Overview & Methodology
This definitive next-generation sequencing (NGS) test analyzes the entire coding region and splice-site junctions of the FAM126A gene to confirm hypomyelinating leukodystrophy type 5 (HLD5), a rare inherited white matter disorder. The assay achieves >99.9% analytical sensitivity and specificity for all coding variants, enabling precise molecular diagnosis, informed family planning, and prognostic counselling. DNA is extracted from a peripheral whole blood sample collected via our temperature-controlled cold-chain logistics system.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Analytical Sensitivity | >99.9% for FAM126A coding variants | Variable; may miss deep intronic or low-coverage regions |
| Methodology | Targeted NGS with 100% coverage of FAM126A coding exons | Exome-wide NGS, lower depth per gene |
| Turnaround Time | 3โ4 Weeks | 8โ12 Weeks |
| Price (AED) | 2,800 | 5,400โ7,000 |
| Clinical Utility | Direct confirmation of HLD5 for family planning, prognosis, and targeted management | Incidental findings may complicate counselling; higher cost and longer wait |
Physician Insight & Safety Protocols
From Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): โFAM126A gene sequencing is the gold-standard confirmatory test for hypomyelinating leukodystrophy type 5. A positive result must be correlated with the patientโs clinical presentation and MRI phenotype, while a negative result does not entirely exclude other leukodystrophies or related white matter disorders. Comprehensive pre- and post-test genetic counselling is essential for all patients and their families.โ
Advisory Notice โ Medication & Clinical Safety
โ Do not discontinue or alter any prescribed medication without direct guidance from your treating physician. This test is intended for diagnostic confirmation only and does not replace ongoing clinical management.
Exclusion Criteria
- Active bleeding disorder or anticoagulant therapy that precludes safe venipuncture.
- Known allergy to antiseptics or adhesives used in phlebotomy.
- Inability to provide written informed consent (required for all genetic testing under UAE law).
Emergency Red Flags โ Seek Immediate Care
- Sudden loss of consciousness or new-onset seizure.
- Severe developmental regression or acute ataxia.
- Signs of raised intracranial pressure (persistent vomiting, lethargy, bulging fontanelle).
Patient FAQ & Clinical Guidance
1. What is the FAM126A gene test, and why is it performed?
This targeted NGS test identifies pathogenic variants in the FAM126A gene to confirm a diagnosis of hypomyelinating leukodystrophy type 5 (HLD5). It enables precise molecular diagnosis, accurate prognosis, informed family planning, and tailored supportive care. The test uses DNA extracted from a simple peripheral blood sample and can differentiate HLD5 from other leukodystrophies that present with similar MRI patterns.
2. How should I prepare, and what does the 2,800 AED price include?
No special preparation is required. A certified phlebotomist collects a blood sample at your home or office via our ISO-certified cold-chain transport system available daily from 8 AM to 11 PM. The all-inclusive price of 2,800 AED covers the NGS test, pre-test genetic counselling, sample collection, and a telephonic post-test clinical interpretation session. Direct insurance billing verification is available via WhatsApp.
3. What do my results mean, and what are the next steps?
A positive result indicates a disease-causing FAM126A variant confirming HLD5; your neurologist and genetic counsellor will discuss prognosis, family cascade screening, and potential supportive therapies. A negative result with persistent clinical suspicion may prompt broader genetic panels or whole-exome sequencing. Results are delivered within 3โ4 weeks, and our genetics team is available to explain every aspect of the report.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) within DHA-licensed premises. Clinical safety and patient consent requirements adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | FAM126A Gene Sequencing (Hypomyelinating Leukodystrophy Type 5) |
| Price (AED) | 2,800 (all-inclusive) |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) โ 100% coding region coverage of FAM126A |
| ICD-10-CM Code | G93.89 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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