Test Price
2,800 AED✅ Home Collection Available
DSG1 Gene Sequencing (Erythroderma, Palmoplantar Keratoderma, Hypotrichosis, Hyper-IgE Syndrome) – UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity achieved through ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test guidance from a genetic counsellor to interpret results and recommend next steps.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic analysis uses Next-Generation Sequencing (NGS) on the Illumina platform to sequence the entire DSG1 gene. It detects pathogenic mutations responsible for a rare autosomal recessive syndrome characterized by congenital erythroderma, palmoplantar keratoderma, hypotrichosis, and significantly elevated immunoglobulin E (hyper-IgE).
| Feature | Our Test (DHA-Approved) | Closest Alternative (Whole Exome) |
|---|---|---|
| Methodology | Targeted NGS (Illumina) – 100% DSG1 coverage | Whole Exome Sequencing (WES) – may miss deep intronic variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Price | 2,800 AED | 5,000–8,000 AED |
| Clinical Sensitivity | 99.9% for DSG1 mutations | ~95% (may require reanalysis) |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I have seen how molecular clarity can empower families facing rare syndromes. This test offers precise DSG1 analysis, but results must be interpreted alongside clinical findings and family history. Genetic counselling is strongly recommended to help patients understand implications for themselves and their relatives."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License 9294403
Medication Advisory
Do not discontinue or modify any prescribed medication without consulting your physician. Inform the phlebotomist of all current medications, especially anticoagulants, to ensure safe sample collection. A buccal swab may be used if blood collection is contraindicated.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not recommended for individuals who have received a blood transfusion within the last 14 days, or who cannot provide informed consent. For minors, consent must be given by a parent or legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Exclusion: Patients on anticoagulant therapy must inform the phlebotomist; an alternative collection method (buccal swab or FTA card) may be used.
- Red Flag – Seek Emergency Care Immediately: If you experience sudden high fever, blistering, severe skin pain, or symptoms of anaphylaxis after sample collection, go to the nearest emergency department immediately. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What does the DSG1 gene test detect?
This test identifies pathogenic variants in the DSG1 gene responsible for a rare autosomal recessive syndrome that includes congenital erythroderma, palmoplantar keratoderma, hypotrichosis, and elevated immunoglobulin E levels.
2. How long do results take?
Results are typically ready within 3 to 4 weeks from the date the sample is received at our genetics laboratory in Dubai.
3. Is this test covered by insurance?
Many UAE health insurance policies cover genetic testing when medically indicated. Our team provides direct billing verification via WhatsApp at +971 54 548 8731 before sample collection.
UAE Regulatory & Data Privacy Adherence
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data is handled under strict privacy protocols.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governs secure health data transfer.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – ensures patient consent and safety in clinical procedures.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
- DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | DSG1 Gene Sequencing (Erythroderma, Palmoplantar Keratoderma, Hypotrichosis, Hyper-IgE Syndrome) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform |
| ICD-10-CM Code | Q80.9 |
| LOINC Code | 94887-6 |
| DHA Facility License & Laboratory Address | DHA License 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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